Domestic feline cutaneous leishmaniasis in the municipality of Ribas do Rio Pardo, Mato Grosso do Sul state, Brazil: a case report

Souza, Alda Izabel de; Nunes, Vânia Lúcia Brandão; Borralho, V. M.; Ishikawa, Edna Aoba Yassui

doi:10.1590/s1678-91992009000200017

Cited by 18 publications

(29 citation statements)

References 14 publications

(11 reference statements)

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“…However, in the Brazilian state of Bahia, it has previously been associated with human visceral leishmaniasis [ 10 ]. Although this parasite is predominantly associated with human and animal infection in rural environments [ 11 , 12 ], it has been found in dogs in Araçatuba municipality in São Paulo state and in domestic cats in urban environments in the municipalities of Campo Grande and Ribas do Rio Pardo in Mato Grosso do Sul state [ 13 – 15 ].…”

Section: Resultsmentioning

confidence: 99%

Natural infection of phlebotomines (Diptera: Psychodidae) by Leishmania (Leishmania) amazonensis in an area of ecotourism in Central-Western Brazil

Brilhante

Nunes

Kohatsu

et al. 2015

J Venom Anim Toxins Incl Trop Dis

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BackgroundBonito municipality, known as an area of ecoturism, in Mato Grosso do Sul state, Brazil, is also a focus of visceral and cutaneous leishmaniases, with cases registered in both human and canine populations. This study sought to investigate natural infection by flagellate forms of Leishmania in phlebotomines of the urban area of Bonito.FindingsSand flies were collected fortnightly from October 2005 to July 2006 with modified automatic light traps installed in peridomiciles and animal shelters in the center and on the outskirts of the city. The females were dissected and their guts observed under an optical microscope. A total of 1977 specimens were captured, Lutzomyia longipalpis (88.4 %) and Bichromomyia flaviscutelata (3.0 %) being the most frequent species. Bi. flaviscutellata was found infected by flagellates that were identified as Leishmania (Leishmania) amazonensis by indirect immunofluorescence reaction, employing monoclonal antibodies and the biotin-avidin system. This is the first report of natural infection by L. amazonensis in Bi. flaviscutellata in a Brazilian urban area.ConclusionsAs Bi. flaviscutellata is only slightly attracted by humans, the transmission of L. amazonensis in the study area may have a zoonotic character; however, the sympatric occurrence of this parasite and Lu. longipalpis should be taken into consideration by the local health authorities since this sand fly has already been found with L. amazonensis DNA in a focus of canine visceral leishmaniasis in Bonito municipality.

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Section: Resultsmentioning

confidence: 99%

Natural infection of phlebotomines (Diptera: Psychodidae) by Leishmania (Leishmania) amazonensis in an area of ecotourism in Central-Western Brazil

Brilhante

Nunes

Kohatsu

et al. 2015

J Venom Anim Toxins Incl Trop Dis

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“…Das amostras isoladas em cães soropositivos para LTA neste estado, todas foram L. braziliensis (THOMAZ-SOCCOL et al, 2009), sendo este o primeiro relato de L. amazonensis em cão no estado do Paraná. Outros dois cães em Araçatuba, no estado de São Paulo (TOLEZANO et al, 2007) e dois gatos no estado do Mato Grosso do Sul (DE SOUZA et al, 2005a;SOUZA et al, 2009) também foram infectados pelo mesmo agente.…”

Section: Discussionunclassified

Leishmania amazonensis em cão com quadro clínico de leishmaniose visceral no Estado do Paraná, Brasil – relato de caso

et al. 2012

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ResumoAs leishmanioses são antropozoonoses que envolvem diversas espécies de Leishmania e hospedeiros, tendo apresentações clínicas variáveis e consideradas de grande importância para a saúde pública. Este artigo descreve um caso de leishmaniose canina causada por Leishmania amazonensis, proveniente da cidade de Cambé, Paraná -Brasil. Este estado é considerado endêmico para a leishmaniose tegumentar americana (LTA) em humanos, porém este é o primeiro relato em cão na região, provocado pela L. amazonensis. A caracterização taxonômica da Leishmania foi realizada através da técnica multilocus enzyme electrophoresis (MLEE). Os sinais clínicos foram similares aos observados na leishmaniose visceral como poliartrite e emagrecimento progressivo. Conclui-se que a poliartrite quando relacionada à leishmaniose não pode ser considerada um sinal clínico associado somente a L. chagasi, tendo em vista que a L. amazonensis também tem esta como uma das suas formas de apresentação. A LTA torna-se um diagnóstico diferencial de poliartrite em cães. Palavras-chave: Canis familiaris, leishmaniose visceral, poliartrite AbstractLeishmaniasis are antropozoonoses involving various species of Leishmania and hosts, with variable clinical presentations and considered of great importance to public health. This article describes a case of canine leishmaniasis caused by Leishmania amazonensis, from the town of Cambé, Paraná state, Brazil. This state is considered endemic for American cutaneous leishmaniasis (ACL) in humans, but this is the first report in a dog in the region, caused by L. amazonensis. The taxonomic characterization of Leishmania was performed by multilocus enzyme electrophoresis technique (MLEE). Clinical signs were similar to those observed in visceral leishmaniasis as polyarthritis and progressive weight loss. It is concluded that the related polyarthritis when related to leishmaniasis, cannot be considered a clinical sign associated only with L. chagasi in view of the L. amazonensis also has this as one of its presentations. The LTA becomes a differential diagnosis of polyarthritis in dogs.

