Nursing infant with acquired toxoplasmosis in the first months of life – a case report

Rezende, Hanstter Hallison Alves; Storchilo, Heloísa Ribeiro; Lima, Jaqueline Ataíde Silva; Júnior, Antônio Roberto Gomes; Gomes, Taynara Cristina; Souza, Jéssica Yonara de; Avelino, Mariza Martins; Amaral, Waldemar Naves do; Vinaud, Marina Clare; Castro, Ana Maria de

doi:10.1590/s1678-9946201759063

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Torgerson and Mastroiacovo [63] estimated per 1000 live births the incidence of congenital cases accounting for 2-2.4 to 13-15 of all Disability-Adjusted Life Years (DALYs) for the African continent, despite several African countries have not reported cases of congenital toxoplasmosis or seroprevalence data. Infants can also acquire primary Toxoplasma infection after birth and develop severe disease [3,35,64].…”

Section: Toxoplasmosis In Neonates and Infantsmentioning

confidence: 99%

Human toxoplasmosis in Mozambique: gaps in knowledge and research opportunities

2020

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Toxoplasmosis is a parasitic zoonotic disease caused by Toxoplasma gondii that afflicts humans worldwide and wild and domestic warm-blooded animals. In immunocompetent individuals, the acute phase of infection presents transient low or mild symptoms that remain unnoticed. In immunocompromised patients, T. gondii is a life-threatening opportunistic infection, which can result from the reactivation of latent infection or primary infection. Moreover, congenital toxoplasmosis, which results from the transplacental passage of tachyzoites into the fetus during a pregnant primary infection, can lead to miscarriage, stillbirth, or ocular and neurologic disease, and neurocognitive deficits in the newborns. Thus, the present review aims to address the current knowledge of T. gondii infection and toxoplasmosis in Africa and especially in Mozambique, stressing the importance of identifying risk factors and promote awareness among the health care providers and population, assessing the gaps in knowledge and define research priorities. In Mozambique, and in general in southern African countries, clinical disease and epidemiological data have not yet been entirely addressed in addition to the implications of T. gondii infection in immunocompetent individuals, in pregnant women, and its relation with neuropsychiatric disorders. The main gaps in knowledge in Mozambique include lack of awareness of the disease, lack of diagnostic methods in health facilities, lack of genetic data, and lack of control strategies.

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Section: Toxoplasmosis In Neonates and Infantsmentioning

confidence: 99%

Human toxoplasmosis in Mozambique: gaps in knowledge and research opportunities

2020

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Identification of Biomarkers for Diagnosis and Prognosis of Congenital and Acute Toxoplasmosis

Storchilo

Teixeira

Moreira

et al. 2020

The Journal of Infectious Diseases

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Background The diagnosis of congenital toxoplasmosis can be inconclusive in many cases. Despite the several serological tests developed, the literature on biomarkers that can assist in the diagnosis of congenital an acute toxoplasmosis is limited. The objective of this study was analyze the immunoreactive profile of T. gondii protein bands with the potential to be biomarkers for diagnosis and prognosis of congenital and acute toxoplasmosis. Methods Peripheral blood samples from women of childbearing age and/or pregnant women diagnosed with acquired toxoplasmosis as well as from congenitally infected children were selected and submitted to Immunoblotting for analysis of the immunoreactive bands profile by IgG antibodies. Results When comparing the immunoreactive bands profile for antibodies present in samples from different groups and subgroups, the 150, 18.5 and 16.96 kDa bands were more immunoreactive by the antibodies present in serum samples from the acquired infection group. The 343, 189, 150, 75 and 42 kDa bands showed more chance to be detected by the symptomatic congenital infection subgroup, while the 61, 50 and 16.96 kDa bands were significantly immunoreactive by the acute infection subgroup. Conclusions The identification of these potential biomarkers can assist in an early diagnosis and treatment of congenital toxoplasmosis.

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Nursing infant with acquired toxoplasmosis in the first months of life – a case report

Cited by 2 publications

References 12 publications

Human toxoplasmosis in Mozambique: gaps in knowledge and research opportunities

Human toxoplasmosis in Mozambique: gaps in knowledge and research opportunities

Identification of Biomarkers for Diagnosis and Prognosis of Congenital and Acute Toxoplasmosis

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