Ciprofloxacin Resistance Pattern Among Bacteria Isolated From Patients With Community-Acquired Urinary Tract Infection

Abstract

SUMMARYObjective: To identify the main bacterial species associated with community-acquired urinary tract infection (UTI) and to assess the pattern of ciprofloxacin susceptibility among bacteria isolated from urine cultures. Methods: We conducted a retrospective study in all the patients with community-acquired UTI seen in Santa Helena Laboratory, Camaçari, Bahia, Brazil during five years (2010-2014). All individuals who had a positive urine culture result were included in this study. Results: A total of 1,641 individuals met the inclusion criteria. Despite the fact that participants were female, we observed a higher rate of resistance to ciprofloxacin in males. The most frequent pathogens identified in urine samples were Escherichia coli, Klebsiella pneumoniae and Staphylococcus saprophyticus. Antimicrobial resistance has been observed mainly for ampicillin, sulfamethoxazole + trimethoprim and ciprofloxacin. Moreover, E. coli has shown the highest rate of ciprofloxacin resistance, reaching 36% of ciprofloxacin resistant strains in 2014. Conclusion: The rate of bacterial resistance to ciprofloxacin observed in the studied population is much higher than expected, prompting the need for rational use of this antibiotic, especially in infections caused by E. coli. Prevention of bacterial resistance can be performed through control measures to limit the spread of resistant microorganisms and a rational use of antimicrobial policy.

Microbiology and Drug Resistance of Pathogens in Patients Hospitalized at the Nephrology Department in the South of Poland

“…Despite the fact that these values may vary among reports, the resistance rate of E. coli to cotrimoxazole in Europe tends to be above 20%, having also been reported higher than 30% (Guneysel et al 2009;Schito et al 2009). E. coli susceptibility to fluoroquinolones in the current study ranged from 60.3% (norfloxacin) to 70.4% (ciprofloxacin) which was similar to the rates observed in Brazil and Korea (Reis et al 2016;Park et al 2017). Another study reported that E. coli was least sensitive to cephalosporins (7.0-34.0%) and fluoroquinolones (26.0-28.0%); however, a study was conducted on a population from low socioeconomic strata (Kidwai et al 2017).…”

Quinolone Resistant Escherichia Coli Isolated From Chicken Meat in Bosnia and Herzegovina.

“…In EU during 2016, quinolone resistance was the most common trait and occurrence was overall very high in indicator E. coli from broilers and their meat at 59.8% and 64.0% for nalidixic acid and ciprofloxacin, respectively and rate of resistance to ampicillin was also very high (58.0%) in the EU member states (EFSA & ECDC, 2018). We can agree with the opinion of Reis and Santos (Reis et al, 2016) that prophylactic use of quinolones has a significant role in the increasing emergence of bacteria resistant to these antimicrobials. Molecular-epidemiological studies [Johnson et al, 2006;Thorsteinsdottir et al, 2010), showed that human and chicken fluoroquinolone-resistant E. coli isolates were closely related, demonstrating that poultry and their food products can be a source of resistant in humans.…”

Actinomycetes of rhizosphere soil producing antibacterial compounds against Urinary Tract Infection bacteria

“…It showed that they had ciprofloxacin resistance. In addition, Reis et al (2016) also reported that K. pneumoniae from UTI's patient showed resistant to ciprofloxacin and many other antibiotics.…”