The magnitude of syphilis: from prevalence to vertical transmission

Cerqueira, Luciane R. P.; Monteiro, Denise Leite Maia; Taquette, Stella Regina; Rodrigues, Nádia Cristina Pinheiro; Trajano, Alexandre J. B.; Souza, Flavio Monteiro de; Araújo, Bianca De Melo

doi:10.1590/s1678-9946201759078

Cited by 26 publications

(24 citation statements)

References 16 publications

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“…A study carried out by Lima and colleagues 12 showed that the absence of prenatal care raises the chance of congenital syphilis by a factor of eleven when compared to having at least one prenatal consultation 12 . Performing adequate prenatal care enables the early diagnosis and treatment of syphilis during pregnancy, thus avoiding the vertical transmission of the disease 13 . The proportion of women who were inadequately treated and untreated totalled approximately 70% in this study, although this figure is still lower than that found in the Federal District, in which a study of 100 women with syphilis during pregnancy found that only 1% had adequate treatment of the disease.…”

Section: Discussionmentioning

confidence: 99%

Prenatal quality and clinical conditions of newborns exposed to syphilis

Pastro

Farias

Garcia

et al. 2019

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Introduction: Syphilis is a sexually transmitted disease caused by Treponema pallidum, and results in considerable morbidity and mortality. Congenital syphilis can lead to miscarriage, prematurity, bone deformities, hearing loss and other important clinical changes. Objective: To analyze prenatal quality and clinical conditions of newborns exposed to syphilis in a public maternity hospital in Rio Branco-Acre. Method: This is a cross-sectional study that included 92 mothers diagnosed with syphilis during pregnancy, attended from July to December 2017. Two pregnant women had fetal death, and the final sample consisted of 90 newborns exposed to syphilis. An interview with the postpartum woman was used, analysis of the pregnant woman's card and search for information from the pregnant woman's records and newborns. It was considered confirmed case of syphilis in pregnant woman: a) All pregnant women who presented non-treponemal reagent test with any titration and reagent treponemal test performed during prenatal care; b) Pregnant woman with reagent treponemal test and nonreactive or unreacted nontreponemal test, without previous treatment record. To characterize congenital syphilis we considered: a) newborn whose mother was not diagnosed with syphilis during pregnancy and who presented a nontreponemal test reactive with any titration at the time of delivery; b) child whose mother was not diagnosed with syphilis during pregnancy and had a non-treponemal test reagent at the time of delivery; c) newborns whose mother presented a reactive treponemal test and a nonreactive non-treponemal test at the moment of delivery, without previous treatment record. Results: Most newborns were born in normal delivery (65.5%), 17.8% had acute fetal distress and 11.2% required resuscitation maneuvers. Prematurity occurred in 10% of births and 12.2% of them were small for gestational age. Complete prenatal care was performed by 29.5% of the mothers, following the recommendations of the Ministry of Health of seven visits to the Health Unit and or Health Professional. From the 90 pregnant women, 79 had a reactive treponemal test when admitted to the maternity ward. 29.3% of them performed the treatment properly. In the analysis about the treatment of the sexual partner, it was reported that 58% did not adhere to syphilis treatment. Conclusion: The prenatal quality of pregnant women with syphilis was lower than that recommended by the Brazilian Ministry of Health, although there are few cases of syphilis as the primary outcome in newborns with childbirth with mothers diagnosed with syphilis. Prenatal, newborn, syphilis in pregnancy, congenital syphilis.

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Section: Discussionmentioning

confidence: 99%

Prenatal quality and clinical conditions of newborns exposed to syphilis

Pastro

Farias

Garcia

et al. 2019

jhgd

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“…Esse fato mostra o quanto ainda há falhas sobre as formas de prevenção da IST. Estudo realizado no Rio de Janeiro mostrou que a ocorrência de gestação prévia com sífilis não eliminou o risco da doença em futuras gestações (22) .…”

Section: Discussionunclassified

Sífilis Gestacional: Repercussões Para a Puérpera

et al. 2019

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Objetivo: conhecer as repercussões do diagnóstico de Sífilis Gestacional para a puérpera.Método: pesquisa qualitativa realizada em uma unidade de pediatria de um hospital universitáriodo sul do Brasil. Participaram 15 puérperas de crianças internadas no setor com diagnóstico deSífilis Congênita. Os dados foram coletados por entrevistas semiestruturadas no primeiro semestrede 2018 e submetidos à análise de conteúdo.Resultados: obtiveram-se dados acerca do recebimento do diagnóstico, das reações frente aodiagnóstico, da influência do diagnóstico na gestação e parto e da realização do tratamento daSífilis Gestacional.Conclusão: verificou-se desinformação das puérperas quanto à infecção da sífilis, principalmentesobre cuidados para evitar a transmissão e a reinfecção. Destaca-se o papel educativo do enfermeirojunto a essas mulheres na busca pela diminuição das (re)infecções por Sífilis.

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“…Syphilis, an important cause of both stillbirth and neonatal death in some regions, will be documented for this study . Since syphilis is virtually always transmitted transplacentally from the mother to the fetus during pregnancy and is associated with a maternal antibody response [ 16 , 17 ], all cases of syphilis should be identifiable by antibodies in maternal blood or alternately, cord or neonatal blood. For all stillbirths and neonatal deaths, we will aim to test maternal serum samples for syphilis.…”

Section: Methods and Designmentioning

confidence: 99%

The project to understand and research preterm pregnancy outcomes and stillbirths in South Asia (PURPOSe): a protocol of a prospective, cohort study of causes of mortality among preterm births and stillbirths

et al. 2018

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BackgroundIn South Asia, where most stillbirths and neonatal deaths occur, much remains unknown about the causes of these deaths. About one-third of neonatal deaths are attributed to prematurity, yet the specific conditions which cause these deaths are often unclear as is the etiology of stillbirths. In low-resource settings, most women are not routinely tested for infections and autopsy is rare.MethodsThis prospective, cohort study will be conducted in hospitals in Davengere, India and Karachi, Pakistan. All women who deliver either a stillbirth or a preterm birth at one of the hospitals will be eligible for enrollment. With consent, the participant and, when applicable, her offspring, will be followed to 28-days post-delivery. A series of research tests will be conducted to determine infection and presence of other conditions which may contribute to the death. In addition, all routine clinical investigations will be documented. For both stillbirths and preterm neonates who die ≤ 28 days, with consent, a standard autopsy as well as minimally invasive tissue sampling will be conducted. Finally, an expert panel will review all available data for stillbirths and neonatal deaths to determine the primary and contributing causes of death using pre-specified guidance.ConclusionThis will be among the first studies to prospectively obtain detailed information on causes of stillbirth and preterm neonatal death in low-resource settings in Asia. Determining the primary causes of death will be important to inform strategies most likely to reduce the high mortality rates in South Asia.Trial registrationClinicaltrials.gov (NCT03438110) Clinical Trial Registry of India (CTRI/2018/03/012281).

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The magnitude of syphilis: from prevalence to vertical transmission

Cited by 26 publications

References 16 publications

Prenatal quality and clinical conditions of newborns exposed to syphilis

Prenatal quality and clinical conditions of newborns exposed to syphilis

Sífilis Gestacional: Repercussões Para a Puérpera

The project to understand and research preterm pregnancy outcomes and stillbirths in South Asia (PURPOSe): a protocol of a prospective, cohort study of causes of mortality among preterm births and stillbirths

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