Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease

Souza, João Antônio Chaves de; Rossa, Carlos; Garlet, Gustavo; Nogueira, Andressa Vilas Boas; Cirelli, Joni Augusto

doi:10.1590/s1678-77572012000200002

Cited by 78 publications

(56 citation statements)

References 86 publications

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“…Using histometric, immunohistochemical and enzymatic methods, the authors demonstrate that the sumac extract, administered orogastrically, inhibits periodontitis development via the regulation of oxidative status and RANKL/OPG system, opening the opportunity to possible clinical application to manage periodontitis. Also, in line with previous reports previously published in the JAOS 2 , 3 , this study reinforces the central role of RANKL/OPG system in the pathogenesis of bacterially induced inflammatory osteolytic lesions, as well supports the validity of modulating host responses strategies to arrest periodontitis 9 .…”

supporting

confidence: 92%

Bone biology & pathology moves on: from bone resorption to formation, the rise of new therapeutic opportunities and experimental tools

Garlet¹

2015

J. Appl. Oral Sci.

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supporting

confidence: 92%

Bone biology & pathology moves on: from bone resorption to formation, the rise of new therapeutic opportunities and experimental tools

Garlet¹

2015

J. Appl. Oral Sci.

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“…The conventional treatment for periodontitis relies on the mechanical removal of bacterial plaque from the periodontal pockets by scaling and root planing . Recently, a new treatment strategy based on modulating the inflammatory response to periodontal disease has been advocated . Natural plants have abundant antiinflammatory materials, many of which are pharmacologically safe .…”

Section: Introductionmentioning

confidence: 99%

“…11 Recently, a new treatment strategy based on modulating the inflammatory response to periodontal disease has been advocated. 12 Natural plants have abundant antiinflammatory materials, many of which are pharmacologically safe. 13 Therefore, plant polyphenols have been proposed as promising compounds for adjunctive periodontal therapy.…”

Section: Introductionmentioning

confidence: 99%

Effects of theaflavins on tissue inflammation and bone resorption on experimental periodontitis in rats

Kuraji

Taya

et al. 2018

J of Periodontal Research

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Background and ObjectiveTheaflavins (TFs), the major polyphenol in black tea, have the ability to reduce inflammation and bone resorption. The aim of this study was to evaluate the effects of TFs on experimental periodontitis in rats.Material and MethodsThirty rats were divided into five groups: Control (glycerol application without ligation), Ligature (glycerol application with ligation), TF1 (1 mg/mL TF application with ligation), TF10 (10 mg/mL TF application with ligation), and TF100 (100 mg/mL TF application with ligation). To induce experimental periodontitis, ligatures were placed around maxillary first molars bilaterally. After ligature placement, 100 μL glycerol or TFs were topically applied to the rats daily, and rats were euthanized 7 days after ligature placement. Micro‐computed tomography was used to measure bone resorption in the left side of the maxilla, and quantitative polymerase chain reaction was used to measure the expression of interleukin (IL)‐6, growth‐regulated gene product/cytokine‐induced neutrophil chemoattractant (Gro/Cinc‐1, rat equivalent of IL‐8), matrix metalloproteinase‐9 (Mmp‐9), receptor activator of nuclear factor‐kappa Β ligand (Rankl), osteoprotegerin (Opg), and the Rankl/Opg ratio in gingival tissue. With tissue from the right side of the maxilla, hematoxylin and eosin staining was used for histological analysis, immunohistochemical staining for leukocyte common antigen (CD45) was used to assess inflammation, and tartrate‐resistant acid phosphatase (TRAP) staining was used to observe the number of osteoclasts.ResultsThe TF10 and TF100 groups, but not the TF1 group, had significant inhibition of alveolar bone loss, reduction in inflammatory cell infiltration in the periodontium, and significantly reduced numbers of CD45‐positive cells and TRAP‐positive osteoclasts compared with the Ligature group. Correspondingly, the TF10 and TF100 groups had significantly downregulated gene expression of IL‐6, Gro/Cinc‐1(IL‐8), Mmp‐9, and Rankl, but not of Opg. Consequently, Rankl/Opg expression was significantly increased in the Ligation group but was attenuated in the TF10 and TF100 groups.ConclusionThe results of this study suggest that topical application of TFs may reduce inflammation and bone resorption in experimental periodontitis. Therefore, TFs have therapeutic potential in the treatment of periodontal disease.

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“…The immuno‐inflammatory response to microbial challenges is mainly driven by the activation of the NF‐κB signaling pathway. Compounds that can specifically inhibit NF‐κB activation may thus have a therapeutic potential for the treatment of inflammatory diseases, including periodontal diseases (Souza, Rossa, Garlet, Nogueira, & Cirelli, ). In this present study, we used the U937‐3xκ B‐LUC cell line to show that resveratrol prevents P. gingivalis ‐induced NF‐κB activation.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol attenuates the pathogenic and inflammatory properties of Porphyromonas gingivalis

Lagha

Andrian

Grenier

2019

Molecular Oral Microbiology

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Porphyromonas gingivalis has been strongly associated with chronic periodontitis, which affects tooth‐supporting tissues. This Gram‐negative anaerobic bacterium produces a repertoire of virulence factors that modulate tissue destruction directly or indirectly by the induction of inflammatory processes. The aim of this study was to investigate the effects of resveratrol, a major polyphenol found in grapes and wine, on the growth and virulence properties of P. gingivalis as well as on gingival keratinocyte tight junction integrity and the host inflammatory response. Resveratrol exhibited antibacterial activity that may result from damage to the bacterial cell membrane. Resveratrol also killed a pre‐formed P. gingivalis biofilm and reduced bacterial adherence to matrix proteins. In addition, resveratrol had a protective effect on the integrity of the keratinocyte tight junctions by inhibiting its breakdown by P. gingivalis. This may be related to the ability of resveratrol to inhibit the protease activities of P. gingivalis. Lastly, resveratrol reduced P. gingivalis‐mediated activation of the NF‐κB signaling pathway and attenuated TREM‐1 gene expression as well as soluble TREM‐1 secretion in monocytes. The effect on NF‐κB activation likely results from the ability of resveratrol to act as a PPAR‐γ agonist. In summary, the antibacterial, anti‐adherence, and antiprotease properties of resveratrol, as well as its ability to protect the gingival keratinocyte barrier and attenuate the inflammatory response in monocytes suggest that it may be a promising novel therapeutic agent for treating periodontal disease.

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Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease

Cited by 78 publications

References 86 publications

Bone biology & pathology moves on: from bone resorption to formation, the rise of new therapeutic opportunities and experimental tools

Bone biology & pathology moves on: from bone resorption to formation, the rise of new therapeutic opportunities and experimental tools

Effects of theaflavins on tissue inflammation and bone resorption on experimental periodontitis in rats

Resveratrol attenuates the pathogenic and inflammatory properties of Porphyromonas gingivalis

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