Human visceral leishmaniasis: epidemiological, temporal and spacial aspects in Northeast Brazil, 2003-2017

Cavalcante, Francisco Roger Aguiar; Cavalcante, Kellyn Kessiene de Sousa; Florêncio, Caroline Mary Gurgel Dias; Moreno, Jarier de Oliveira; Correia, Francisco Gustavo Silveira; Alencar, Carlos Henrique

doi:10.1590/s1678-9946202062012

Cited by 21 publications

(24 citation statements)

References 25 publications

(17 reference statements)

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“…Some regions of Maranhão compound the Legal Brazilian Amazon, which is a strategic place for agrobusiness interests and has been suffering profound anthropic modifications in the ecosystem [ 41 ]. Similarly, recent study carried out in Ceará pointed out that the highest VL incidences occur in Sobral and Cariri, where there are rapid and unplanned urbanizing, intense anthropic action and migration [ 42 ]. Thus, we hypothesize that the association between the environmental modifications and the deterioration of living conditions of population from Maranhão and Ceará states can partially explain the VL expansion.…”

Section: Discussionmentioning

confidence: 99%

Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study

et al. 2021

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Background Despite visceral leishmaniasis (VL) being epidemic in most Brazilian regions, the Northeast region is responsible for the highest morbidity and mortality outcomes within the country. Objective To analyse the spatiotemporal dynamics of VL cases to identify the temporal trends and high-risk areas for VL transmission, as well as the association of the disease with social vulnerability in Brazilian Northeast. Methods We carried out an ecological time series study employing spatial analysis techniques using all VL confirmed cases of 1,794 municipalities of Brazilian Northeast between the years 2000 to 2017. The Social Vulnerability Index (SVI) was used to represent the social vulnerability. Incidence rates were standardized and smoothed by the Local Empirical Bayesian Method. Time trends were examined through segmented linear regression. Spatiotemporal analysis consisted of uni- and bivariate Global and Local Moran indexes and space-time scan statistics. Results Incidence rate remained stable and ranged from 4.84 to 3.52 cases/100,000 inhabitants. There was higher case prevalence between males (62.71%), children and adolescents (63.27%), non-white (69.75%) and urban residents (62.58%). Increasing trends of new cases were observed among adult male subjects (≥ 40 years old) and urban residents. Importantly, VL incidence showed a direct spatial dependence. Spatial and space-time clusters were identified in sertão and meio-norte sub-regions, overlapping with high social vulnerability areas. Conclusions VL is a persistent health issue in Brazilian Northeast and associated with social vulnerability. Space-time clustering of VL cases in socially vulnerable municipalities demands intersectoral public policies of surveillance and control, with focus on reducing inequalities and improving living conditions for regional inhabitants.

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Section: Discussionmentioning

confidence: 99%

Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study

et al. 2021

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“…De acordo com a classificação do Ministério da Saúde, o município passou de área de transmissão intensa de LV (média de casos nos últimos 3 anos >4,4) para área de transmissão esporádica (média de casos nos últimos 3 anos >0 e <2,4) nos anos recentes 6 . Entretanto, após um grande declínio de 2008 a 2018, a incidência de LV em Picos tornou a aumentar em 2019, ratificando a importância da manutenção da vigilância epidemiológica e medidas de controle no município para evitar comportamento cíclico da LV como tem ocorrido em outras áreas, com surtos em intervalos periódicos 11,[21][22][23] .…”

Section: Resultsunclassified

“…A LV predominou em homens e em crianças, seguindo o padrão da doença no Brasil [20][21][22][23] . A incidência maior em homens pode ter causa comportamental, pois homens são mais envolvidos em atividades noturnas fora do domicílio, estando mais expostos ao vetor, além de causa fisiológica, pois níveis elevados de testosterona estimulam resposta imune anti-inflamatória do tipo Th2, tornando-os mais susceptíveis à Leishmania 25 .…”

Section: Resultsunclassified

Aspectos epidemiológicos e distribuição espacial da leishmaniose visceral em Picos, Piauí, Brasil

Abreu¹,

Siqueira²,

Maia³

et al. 2021

SaudColetiv (Barueri)

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Objetivo: Objetivou-se investigar o perfil epidemiológico e a distribuição espacial da leishmaniose visceral (LV) em Picos. Métodos: Dados de casos de LV de 2007 a 2019 foram obtidos de registros do Sistema de Informação de Agravos de Notificação através da Secretaria Municipal de Saúde. Resultados: Um total de 64 casos foram confirmados. A LV ocorreu em todos os anos, exceto em 2018. A taxa de incidência média foi de 6,6/100 mil habitantes e a taxa de letalidade média foi de 14,1%. A maioria dos casos ocorreu em crianças e adultos do sexo masculino, de cor parda e residentes na área urbana. Coinfecção com HIV ocorreu em 6,3% dos casos. A doença foi confirmada em 14 bairros do município. Conclusão: O estudo ratifica a importância da vigilância para LV em áreas do interior do estado, para detecção de mudanças no perfil epidemiológico da LV bem como estabelecer medidas de controle apropriadas.

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“…Ceará, 2007Ceará, -2010Ceará, , 2011Ceará, -2014Ceará, and 2015Ceará, -2018 addition to intense real estate speculation. Such factors favour anthropic action on the environment, leading to a greater VL risk for people (Cavalcante et al, 2020;Macedo et al, 2020).…”

Section: F I G U R Ementioning

confidence: 99%

Risk areas for Human Visceral Leishmaniosis 2007–2018: A temporal and spatial analysis in Ceará, Brazil

Cavalcante

Moreno

Boigny

et al. 2021

Zoonoses and Public Health

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Visceral leishmaniasis (VL) is considered as an important tropical disease because it rapidly spreads across a wide geographical area. This study aimed to analyse the temporal and spatial patterns of incidence, mortality and case fatality rates due to human VL in Ceará, Brazil, from 2007 to 2018. This is an ecological study involving time series and spatial analyses, and data were obtained from human VL notifications.Temporal trend analysis was carried out using the Joinpoint Regression Program. SaTScan 9.6 was used for conducting spatial analyses, and ArcMap 9.2 was used for building maps. There were 6,066 incident cases and 516 deaths due to human VL.

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Human visceral leishmaniasis: epidemiological, temporal and spacial aspects in Northeast Brazil, 2003-2017

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Cited by 21 publications

References 25 publications

Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study

Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study

Aspectos epidemiológicos e distribuição espacial da leishmaniose visceral em Picos, Piauí, Brasil

Risk areas for Human Visceral Leishmaniosis 2007–2018: A temporal and spatial analysis in Ceará, Brazil

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Human visceral leishmaniasis: epidemiological, temporal and spacial aspects in Northeast Brazil, 2003-2017

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Cited by 21 publications

References 25 publications

Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study

Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study

Aspectos epidemiológicos e distribuição espacial da leishmaniose visceral em Picos, Piauí­, Brasil

Risk areas for Human Visceral Leishmaniosis 2007–2018: A temporal and spatial analysis in Ceará, Brazil

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Aspectos epidemiológicos e distribuição espacial da leishmaniose visceral em Picos, Piauí, Brasil