Biophysiologic considerations in cryoablation: a practical mechanistic molecular review

Maccini, Michael; Sehrt, Daniel; Pompeo, Alexandre; Chicoli, Felipe Ambrosio; Molina, Wilson; Kim, Fernando J.

doi:10.1590/s1677-55382011000600002

Cited by 33 publications

(25 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Percutaneous cryoablation is believed to ablate cancer cells by several mechanisms including direct cell injury, vascular injury and ischemia, apoptosis, and immunomodulation [80,81]. The advantages of cryoablation, compared with other ablative techniques, are as follows: (1) it allows for visualization of the ‘ice ball' using noncontrast computed tomography [82], ultrasound [83], or magnetic resonance imaging [84] monitoring, which permits more precise evaluation of the ablated zone in real time; (2) it causes less pain and can be performed under moderate sedation, making it feasible for patients who are poor candidates for anesthesia [85], and (3) it maintains cellular integrity of connective tissue in the vessel walls, or adjacent visceral linings, such as the gallbladder, bowel, and kidney [86].…”

Section: Local Ablative Therapymentioning

confidence: 99%

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

Shi

Zhai

2016

Gastrointest Tumors

View full text Add to dashboard Cite

Background: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. Hepatic resection and liver transplantation are considered to be the preferred treatment for HCC. However, as novel therapeutic options such as image-guided locoregional therapies have emerged and been refined, the manner in which HCC is treated has changed dramatically compared with what it was considered just 2 decades earlier. Summary: This study reviews the current results of various image-guided locoregional therapies for treating HCC, especially focusing on thermal ablative and transarterial techniques. Key Message: Advances in image-guided locoregional therapies, including local ablative therapy and transarterial therapy, have led to a major breakthrough in the management of HCC. Both survival rates and cure rates of patients with HCC have improved markedly since the introduction of these techniques. Practical Implications: Radiofrequency ablation is currently considered as an alternative to surgical resection for patients with early-stage HCC. A newer technique of ablation such as microwave ablation is increasingly being used, especially for large HCC. Transarterial chemoembolization has become a standard care for asymptomatic patients with multinodular tumors in intermediate-stage disease, and transarterial radioembolization has become the method of choice in HCC cases with portal vein thrombosis. Moreover, combination treatment modalities, such as thermal-based ablation combined with transarterial chemoembolization or ¹²⁵I seed implant brachytherapy, may further broaden their clinical indications for HCC. Moreover, use of localized radiation in combination with thermal ablation has been reported to improve tumor control and long-term survival.

show abstract

Section: Local Ablative Therapymentioning

confidence: 99%

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

Shi

Zhai

2016

Gastrointest Tumors

View full text Add to dashboard Cite

show abstract

“…A variety of local, intratumoral therapies have been developed to provide advantages over surgery and chemo-radiation, that include minimal invasiveness, minimal side effects, and shorter hospitalizations. [1][2][3][4] These therapies are based on different physical mechanisms and ablation techniques including microwave, [5][6][7] focused ultrasound, [8][9][10] radiofrequency, 11,12 and cryoablation [13][14][15] therapies. The disadvantages of these therapies include limited specificity, limited delivery, and tumor recurrence.…”

Section: Introductionmentioning

confidence: 99%

A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regression

Green¹,

Crockett²,

Martyshkin³

et al. 2014

IJN

View full text Add to dashboard Cite

Purpose Nanoparticle (NP)-enabled near infrared (NIR) photothermal therapy has realized limited success in in vivo studies as a potential localized cancer therapy. This is primarily due to a lack of successful methods that can prevent NP uptake by the reticuloendothelial system, especially the liver and kidney, and deliver sufficient quantities of intravenously injected NPs to the tumor site. Histological evaluation of photothermal therapy-induced tumor regression is also neglected in the current literature. This report demonstrates and histologically evaluates the in vivo potential of NIR photothermal therapy by circumventing the challenges of intravenous NP delivery and tumor targeting found in other photothermal therapy studies. Methods Subcutaneous Cal 27 squamous cell carcinoma xenografts received photothermal nanotherapy treatments, radial injections of polyethylene glycol (PEG)-ylated gold nanorods and one NIR 785 nm laser irradiation for 10 minutes at 9.5 W/cm 2 . Tumor response was measured for 10–15 days, gross changes in tumor size were evaluated, and the remaining tumors or scar tissues were excised and histologically analyzed. Results The single treatment of intratumoral nanorod injections followed by a 10 minute NIR laser treatment also known as photothermal nanotherapy, resulted in ~100% tumor regression in ~90% of treated tumors, which was statistically significant in a comparison to the average of all three control groups over time ( P <0.01). Conclusion Photothermal nanotherapy, or intratumoral nanorod injections followed by NIR laser irradiation of tumors and tumor margins, demonstrate the potential of NIR photothermal therapy as a viable localized treatment approach for primary and early stage tumors, and prevents NP uptake by the reticuloendothelial system.

show abstract

“…Contrary to the four precedent therapies (RFA, MWA, HIFU, and LA), the cryotherapy uses a low temperature below zero to create a freezing zone and generate the destruction of the selected region [99]. It uses extremely low lethal temperature < -20⁰C.…”

Section: Cryoablationmentioning

confidence: 99%

Thermal Therapy Modalities for Cancer Treatment: A Review and Future Perspectives

Mellal¹,

Oukaira²,

Kengene³

et al. 2017

Appl Sci Res Rev

View full text Add to dashboard Cite

Biophysiologic considerations in cryoablation: a practical mechanistic molecular review

Cited by 33 publications

References 14 publications

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regression

Thermal Therapy Modalities for Cancer Treatment: A Review and Future Perspectives

Contact Info

Product

Resources

About