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“…Leishmanioses are caused by protozoan parasites of the genus Leishmania and they are endemic in at least 88 countries. More than 20 Leishmania species can infect dogs and/or humans and some of them are also infective to cats (Bonfante-Garrido et al, 1996;Craig et al, 1986;da Silva et al, 2008;Hatam et al, 2010;Pennisi et al, 2013;Poli et al, 2002;Schubach et al, 2004;Simões-Mattos et al, 2004;Souza et al, 2009;Trainor et al, 2010). Although dogs are considered the main domestic and peridomestic reservoir of zoonotic leishmaniosis caused by L. infantum (synonym: L. chagasi) (Baneth et al, 2008), cats may also be implicated in the transmission cycle of the parasite, as additional primary or as secondary reservoirs, or they may be accidental hosts (Maia and Campino, 2011;Mancianti, 2004;Maroli et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of indirect immunofluorescence antibody test and enzyme-linked immunosorbent assay for the diagnosis of infection by Leishmania infantum in clinically normal and sick cats

Chatzis

Leontides

Athanasiou

et al. 2014

Experimental Parasitology

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Cats that live in areas where canine and human leishmaniosis due to Leishmania infantum is endemic may become infected and may develop anti-Leishmania antibodies. In this study 50 clinically normal and 50 cats with cutaneous and/or systemic signs that lived in an endemic area and had been previously examined for infection by L. infantum using PCR in four different tissues were serologically tested for the presence of anti-Leishmania IgG (IFAT and ELISA) and IgM (IFAT). The aim was to compare the results of IFAT, ELISA and PCR and to investigate the possible associations between seropositivity to Leishmania spp and signalment, living conditions, season of sampling, health status of the cats, and seropositivity to other infectious agents. Low concentrations of anti-Leishmania IgG were detected by IFAT in 10% of the cats and by ELISA in 1%, whereas anti-Leishmania IgM were detected by IFAT in 1%. There was disagreement between the results of IFAT and ELISA for anti-Leishmania IgG (P = 0.039) and between all serological tests and PCR (P < 0.001). The diagnostic sensitivity of all serological tests, using PCR as the gold standard, was very low, but ELISA and IFAT for anti-Leishmania IgM had 100% specificity. The diagnostic sensitivity of all serological tests could not be improved by changing the cut-off values. Seropositivity for Leishmania spp was not associated with signalment, living conditions, season of sampling and health status of the cats or with seropositivity to feline leukemia virus, feline immunodeficiency virus, feline coronavirus, Toxoplasma gondii and Bartonella henselae. In conclusion, because of their low sensitivity and very high specificity two of the evaluated serological tests (ELISA for anti-Leishmania IgG and IFAT for anti-Leishmania IgM) may be useless as population screening tests but valuable for diagnosing feline infection by L. infantum.

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Domestic feline cutaneous leishmaniasis in the municipality of Ribas do Rio Pardo, Mato Grosso do Sul state, Brazil: a case report

Cited by 18 publications

References 14 publications

Natural infection of phlebotomines (Diptera: Psychodidae) by Leishmania (Leishmania) amazonensis in an area of ecotourism in Central-Western Brazil

Natural infection of phlebotomines (Diptera: Psychodidae) by Leishmania (Leishmania) amazonensis in an area of ecotourism in Central-Western Brazil

Leishmania amazonensis em cão com quadro clínico de leishmaniose visceral no Estado do Paraná, Brasil – relato de caso

Evaluation of indirect immunofluorescence antibody test and enzyme-linked immunosorbent assay for the diagnosis of infection by Leishmania infantum in clinically normal and sick cats

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