Interaction between infection, nutrition and immunity in tropical medicine

Pereira, Paulo Câmara Marques

doi:10.1590/s1678-91992003000200003

Cited by 15 publications

(23 citation statements)

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“…These findings corroborate previous studies that describe this distribution in burn victims (9)(10)(11)(12)(13)(14). An important factor that indirectly affects life conditions of the studied population, which can be related to nutritional behavior, is the low level of formal education (Table 2).…”

Section: Introductionsupporting

confidence: 91%

“…Burns provoked by alcohol are more profound than those caused by scalding, since the time of exposure to heat in burns by flammable liquid is longer (8,9). Nutritional status has been reported, in various studies, as an important factor in recovery of burn patients by reducing complications and rates of morbidity and mortality, which are generally elevated in these patients (9)(10)(11)(12)(13)(14). The mean height of patients was 1.67 m, while average weight was 73.86 kg and BMI was 25.81 kg/m 2 .…”

Section: Introductionmentioning

confidence: 99%

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Nutritional, immunological and microbiological profiles of burn patients

Barbosa¹,

Calvi²,

Pereira³

2009

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:A burn is a lesion on an organic tissue resultant from direct or indirect action of heat on the organism. The present study aimed to evaluate the nutritional, immunological and microbiological status of burn patients at the Bauru State Hospital, São Paulo state, Brazil, in 2007. Eight patients, aged more than 18 years and injured up to 24 hours, were evaluated at the moment of hospitalization and seven days later. All victims were males with a mean age of 38 years. On average, 17.5% of their body surfaces were burned and 50% of the patients were eutrophic. There were significant alterations in levels of erythrocytes, hemoglobin, hematocrit, total protein and albumin due to increased endothelial permeability, direct destruction of proteins in the heat-affected area and blood loss from lesions or debridement. At a second moment, cytokines IL-6 and TNF-α had augmented significantly, with IL-6 presenting elevated levels in relation to controls at the first moment. Microbiological analysis showed that 100% of the samples collected at hospital admission were negative and after one week Staphylococcus aureus was found in all cultures. Therefore, a burn patient may be considered immunosuppressed and these results indicate significant nutritional, immunological and microbiological alterations that can interfere in his recovery.

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Section: Introductionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Nutritional, immunological and microbiological profiles of burn patients

Barbosa¹,

Calvi²,

Pereira³

2009

J. Venom. Anim. Toxins incl. Trop. Dis

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“…The infectious process is usually followed by hypercatabolism, which is aggravated by anorexia, resulting in the loss and the consequent depletion of the body's nutrient reserves, thereby causing great changes in the metabolism of the host 21 . Some studies have reported differences in body mass index (BMI), glucose, triglycerides and lipoproteins in patients with active VL [22][23][24] .…”

Section: Methodsmentioning

confidence: 99%

Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs

Gatto

Abreu

Tasca

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(6):735-740, Nov-Dec, 2013http://dx.doi.org/10.1590/0037-8682-0198-2013 ABSTRACT Introduction: Visceral leishmaniasis (VL) is caused by the intracellular protozoan Leishmania donovani complex. VL may be asymptomatic or progressive and is characterized by fever, anemia, weight loss and the enlargement of the spleen and liver. The nutritional status of the patients with VL is a major determinant of the progression, severity and mortality of the disease, as it affects the clinical progression of the disease. Changes in lipoproteins and plasma proteins may have major impacts in the host during infection. Thus, our goal was evaluate the serum total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, glucose, albumin, globulin and total protein levels, as well as the body composition, of VL patients before and after treatment. Methods: Nutritional evaluation was performed using the bioelectrical impedance analysis (BIA) to assess body composition. Biochemical data on the serum total cholesterol, HDL, LDL, triglycerides, glucose, albumin, globulin and total protein were collected from the medical charts of the patients. Results: BIA indicated that both pre-treatment and post-treatment patients exhibited decreased phase angles compared to the controls, which is indicative of disease. Prior to treatment, the patients exhibited lower levels of total body water compared to the controls. Regarding the biochemical evaluation, patients with active VL exhibited lower levels of total cholesterol, HDL, LDL and albumin and higher triglyceride levels compared to patients after treatment and the controls. Treatment increased the levels of albumin and lipoproteins and decreased the triglyceride levels. Conclusions: Our results suggest that patients with active VL present biochemical and nutritional changes that are reversed by treatment. INTRODUCTION

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“…Maintenance of the nutritional state is highly important to strengthen the host and supply the elements for its defense and a better quality of life. In this sense, the patient's approach must always involve the 3 following areas simultaneously: early nutritional support, specific treatment of infection, and restoration of the immune system (13).…”

Section: Resultsmentioning

confidence: 99%

“…Host nutritional status has an important role in the susceptibility to viral infections, bacteria, and parasites. Infection accelerates the appearance of signs and symptoms of nutrition deficiencies in the undernourished individuals and can exacerbate the evolution of the infection process; they both interact synergistically and are a public health problem, mainly in areas of poor basic sanitation; poverty and ignorance also influence eating habits (13). Infections can lead to loss of appetite, decreased nutrient utilization, and efficiency of food, and increased energy requirements (14).…”

Section: Introductionmentioning

confidence: 99%

Household Food Insecurity and Its Association with Self-reported Infectious and Parasitic Diseases Among Household Mothers in Southeast of Iran

et al. 2017

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Background: Nowadays, more than 1 billion people suffer from food insecurity worldwide. Food insecurity is recognized as an important determinant of health, and both food insecurity and diseases are public health concerns. This study aimed at determining the association between food insecurity and self-reported history of infectious and parasitic diseases among household mothers in Zahedan, southeast of Iran. Methods: This cross-sectional study was conducted on 2160 households in Zahedan. Food insecurity of the households was assessed through USDA 18-item questionnaire. Demographic data and questions about history of infectious and parasitic diseases in mothers were collected through interviewing the mothers. The data were analyzed using chi-square test and logistic regression model. Results: Of the household mothers, 58.8% experienced food insecurity, 11.5% reported history of infectious diseases, and 1.1% experienced parasitic diseases in the last 3 months. After adjusting for the selected variables, a positive association was detected between food insecurity and history of infectious (OR, 2.29; 95% CI, 1.66 -3.18) and parasitic diseases (OR, 3.86; 95% CI, 1.07 -13.93) in mothers. Conclusions: Food security seems a controllable environmental factor that may cause some positive results in the fight against diseases. On the other hand, preventing and controlling infectious and parasitic diseases may in turn result in reduction of food insecurity.

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Interaction between infection, nutrition and immunity in tropical medicine

Cited by 15 publications

References 0 publications

Nutritional, immunological and microbiological profiles of burn patients

Nutritional, immunological and microbiological profiles of burn patients

Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs

Household Food Insecurity and Its Association with Self-reported Infectious and Parasitic Diseases Among Household Mothers in Southeast of Iran

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