Neurosyphilis in Brazilian newborns: a health problem that could be avoided

Ribeiro, Anny Danyelly da Costa; Dan, Cristiane de Sá; Santos, Andréa da Silva; Croda, Júlio; Simionatto, Simone

doi:10.1590/s1678-9946202062082

Cited by 3 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, CSF abnormalities, including reactive VDRL or elevated WBC count or protein levels, were detected in 31.6% (18/57) of infants with CS, while none of these infants had neurological symptoms. The diagnosis of congenital neurosyphilis is difficult to establish since the majority of infants with CS do not manifest any abnormalities on neurologic examination ( 31 ). Currently, central nervous system invasion by T. pallidum is usually inferred from CSF abnormalities, such as reactive VDRL, pleocytosis, and elevated protein levels ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

The Clinical Characteristics and Serological Outcomes of Infants With Confirmed or Suspected Congenital Syphilis in Shanghai, China: A Hospital-Based Study

et al. 2022

View full text Add to dashboard Cite

BackgroundCongenital syphilis (CS) is the infection of an infant or fetus with Treponema pallidum. The aim of this study was to investigate the clinical features and outcomes of serology reversion in infants diagnosed with confirmed or suspected congenital syphilis (CS).MethodsInfants admitted to the neonatal department of Children's Hospital of Fudan University from 2013 to 2016 who met the case definition of CS or suspected CS were included in this study. Follow-up was performed in an outpatient clinic until reversion to non-reactivity of both toluidine red unheated serum test (TRUST) and Treponemal pallidum particle agglutination (TPPA). Follow-up data were collected until up to the end of 2019, when the last infant with CS reached 3 years of age.ResultsIn total, 682 infants were enrolled in this study, including 63 in the CS group and 619 in the suspected CS group. Forty-seven infants (74.6%) in the CS group had symptoms, and 57 (90.5%) had abnormal laboratory and/or long bone X-ray findings. By 6 months of age, TRUST results were negative in 53.3% of the infants with CS and in 100% of the infants with suspected CS. All the infants in the CS group returned to TRUST non-reactivity by 18 months of age. The TPPA results at 18 months of age showed that only 10.0% (3/30) of the patients in the CS group returned to non-reactivity, while a 99.6% (548/550) non-reactivity rate was observed in the suspected CS group. All the infants in the CS group returned to 19S-IgM-TPPA non-reactivity by 6 months of age.ConclusionsAlthough CS is an burdensome disease that may cause fetal and neonatal death, CS responds well to treatment when diagnosed and treated promptly, even when symptoms or lab/X-ray findings are present at birth.

show abstract

Section: Discussionmentioning

confidence: 99%

The Clinical Characteristics and Serological Outcomes of Infants With Confirmed or Suspected Congenital Syphilis in Shanghai, China: A Hospital-Based Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…A sífilis gestacional afeta cerca de 1,5 milhão de gestantes por ano em todo o mundo 4,10 . No Brasil, segundo os dados fornecidos pelo Boletim Epidemiológico da Sífilis (2020), em 2019, houve 61.127 casos de sífilis em gestantes (taxa de detecção de 20,8/1.000 nascidos vivos), 24.130 casos de sífilis congênita (taxa de incidência de 8,2/1.000 nascidos vivos) e 173 óbitos por sífilis congênita (taxa de mortalidade de 5,9/100.000 nascidos vivos) 6 .…”

Section: Introductionunclassified

“…Condições Crônicas e Infecções Sexualmente Transmissíveis (DCCI) do Ministério da Saúde (MS), estima-se que cerca de 236.603 mulheres foram diagnosticadas com sífilis gestacional no período de 2016 a 2020, sendo que, dentre esses, 106.240, provavelmente, evoluíram para sífilis congênita 11 . Dessa forma, é possível observar que quase metade das gestantes não tratadas apresentam resultados adversos, pois essa doença pode afetar o desenvolvimento do feto e neonatos, aumentando a possibilidade de aborto, parto prematuro, malformações esqueléticas, meningite e pneumonia 4,10 . Outro agravante, oriundo desta patologia, é a neurossífilis, infecção no Sistema Nervoso Central (SNC), com alterações do líquido cefalorraquidiano em recém-nascidos assintomáticos ou casos mais graves, como paralisia geral progressiva 4 .…”

