Effect of 4% titanium tetrafluoride solution on the erosion of permanent and deciduous human enamel: an in situ/ex vivo study

Magalhães, Ana Carolina; Ríos, Daniela; Honório, Heitor Marques; Delbem, Alberto Carlos Botazzo; Buzalaf, Marília Afonso Rabelo

doi:10.1590/s1678-77572009000100011

Cited by 43 publications

(52 citation statements)

References 27 publications

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“…14 High-concentrated F applications have been considered very effective in reducing the enamel erosion. 6,20 The agents investigated contain approximately 22600 ppm F (varnish), 9000 ppm F (nanophosphate paste) and 900 ppm F (CPP-ACP paste), according to the manufacturers' information. Although the varnish contained the highest F concentration among the agents tested, according to our protocol, it showed no protective effect against enamel erosion.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of calcium nanophosphate and CPP-ACP agents on enamel erosion

et al. 2013

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The aim of this study was to assess the effect of different remineralizing agents on enamel microhardness (KHN) and surface topography after an erosive challenge. Forty-eight human enamel specimens (4 × 4 mm) were randomly assigned to 4 groups: control (no treatment), fluoride varnish, calcium nanophosphate paste and casein phosphopeptide-amorphous calcium phosphate paste (CPP-ACP). Both pastes were applied for 5 minutes, and fluoride varnish, for 24 h. Four daily erosive cycles of 5 minutes of immersion in a cola drink and 2 h in artificial saliva were conducted for 5 days. KHN readings were performed at baseline and after 5 days. The percentage of enamel hardness change (%KHN) was obtained after erosion. The surface topography was evaluated by atomic force microscopy (AFM). The data were tested using ANOVA, Tukey's and paired-T tests (p < 0.05). After an erosive challenge, there was no statistically significant difference between the control (96.8 ± 11.4 KHN / 72.4 ± 3.0 %KHN) and the varnish (91.7 ± 14.1 KHN / 73.4 ± 5.5 %KHN) groups. The nanophosphate group showed lower enamel hardness loss (187.2 ± 27.9 / 49.0 ± 7.9 %KHN), compared with the CPP-ACP group (141.8 ± 16.5 / 60.6 ± 4.0 %KHN), and both were statistically different from the varnish and the control groups. AFM images showed a rough surface for the control and the varnish groups, a non-homogeneous layer with globular irregularities for CPP-ACP, and a thick homogeneous layer for the nanophosphate group. None of the agents provided protection against the development of erosion; however, nanophosphate paste was able to reduce enamel surface softening after the erosive challenge.

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Section: Discussionmentioning

confidence: 99%

Protective effect of calcium nanophosphate and CPP-ACP agents on enamel erosion

et al. 2013

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“…The efficacy of TiF 4 to reduce carious demineralisation suggested that it might be also an effective agent in preventing erosive dental loss. In several recent in vitro 3,[11][12][13] and few in situ studies 14,15 it was shown that TiF 4 reduced dental erosion significantly and was more effective than sodium, amine or stannous fluoride.…”

