Circulation of Chikungunya virus East-Central-South Africa genotype during an outbreak in 2016-17 in Piaui State, Northeast Brazil

Cardoso, Felipe Daniel; Rezende, Izabela Maurício de; Barros, E.; Sacchetto, Lívia; Garcês, Tereza Cristina de Carvalho Souza; Silva, Natalia Ingrid Oliveira; Alves, Pedro Augusto; Soares, Jefferson Oliveira; Kroon, Erna Geessien; Pereira, Anna Carolina Toledo da Cunha; Drumond, Betânia Paiva; Ferreira, Gustavo Portela

doi:10.1590/s1678-9946201961057

Cited by 12 publications

(7 citation statements)

References 33 publications

(40 reference statements)

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“…The CHIKV ECSA genotype was first reported in Brazil in 2014, in Feira de Santana, Bahia, in the Northeast region and, in the following years, spread to other states, being identified in Bahia (2014–2017) [ 9 , 48 , 49 ], Alagoas (2016) [ 46 , 50 ], Piauí (2016–2017) [ 51 ], Sergipe (2016) [ 38 ], and Maranhão (2017) [ 40 ]. It was also identified in the Southeast region, in Rio de Janeiro (2016–2018) [ 52 , 53 ] and Minas Gerais (2017) [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Chikungunya virus Detection in Aedes aegypti and Culex quinquefasciatus during an Outbreak in the Amazon Region

Cruz

Neto

Silva

et al. 2020

Viruses

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Chikungunya virus (CHIKV) was first reported in Brazil in 2014 and, after it spread countrywide, an outbreak of febrile illness with reports of arthralgia happened in the municipality of Xinguara, Pará, Brazil in 2017, indicating the virus’ circulation. Here, we aimed to investigate CHIKV in mosquito vectors collected during an active surveillance of virus isolation in cell culture by using molecular detection and viral genome sequencing. A total of 492 Aedes, Culex and Mansonia mosquitoes were collected and separated in 36 pools according to the species and sex, and 22.2% (8/36) were positive. CHIKV was indentified in pools of Ae. aegypti females (n = 5), an Ae. aegypti male (n = 1) and in Culex quinquefasciatus females (n = 2). However, as the mosquitoes’ whole bodies were macerated and used for detection, one cannot suggest the role of the latter in the viral transmission. Despite this, vector competence studies must be carried out in the different species to investigate long-term adaptations. Viral genome sequencing has characterized the East-Central-South-African (ECSA) genotype in all positive pools analyzed, corroborating previous reports for the Amazon region.

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Section: Discussionmentioning

confidence: 99%

Chikungunya virus Detection in Aedes aegypti and Culex quinquefasciatus during an Outbreak in the Amazon Region

Cruz

Neto

Silva

et al. 2020

Viruses

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“…A year later, in 2014, in Brazil, the co-circulation of the Asian and ECSA genotypes were reported in Northern and Northeastern, respectively [8,9]. Since then, the ECSA genotype has been detected in several other Brazilian states in the northeastern, southeastern, and northern regions, exerting a serious threat to public health [10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil

et al. 2020

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The Chikungunya virus infection in Brazil has raised several concerns due to the rapid dissemination of the virus and its association with several clinical complications. Nevertheless, there is limited information about the genomic epidemiology of CHIKV circulating in Brazil from surveillance studies. Thus, to better understand its dispersion dynamics in Rio de Janeiro (RJ), one of the most affected states during the 2016–2019 epidemic waves, we generated 23 near-complete genomes of CHIKV isolates from two main cities located in the metropolitan mesoregion, obtained directly from clinical samples. Our phylogenetic reconstructions suggest the 2019-CHIKV-ECSA epidemic in RJ state was characterized by the co-circulation of multiple clade (clade A and B), highlighting that two independent introduction events of CHIKV-ECSA into RJ state have occurred between 2016–2019, both mediated from the northeastern region. Interestingly, we identified that the two-clade displaying eighteen characteristic amino acids changes among structural and non-structural proteins. Our findings reinforce that genomic data can provide information about virus genetic diversity and transmission dynamics, which might assist in the arbovirus epidemics establishing of an effective surveillance framework.

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“…In the present study, variations in the structural and non-structural genes ranged up to 39, with more mutations observed in the non-structural genes. In the case of the envelope proteins, substitutions such as E1-K211E, E2-G55R, E2-H73Y, E2-V264A, E3-V42I, and E3-P59S have implications for neurovirulence during pathogenesis ( Barr and Vaidhyanathan 2019 ; Cardoso et al. 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Chikungunya virus molecular evolution in India since its re-emergence in 2005

Chaudhary¹,

Jain

Kumar³

et al. 2021

Virus Evolution

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Chikungunya virus (CHIKV), an alphavirus of the Togaviridae family, is amongst the most medically significant mosquito-borne viruses, capable of causing major epidemics of febrile disease and severe, chronic arthritis. Identifying viral mutations is crucial for understanding virus evolution and evaluating those genetic determinants that directly impact pathogenesis and transmissibility. The present study was undertaken to expand on past CHIKV evolutionary studies through robust genome-scale phylogenetic analysis to better understand CHIKV genetic diversity and evolutionary dynamics since its reintroduction into India in 2005. We sequenced the complete genomes of 50 clinical isolates collected between 2010 and 2016 from two geographic locations, Delhi and Mumbai. We then analyzed them along with 753 genomes available on the VIPR database sampled over 15 years (2005–2020) from a range of locations across the globe, and identified novel genetic variants present in samples from this study. Our analyses show evidence of frequent reintroduction of the virus into India, and that the most recent CHIKV outbreak shares a common ancestor as recently as 2006.

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Circulation of Chikungunya virus East-Central-South Africa genotype during an outbreak in 2016-17 in Piaui State, Northeast Brazil

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Cited by 12 publications

References 33 publications

Chikungunya virus Detection in Aedes aegypti and Culex quinquefasciatus during an Outbreak in the Amazon Region

Chikungunya virus Detection in Aedes aegypti and Culex quinquefasciatus during an Outbreak in the Amazon Region

Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil

Chikungunya virus molecular evolution in India since its re-emergence in 2005

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