Section: Introductionunclassified

Sífilis Congênita No Brasil: Panorama Atualizado Da Incidência E Fatores De Influência

Freitas

Santana

Freitas

et al. 2021

RUC

View full text Add to dashboard Cite

Objetivo: destacar fatores de risco e discutir o panorama atual da Sífilis congênita no Brasil. Métodos: trata-se de uma revisão integrativa de literatura, baseada no modelo PRISMA com busca de artigos nas bases de pesquisas biomédicas Pubmed e Science Direct, em um intervalo de publicação de 2011 a 2020, o que resultou na produção de um fluxograma, seguindo as etapas de identificação, seleção e inclusão dos dados. Resultados: foi observado um aumento significativo na incidência de casos de sífilis gestacional e congênita na última década. Além disso, foi possível o levantamento de grupos que apresentam maior propensão em transmitir a sífilis congênita; sendo as mulheres com baixa escolaridade, em vulnerabilidade socioeconômica, em uso de drogas ilícitas, durante a gravidez, autodeclaradas pretas ou pardas e a alta incidência de sexo desprotegido, as casualidades que levaram ao aumento dos casos. Considerações finais: este estudo sugere possíveisfalhas do sistema de saúde em oferecer um pré-natal adequado, diagnóstico assertivo de sífilis e outras ISTs, tratamento correto e campanhas de conscientização que alcance os grupos de maior propensão.

show abstract

Neurosyphilis: insights into its pathogenesis, susceptibility, diagnosis, treatment, and prevention

Wu,

Ye,

Wang

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

Background and aimInvasion of the central nervous system by Treponema pallidum can occur at any stage of syphilis. In the event that T. pallidum is not cleared promptly, certain individuals may experience progression to neurosyphilis, which manifests as cognitive and behavioral abnormalities, limb paralysis, and potentially fatal outcomes. Early identification or prevention of neurosyphilis is therefore crucial. The aim of this paper is to conduct a critical and narrative review of the latest information focusing exclusively to the pathogenesis and clinical management of neurosyphilis.MethodologyTo compile this review, we have conducted electronic literature searches from the PubMed database relating to neurosyphilis. Priority was given to studies published from the past 10 years (from 2013 to 2023) and other studies if they were of significant importance (from 1985 to 2012), including whole genome sequencing results, cell structure of T. pallidum, history of genotyping, and other related topics. These studies are classic or reflect a developmental process.ResultsNeurosyphilis has garnered global attention, yet susceptibility to and the pathogenesis of this condition remain under investigation. Cerebrospinal fluid examination plays an important role in the diagnosis of neurosyphilis, but lacks the gold standard. Intravenous aqueous crystalline penicillin G continues to be the recommended therapeutic approach for neurosyphilis. Considering its sustained prominence, it is imperative to develop novel public health tactics in order to manage the resurgence of neurosyphilis.ConclusionThis review gives an updated narrative description of neurosyphilis with special emphasis on its pathogenesis, susceptibility, diagnosis, treatment, and prevention.

show abstract

Neurosyphilis in Brazilian newborns: a health problem that could be avoided

Cited by 3 publications

References 18 publications

The Clinical Characteristics and Serological Outcomes of Infants With Confirmed or Suspected Congenital Syphilis in Shanghai, China: A Hospital-Based Study

The Clinical Characteristics and Serological Outcomes of Infants With Confirmed or Suspected Congenital Syphilis in Shanghai, China: A Hospital-Based Study

Sífilis Congênita No Brasil: Panorama Atualizado Da Incidência E Fatores De Influência

Neurosyphilis: insights into its pathogenesis, susceptibility, diagnosis, treatment, and prevention

Contact Info

Product

Resources

About