Thermal Therapy Modalities for Cancer Treatment: A Review and Future Perspectives

Mellal, Idir; Oukaira, Aziz; Kengene, Emmanuel; Lakhssassi, Ahmed

doi:10.21767/2394-9988.100064

Cited by 25 publications

(18 citation statements)

References 79 publications

(114 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HT has been shown to inhibit the DNA repair, improve oxygenation, enhance the delivery of antineoplastic drugs [2], and induce anti-tumor immunity [3,4]. Several technologies have been developed to administer HT for cancer treatment [5][6][7][8][9][10][11][12][13]. In pelvic cancers, the addition of HT to RT can increase complete response rates (CRRs), partial response rates (PRRs) and improve overall survival [3,14,15].…”

Section: Introductionmentioning

confidence: 99%

Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model

Zhu

Partanen

Talcott

et al. 2019

International Journal of Hyperthermia

View full text Add to dashboard Cite

2019) Feasibility and safety assessment of magnetic resonance-guided highintensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine modelABSTRACT Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided highintensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40-45 C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 C (±1 ) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (T avg ) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 C, the average 30-min T avg variation was 0.80 ± 0.17 C, and the maximum difference between T avg and the 10th-or 90th-percentile temperature averaged 2.01 ± 0.44 C. The average time to reach !41 C and cool to 40 C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients. ARTICLE HISTORY

show abstract

Section: Introductionmentioning

confidence: 99%

Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model

Zhu

Partanen

Talcott

et al. 2019

International Journal of Hyperthermia

View full text Add to dashboard Cite

show abstract

“…Therapeutic applications of heat date back to the writing of Hippocrates [Habash et al, ]. Modern thermal therapy emerged in the mid‐1960s [Hahn, ], and now its main application is in oncology [Mellala et al, ]. At the cellular level, heating induces a complex cascade of phenomena, which may lead to cell death through different pathways.…”

Section: Introductionmentioning

confidence: 99%

“…Different power sources have been used to induce heating in biological tissues, including ultrasound and various bands of the electromagnetic spectrum, i.e. radiofrequency (RF), microwave (MW), ultraviolet (photothermal therapy), and light (lasers) [Mellal et al, ]. In the MW range, devices used for thermal ablation generally operate in the Industrial Scientific Medical (ISM) bands around 434 MHz, 915 MHz, and 2.45 GHz.…”

Section: Introductionmentioning

confidence: 99%

Millimeter‐Wave Heating in In Vitro Studies: Effect of Convection in Continuous and Pulse‐Modulated Regimes

Orlacchio

Алексеев

Nikolayev

et al. 2019

Bioelectromagnetics

View full text Add to dashboard Cite

Shallow penetration of millimeter waves (MMW) and non-uniform illumination in in vitro experiments result in a non-uniform distribution of the specific absorption rate (SAR). These SAR gradients trigger convective currents in liquids affecting transient and steady-state temperature distributions. We analyzed the effect of convection on temperature dynamics during MMW exposure in continuous-wave (CW) and pulsed-wave (PW) amplitude-modulated regimes using microthermocouples. Temperature rise kinetics are characterized by the occurrence of a temperature peak that shifts to shorter times as the SAR of the MMW exposure increases and precedes initiation of convection in bulk. Furthermore, we demonstrate that the liquid volume impacts convection. Increasing the volume results in earlier triggering of convection and in a greater cooling rate after the end of the exposure. In PW regimes, convection strongly depends on the pulse duration that affects the heat pulse amplitude and cooling rate. The latter results in a change of the average temperature in PW regime. Bioelectromagnetics. 2019;40:553-568.

show abstract

“…In addition, the duration, frequency, and the number of chemotherapy or radiation therapy cycles produce negative side effects that tend to gradually get worse over time. Based on these findings, researchers have developed further cancer therapies to improve the effectiveness of treatments while reducing undesired side effects, such as immunotherapy [ 12 , 13 ], hormone therapy [ 14 ], gene therapy [ 15 , 16 ], cryotherapy [ 17 ], targeted cancer therapies [ 18 , 19 ], stem cell transplant [ 20 , 21 ], thermal therapy [ 22 , 23 ], and photodynamic therapy [ 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Cyclodextrins in Anticancer Photodynamic Therapy Treatment

et al. 2018

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is mainly used to destroy cancerous cells; it combines the action of three components: a photoactivatable molecule or photosensitizer (PS), the light of an appropriate wavelength, and naturally occurring molecular oxygen. After light excitation of the PS, the excited PS then reacts with molecular oxygen to produce reactive oxygen species (ROS), leading to cellular damage. One of the drawbacks of PSs is their lack of solubility in water and body tissue fluids, thereby causing low bioavailability, drug-delivery efficiency, therapeutic efficacy, and ROS production. To improve the water-solubility and/or drug delivery of PSs, using cyclodextrins (CDs) is an interesting strategy. This review describes the in vitro or/and in vivo use of natural and derived CDs to improve antitumoral PDT efficiency in aqueous media. To achieve these goals, three types of binding modes of PSs with CDs are developed: non-covalent CD–PS inclusion complexes, covalent CD–PS conjugates, and CD–PS nanoassemblies. This review is divided into three parts: (1) non-covalent CD-PS inclusion complexes, covalent CD–PS conjugates, and CD–PS nanoassemblies, (2) incorporating CD–PS systems into hybrid nanoparticles (NPs) using up-converting or other types of NPs, and (3) CDs with fullerenes as PSs.

show abstract

Thermal Therapy Modalities for Cancer Treatment: A Review and Future Perspectives

Cited by 25 publications

References 79 publications

Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model

Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model

Millimeter‐Wave Heating in In Vitro Studies: Effect of Convection in Continuous and Pulse‐Modulated Regimes

Use of Cyclodextrins in Anticancer Photodynamic Therapy Treatment

Contact Info

Product

Resources

About