Effects of folk medicinal plant extract Ankaferd Blood Stopper® on early bone healing

İşler, Sabri Cemil; Demircan, Sabit; Çakarer, Sırmahan; Çebi, Zerrin; Keskin, Cengizhan; Soluk, Merva; Yüzbaşıoğlu, Emir

doi:10.1590/s1678-77572010000400015

Cited by 85 publications

(115 citation statements)

References 15 publications

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“…21 The accumulation of siderophages in the kidney tissue may be a sign of tissue repair in our study. Furthermore, a recent study has demonstrated that adding ABS on the pancreatic fluid produces aggregates of protein network resulting in a solid layer over the pancreatic fluid like a frozen gel with important in vitro biochemical alterations.…”

Section: Discussionsupporting

confidence: 49%

Histopathological Alterations in the Kidney Tissue Following Topical Ankaferd Hemostat Application in a Rat Renal Injury Model

Karakoç¹,

Akar²,

Aksu³

et al. 2012

UHOD

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Ankaferd Blood Stopper (ABS) is a novel topical hemostatic agent. ABS has been approved in Turkey for clinical hemorrhages, when the conventional control of bleeding by ligature and/or conventional hemostatic measures is ineffective. ABS has many cellular effects and could modulate numerous hemostatic proteins at the tissue and blood. ABS-induced formation of the protein network with vital erythroid aggregation covers the entire physiological hemostatic process. The aim of this study was to assess histopathological alterations due to topical ABS administration at the renal tissue level. Thirty-six Wistar rats weighing 70 to 80 gm were included into the study. The rats were divided into two groups as "the ABS-applied group" (ABS−G) and "the control group" (C−G). The animals in both groups were then again divided into the three subgroups of "postoperative (Postop.) 60th minutes", "Postop. 48th hours", and "Postop. 15th day". Therefore, there were six rats in each of the subgroups at the end of the analyses. The standard renal injury sites in the rats of ABS−G were applied 2 ml. of topical ABS, whereas 2 ml. of topical saline was applied to the renal injury sites of the rats in the C−G group. We detected significant erythrocyte aggregation and the accumulation of siderophages in the kidney tissue just after 60 minutes of ABS application persisting over 15 days. Our results indicated red blood cell accumulation and siderophages following the use of ABS are compatible with the suggested 'mechanism-of-action' of ABS that ABS-induced formation of the protein network with vital erythroid aggregation covers the entire physiological hemostatic process. Further experimental search is needed to find out the molecules inside the ABS protein library leading to the ABS-induced aggregation at the renal tissue level.

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Section: Discussionsupporting

confidence: 49%

Histopathological Alterations in the Kidney Tissue Following Topical Ankaferd Hemostat Application in a Rat Renal Injury Model

Karakoç¹,

Akar²,

Aksu³

et al. 2012

UHOD

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“…The effects of ABS in preventing liver lacerations, partial nephrectomies, air leakage into the lung, and bleeding have been demonstrated via animal studies (14)(15)(16)(17). In another animal study, İşler et al reported that ABS causes new bone formation and reductions in necrosis and inflammation in a rat tibial defect model (18).…”

Section: Discussionmentioning

confidence: 98%

New hemostatic agent: the effect of Ankaferd Blood Stopper on healing wounds in experimental skin incision model

Yüce¹,

Çandırlı²,

Yenıdünya³

et al. 2014

Turk J Med Sci

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Turkey is of great importance for the biodiversity of genus Onobrychis Adans. and hosts 55 species that are adapted to dry and poor environments. This study was conducted to evaluate 35 Onobrychis taxa in terms of 1000-seed weight, germination percentage, mean germination time, and hard and swollen seeds and to determine the suitability of mechanical scarification for dormancy breaking in species with hard or impermeable seed coats. Seed dormancy was detected in 19 of the investigated species and 14 of the endemic species. Germination percentages of these taxa ranged from 5.5% to 98.0%. The lowest germination rate (5.5%) and the highest hard seed rate (93.0%) were determined in Onobrychis lasiostachya Boiss. Increased germination and decreased hard seed rates were achieved using mechanical scarification with sandpaper in Onobrychis gracilis Besser. Germination of O. lasiostachya, Onobrychis oxyodonta Boiss., and Onobrychis podperae Sirj. increased after mechanical scarification. It was concluded that mechanical scarification is an effective method for improving germination of wild Onobrychis taxa.