Section: Introductionmentioning

confidence: 98%

TiF4 and NaF at pH 1.2 but not at pH 3.5 are able to reduce dentin erosion

Wiegand

Magalhães²,

Sener

et al. 2009

Archives of Oral Biology

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OBJECTIVE: This study aimed to analyse and compare the protective effect of buffered (pH 3.5) and native (pH 1.2) TiF(4) in comparison to NaF solutions of same pH on dentin erosion. DESIGN: Bovine samples were pretreated with 1.50% TiF(4) or 2.02% NaF (both 0.48M F) solutions, each with a pH of 1.2 and 3.5. The control group received no fluoride pretreatment. Ten samples in each group were eroded with HCl (pH 2.6) for 10x60s. Erosion was analysed by determination of calcium release into the acid. Additionally, the surface and the elemental surface composition were examined by scanning electron microscopy (two samples in each group) and X-ray energy-dispersive spectroscopy in fluoridated but not eroded samples (six samples in each group). Cumulative calcium release (nmol/mm(2)) was statistically analysed by repeated measures ANOVA and one-way ANOVA at t=10min. RESULTS: TiF(4) and NaF at pH 1.2 decreased calcium release significantly, while TiF(4) and NaF at pH 3.5 were not effective. Samples treated with TiF(4) at pH 1.2 showed a significant increase of Ti, while NaF pretreatment increased F concentration significantly. TiF(4) at pH 1.2 led to the formation of globular precipitates occluding dentinal tubules, which could not be observed on samples treated with TiF(4) at pH 3.5. NaF at pH 1.2 but not at pH 3.5 induced the formation of surface precipitates covering dentinal tubules. CONCLUSION: Dentin erosion can be significantly reduced by TiF(4) and NaF at pH 1.2, but not at pH 3.5.1 TiF 4 and NaF at pH 1.2 but not at pH 3.5 are able to reduce dentin erosion Objective: This study aimed to analyse and compare the protective effect of buffered (pH 3.5) and native (pH 1.2) TiF 4 in comparison to NaF solutions of same pH on dentin erosion.Design: Bovine samples were pretreated with 1.50% TiF 4 or 2.02% NaF (both 0.48 M F) solutions, each with a pH of 1.2 and 3.5. The control group received no fluoride pretreatment.Ten samples in each group were eroded with HCl (pH 2.6) for 10 x 60s. Erosion was analysed by determination of calcium release into the acid. Additionally, the surface and the elemental surface composition were examined by scanning electron microscopy (two samples in each group) and X-ray energy-dispersive spectroscopy in fluoridated but not eroded samples (six samples in each group). Cumulative calcium release (nmol/mm 2 ) was statistically analysed by repeated measures ANOVA and one-way ANOVA at t = 10 min.Results: TiF 4 and NaF at pH 1.2 decreased calcium release significantly, while TiF 4 and NaF at pH 3.5 were not effective. Samples treated with TiF 4 at pH 1.2 showed a significant increase of Ti, while NaF pretreatment increased F concentration significantly. TiF 4 at pH 1.2 led to the formation of globular precipitates occluding dentinal tubules, which could not be observed on samples treated with TiF 4 at pH 3.5. NaF at pH 1.2 but not at pH 3.5 induced the formation of surface precipitates covering dentinal tubules.Conclusion: Dentin erosion can be significantly reduced by TiF 4 and NaF at p...

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“…Intrinsic sources are chronic vomiting and gastroesophageal reflux that persist for a long period [9] and affect mainly the palatal and incisal areas of dental elements [10]. Those of extrinsic origin come from the environment (acid pH of swimming pools), chronic use of medications (ascorbic acid, acetylsalicylic acid) and diet (unruly consumption of acidic foods and drinks) [9].…”

Section: Introductionmentioning

confidence: 99%

“…Those of extrinsic origin come from the environment (acid pH of swimming pools), chronic use of medications (ascorbic acid, acetylsalicylic acid) and diet (unruly consumption of acidic foods and drinks) [9].…”

Section: Introductionmentioning

confidence: 99%

Influence of Soft Drink Intake on the SalivarypH of Schoolchildren

Almenara

Rebouças

Cavalli

et al. 2016

Pesqui. bras. odontopediatria clín. integr.

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Objective: To evaluate the influence of Coca-Cola ® consumption on the salivary pH of 12-year old children. Material and Methods: The convenience sample was composed of forty-five 12-year old students of both genders from public schools of Itatiba, state of São Paulo, Brazil. Salivary pH was measured with pH colorimetric tape indicator (Merck). The reading of the colorimetric method was made by an experienced evaluator under uniform lighting conditions. The colorimetric tape was positioned in the back of the student's tongue, which remained with the mouth shut for 30 Seconds. For control, the first measurement (T0) was performed before the intake of the soft drink (baseline pH). Subsequently, students were instructed to slowly drink 100 ml of Coca-Cola ® using a plastic disposable cup. Immediately after ingestion, the pH was measured again with the colorimetric tape (t1). The oral pH values were also measured 5 minutes (t2), 10 minutes (t3) and 15 minutes (t4) after the soft drink intake, keeping the tape positioning always the same in all measurements. The statistical SAS software was used for data analysis. Comparisons of oral pH values at different times were performed by the Tukey-Kramer test adopting 5% significance level. Results: Immediately after soft drink intake, the salivary pH significantly decreased (pH = 6.26) (p <0.05) compared to baseline (pH = 7.23) (p <0.05). Fifteen minutes after ingestion, although an increase in the pH was observed (pH = 6.64), it had not yet returned to baseline (T0) (p <0.05). Conclusion: Coca-Cola ® intake caused a significant reduction in salivary pH, without, however, reaching critical pH for enamel demineralization.

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Effect of 4% titanium tetrafluoride solution on the erosion of permanent and deciduous human enamel: an in situ/ex vivo study

Cited by 43 publications

References 27 publications

Protective effect of calcium nanophosphate and CPP-ACP agents on enamel erosion

Protective effect of calcium nanophosphate and CPP-ACP agents on enamel erosion

TiF4 and NaF at pH 1.2 but not at pH 3.5 are able to reduce dentin erosion

Influence of Soft Drink Intake on the SalivarypH of Schoolchildren

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