Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection

Eyer-Silva, Walter de Araújo; Almeida, Marina Rodrigues de; Martins, Carlos José; Basílio-de-Oliveira, Rodrigo; Araújo, Luciana Ferreira de; Basílio-de-Oliveira, Carlos Alberto; Azevedo, Marcelo Costa Velho Mendes de; Pinto, Jorge Francisco da Cunha; Vasconcellos, Sidra Ezídio Gonçalves; Rodrigues-dos-Santos, Ícaro; MagdinierGomes, Harrison; Suffys, Philip Noël

doi:10.1590/s1678-9946201961071

Cited by 7 publications

(1 citation statement)

References 20 publications

(23 reference statements)

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“…These lesions appeared precisely at the sites of the previously healed primary lesions from antimycobacterial treatment. Contrary to expectations, microbiological analyses of these worsening lesions were negative, and they spontaneously remitted without initiating a novel antimycobacterial treatment cycle 15 …”

Section: Bacterial Infectionscontrasting

confidence: 90%

Skin and mucosal manifestations of immune reconstitution inflammatory syndrome in people living with HIV: a review

Górecka,

Majewski,

Szymańska

et al. 2024

Int J Dermatology

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Opportunistic infections have significantly decreased in individuals living with human immunodeficiency virus and receiving antiretroviral therapy. However, in approximately 10%–25% of patients, severe skin reactions during immune reconstruction are constantly increasing. This may manifest as either an exacerbation of a chronic disease or the development of a new disorder, referred to as immune reconstitution inflammatory syndrome. This review focuses on the current knowledge regarding the dermatological symptoms of immune reconstitution inflammatory syndrome observed in recent years. These symptoms encompass various pathogens, neoplasms, and certain autoimmune diseases. In addition to the most common skin reactions, attention is directed towards conditions not previously described in any review, such as psoriasis.

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Section: Bacterial Infectionscontrasting

confidence: 90%