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“…Besides its hemostatic activity, it possesses antiinflammatory actions, antimicrobial activity, antithrombin, antiplatelet, wound healing, and antioxidant characteristics, and antineoplastic properties in vitro, and it does not exhibit any side effects (1,3,5,18,19).…”

Section: Discussionmentioning

confidence: 99%

“…ankaferd.com). In relation to this issue, İşler et al (19) indicated that the application of ABS to tibia defects decreased the occurrence of inflammation and necrosis in the early bone healing period. Recently, Amanvermez et al (20) reported that the values of proinflammatory cytokines (e.g., TNF-α, IL-1β) were elevated in the postfracture first week according to the control (baseline), but circulating levels of these cytokines were found to be low after Ankaferd application to the fracture region.…”

Section: Discussionmentioning

confidence: 99%

Ankaferd Blood Stopper: Does it have a role in fracture healing?

Aygül¹,

Topuz

Okay³

et al. 2013

Turk J Med Sci

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High-pressure and ultrahigh-pressure metamorphic rocks crop out widely in the northern Aegean. In many instances their ages and tectonic setting are poorly constrained. Here we report newly discovered high-pressure rocks of continental crustal origin and of Late Cretaceous age southwest of the Marmara Sea. Th ey occur at the contact between the Rhodope-Strandja Zone in the north and the Sakarya Zone in the south.Th e Kemer Metamorphic Complex is composed mainly of mica schist, calcschist and marble with minor metabasite and serpentinite. Th e mica schists contain garnet, phengite (3.30-3.44 c.p.f.u), (±) paragonite, albite, epidote, calcite, chlorite and titanite. Th e high-pressure metamorphic origin of the mica schists is shown by the high silica contents of the white micas and by glaucophane inclusions in garnet. In the metabasites the mineral assemblage is garnet, barroisite, epidote, albite, titanite, quartz, phengite and chlorite; no evidence is left for the former presence of high-pressure minerals. Metamorphic conditions are constrained by mineral equilibria: a 560-640°C temperature at a minimum pressure of 10 kbar. Th e metamorphism is dated at 64-84 Ma by the Rb-Sr phengite-whole rock method.Th e Kemer Metamorphic Complex is in tectonic contact with an accretionary ophiolitic mélange consisting of limestone, basalt, serpentinite, greywacke, radiolarian chert and metabasite. Some of the metabasites in the mélange contain Na-amphibole and lawsonite, indicating a subduction origin. Th e ages of the limestone blocks in the mélange range from Late Triassic to Late Cretaceous and that of the radiolarite blocks from Middle Jurassic to Early Cretaceous, indicating an oceanic domain dating back to Late Triassic at least. Th e Kemer Metamorphic Complex and the Çetmi Mélange are intruded by a granodiorite of Early Eocene (52 Ma) age and are unconformably covered by a Late Eocene volcano-sedimentary succession.Th e lithology of the Kemer Metamorphic Complex resembles a continental margin rather than an oceanic accretionary complex. Th is and the presence of a Late Cretaceous magmatic arc in the north (Sredna-Gora-Pontide) suggest that the Kemer metamorphic rocks were initially deposited on the northern passive margin of the Sakarya Zone, which was subducted under the Rhodope-Strandja continental domain.

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Effects of folk medicinal plant extract Ankaferd Blood Stopper® on early bone healing

Cited by 85 publications

References 15 publications

Histopathological Alterations in the Kidney Tissue Following Topical Ankaferd Hemostat Application in a Rat Renal Injury Model

Histopathological Alterations in the Kidney Tissue Following Topical Ankaferd Hemostat Application in a Rat Renal Injury Model

New hemostatic agent: the effect of Ankaferd Blood Stopper on healing wounds in experimental skin incision model

Ankaferd Blood Stopper: Does it have a role in fracture healing?

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