Primary lymphoma of the bladder

Leite, Kátia Ramos Moreira; Bruschini, Homero; Câmara-Lopes, Luiz H.

doi:10.1590/s1677-55382004000100009

Cited by 13 publications

(22 citation statements)

References 4 publications

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“…In conclusion, primary low-grade MALT lymphoma of the bladder represents a rare malignancy with excellent prognosis if detected at an early stage [5,7,13,14,38]. For this reason, practitioners should know about this entity and its presentation.…”

Section: Discussionmentioning

confidence: 94%

Case Report about a Primary Bladder Lymphoma

Combaz¹,

Kühn²

2017

Int Arch Urol Complic

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Primary isolated bladder lymphoma represents around 0.2% of all extranodal Non-Hodgkin-Lymphoma and less than 1% of all bladder tumours. Clinical representation may be unspecific and correct diagnosis is essential for the appropriate treatment. We expose the case of a patient with a primary B-cell bladder lymphoma with normal cystoscopy. Case report:A 67-year-old patient presented with lower urinary tract infections, overactive bladder with urinary incontinence as well as haematuria susceptible for bladder carcinoma. Urine sediment, cytologie, abdominal-and kidney ultrasound as well as a CT scan did not lead to a conclusive diagnosis. Surprisingly, cystoscopy did not demonstrate any tumourous lesions and urine cytology revealed free of malignant cells. Cold four-quadrant cut biopsies finally did reveal the presence of a primary B-cell lymphoma. After a four weeks' antibody treatment of Rituximab (Mabthera) the patient showed subjective improvement and lower urinary tract symptoms disappeared. Clinical follow-up as well as repeat cystoscopic biopsies were undertaken every six months. After a follow-up period of nearly three years the patient is still in complete remission. Urinary tract infections and incontinence as well as OAB symptoms disappeared entirely.Discussion: Haematuria was the main clinical finding in the current case of primary bladder lymphoma. Uneventful radiologic examinations lead to the necessity of bladder biopsies without any macroscopic pathologic findings. We present the exceedingly rare case of a primary bladder lymphoma without any characteristic lesions in the bladder lumen. For this reason, cystoscopic four quadrant biopsies should be used largely. Biopsies are essential leading to the correct diagnosis and finally successful treatment. Single antibody therapy with Rituximab is an option in selected cases as the one presented and can be used as un therapeutic option.

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Section: Discussionmentioning

confidence: 94%

Case Report about a Primary Bladder Lymphoma

Combaz¹,

Kühn²

2017

Int Arch Urol Complic

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“…In the present case, a partial cystectomy and resection of the lower ureter were performed in order to relieve the symptoms of obstruction and to obtain samples for histopathological examination. Complete resection of the bladder tumor or even radical cystectomy are considered unnecessary, as the tumor often responds favorably to chemotherapy, of which the CHOP regimen is the most widely used protocol (10,11). The addition of rituximab in CD20-positive cases, is recommended to be standard practice, due to the therapeutic benefit provided …”

Section: Discussionmentioning

confidence: 99%

Malignant lymphoma occurring simultaneously in the urinary bladder wall and bilateral renal parenchyma: A case report

Min

Geng

et al. 2015

Oncology Letters

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Abstract.A 67-year-old man was admitted to hospital with acid regurgitation, acute right lower abdominal pain and mild fever. Multiple suspicious mass lesions were detected in the patient's kidneys, the right side wall of his bladder and the right lower ureter, using CT urography and PET-CT. He underwent palliative surgery of the bladder and percutaneous renal biopsy. Postoperative histopathological examination and immunohistochemical staining indicated that the tumor was consistent with diffuse large B-cell lymphoma (DLBCL). Although DLBCL is by far the most common type of non-Hodgkin's lymphoma, it is rare for DLBCL to simultaneously involve the kidneys, bladder and the lower ureteric tract.

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“…The tumour occurs 6.5 times more frequently in women than in men and the mean age of affected patients is 64 years (range 20 − 85 years). 11 A history of chronic cystitis has been shown to be a preliminary feature in some cases of primary bladder lymphoma, with approximately 20% of patients presenting with such a history. 12,13 A review of the current English language medical literature identified only four cases of primary T-cell lymphoma of the urinary bladder (including the present case) ( Table 1).…”

Section: Discussionmentioning

confidence: 99%