Bioactivities of extracts from the marine sponge Halichondria panicea

Abstract

ABSTRACT:In the present study, we screened the biological activity of extracts from the marine sponge Halichondria panicea collected in the Arabian Sea. Crude toxin was obtained by methanol, chloroform-methanol (2:1) and aqueous extraction. Subsequently, the protein concentration of each crude extract was determined. The impact of both sponge methanolic and aqueous extracts was found to increase activities of Na + -K + ATP-ase and Mg ++ ATP-ase. In the case of chloroform-methanol extract, higher concentrations increased acetylcholine esterase (AchE) activity. The methanolic and chloroform-methanol extracts exhibited hemolytic activity on chicken and human erythrocytes, whereas the aqueous extract failed to do so. Methanol and aqueous extracts produced an immunostimulating effect and all extracts revealed angiogenic activity. The aqueous extract yielded nine bands by SDS-PAGE on 12% gel.

A review of bioactive compounds from marine organisms with special mention on the potential of marine sponges in pharmacological applications

“…In one of the studies by Purushottama et al (2009) three crude extracts of Halichondria panicea had shown immunostimulative effects at lower concentrations. However, at higher concentrations, they exhibited immunosuppressive effects.…”

Cytostatic activity in the hydrophilic fraction of the crude extract from the White Sea sponge Halichondria panicea

“…Halichondria panicea (Pallas, 1766), commonly known as the breadcrumb sponge, is a widespread species in the coastal waters of the North Atlantic, Mediterranean Sea and North Pacific (Erpenbeck et al, 2004) and is also known from the Indian Ocean (Purushottama et al, 2009). The substances exuded into seawater by H. panicea and the extracts obtained from this sponge were shown to have high biological activity.…”

“…The substances exuded into seawater by H. panicea and the extracts obtained from this sponge were shown to have high biological activity. The excretory-secretory products (ESPs) of H. panicea exhibit a larvicidal effect (Dyrynda, 1983) and the extracts from this sponge are toxic for human and chicken erythrocytes (Purushottama et al, 2009) and for cell cultures of mouse lymphoma (Althoff, 1998). The extracts from H. panicea also have antimicrobial effects (Thompson et al, 1985) and the proteins isolated from these extracts were shown to act as neuromodulators (Purushottama et al, 2009).…”

“…The excretory-secretory products (ESPs) of H. panicea exhibit a larvicidal effect (Dyrynda, 1983) and the extracts from this sponge are toxic for human and chicken erythrocytes (Purushottama et al, 2009) and for cell cultures of mouse lymphoma (Althoff, 1998). The extracts from H. panicea also have antimicrobial effects (Thompson et al, 1985) and the proteins isolated from these extracts were shown to act as neuromodulators (Purushottama et al, 2009). Some products of the Streptomyces strain HB202, which were isolated from the sponge H. panicea from the Baltic Sea, exhibit antibacterial activity against several pathogenic bacteria and cytotoxic activity against eight human cancer cell lines.…”

Türkiye’deki Dictyonella incisa’nın In vitro Biyoaktivitesinin Değerlendirilmesi

“…Therefore, sponges have shown widely diverse activities like anti-HIV, antibacterial, cytotoxicity, anti-fouling properties [3][4][5] . Sponges appear to be one of the richest phylum in toxicogenic species; there are approximately 15.000 sponge species which 150 of them are living in freshwaters [6] . In search of novel pharmaceutically active substances from sponges, we have engaged in bioactivity screening of sponges.…”