“…Studies focused on bone biology and pathology have been recurrent in the Journal of Applied of Science, highlighting the growing interest of the researchers in this expanding field. Interestingly, in recent editorials of the JAOS the impact of tissue environment and host response to regenerative processes were independently discussed 6 , 7 , 9 , and in this issue, three studies bring new pieces to the multifaceted puzzle comprised by bone regeneration process, allowing a more interconnected analysis of this process.…”