Susceptibility of phlebotomine sandflies (Diptera: Psychodidae) collected in the field, to alpha-cypermethrin in four municipalities endemic to leishmaniasis

Rocha, Douglas de Almeida; Andrade, Andrey José de; Moura, Luciana Reinaldo; Gontijo, Nelder F.; Pessoa, Grasielle Caldas D’Ávila; Obara, Marcos Takashi

doi:10.1590/s1678-9946202062038

Cited by 3 publications

(1 citation statement)

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“…longipalpis populations from Monte Claros, Brazil, showed resistance to deltamethrin 0.05% (63.7% mortality) and possible permethrin tolerance, as increased LT 50 (time of exposure causing 50% mortality of the tested population) permethrin (0.10%) values were recorded compared to other field populations tested (Lapinha Cave) [ 91 ]. In 2015, Rocha and colleagues [ 92 ] performed dose–response CDC bottle bioassays against alpha-cypermethrin in mixed Lutzomyia spp. populations ( L .…”

Section: Methodsmentioning

confidence: 99%

Chemical control and insecticide resistance status of sand fly vectors worldwide

et al. 2021

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Background Phlebotomine sand flies are prominent vectors of Leishmania parasites that cause leishmaniasis, which comes second to malaria in terms of parasitic causative fatalities globally. In the absence of human vaccines, sand fly chemical-based vector control is a key component of leishmaniasis control efforts. Methods and findings We performed a literature review on the current interventions, primarily, insecticide-based used for sand fly control, as well as the global insecticide resistance (IR) status of the main sand fly vector species. Indoor insecticidal interventions, such as residual spraying and treated bed nets are the most widely deployed, while several alternative control strategies are also used in certain settings and/or are under evaluation. IR has been sporadically detected in sand flies in India and other regions, using non-standardized diagnostic bioassays. Molecular studies are limited to monitoring of known pyrethroid resistance mutations (kdr), which are present at high frequencies in certain regions. Conclusions As the leishmaniasis burden remains a major problem at a global scale, evidence-based rational use of insecticidal interventions is required to meet public health demands. Standardized bioassays and molecular markers are a prerequisite for this task, albeit are lagging behind. Experiences from other disease vectors underscore the need for the implementation of appropriate IR management (IRM) programs, in the framework of integrated vector management (IVM). The implementation of alternative strategies seems context- and case-specific, with key eco-epidemiological parameters yet to be investigated. New biotechnology-based control approaches might also come into play in the near future to further reinforce sand fly/leishmaniasis control efforts.

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Section: Methodsmentioning

confidence: 99%