Renal cell carcinoma with thrombus in the inferior vena cava: extracorporeal circulation and deep hypothermia without open-chest surgery

D’Ancona, Carlos Arturo Levi; Petrucci, Orlando; Otsuka, Rodrigo

doi:10.1590/s1677-55382005000100009

Cited by 3 publications

(1 citation statement)

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“…[2][3][4][5][6][7][8] Although the administration of transdermal fentanyl with controlled heating might have the advantage of timely treatment of breakthrough pain in patients with cancer, 2) it is important to consider and to estimate the increase of permeation by external heating in situations from daily life, such as bathing, saunas and electric blankets, because TDSs are generally expected for drugs administered over a long period of time.…”

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confidence: 99%

The Effects of External Heating on the Permeation of Oxybutynin through Human Epidermal Membrane

Mizushima

Inoue

Ishizuka

2007

Biological & Pharmaceutical Bulletin

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The transdermal delivery system (TDS) of oxybutynin (OXY) is widely used for the treatment of overactive bladder patients. This report aimed to assess the effect of external heating on the pharmacokinetics of OXY after transdermal administration. Franz-type diffusion cell experiments at room temperature, 36 and 45°C were performed to estimate the permeations of OXY through human epidermal membrane with an isosorbide dinitrate (ISDN) formulation as a reference. The fluxes of OXY at 36 and 45°C were only approximately 1.2-fold higher than that at room temperature, while those of ISDN with heating were more than 2.5 times as high as that without heating (pϽ0.001). These results indicate that the influence of heating on the permeation of OXY from the TDS of OXY may be minimal.

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confidence: 99%