“…In case of moderate and severe morphological signs of chronic viral hepatitis (CVH), there are relatively higher plasma and tissue concentrations of ICAM-1 and VCAM-1 [1,5,20], which were in positive correlation with the histological activity index [1,3,5,6]. A progression of hepatic fibrosis against the HCV infection was associated with a significant increase in ICAM-1 and VCAM-1 blood concentrations and direct relationship of the mediators' profiles with the hepatitis stage [2,5,6]. There is also an opposite viewpoint available, which claims no connection between the VCAM-1 level and the severity of inflammation [3,9] and fibrosis in patients with CVH [9].…”