Antibiotic prophylaxis in prostate biopsy: a comparative randomized clinical assay between ciprofloxacin, norfloxacin and chloramphenicol

Tobias-Machado, Marcos; Corrêa, Thiago Domingos; Barros, Emília L de; Wroclawski, Eric Roger

doi:10.1590/s1677-55382003000400005

Cited by 21 publications

(13 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our group of patients, likewise in the other authors , cover of fluoroquinolones lasted 3 days, followed by the minimal amount of infectious complications (7.6%). The prebioptis antibiotic prophylaxis include one-or three-day regimen (19,20). Aron et al (21) published a comparative study, which revealed significantly lower incidence of infectious complications in patients covered by ciprofloxacine than in placebo.…”

Section: Discussionmentioning

confidence: 99%

Complications of Transrectal Prostate Biopsy

Cech¹,

Ľupták²

2014

Acta Medica Martiniana

View full text Add to dashboard Cite

A b s t r a c t Objective: The aim of our study is to evaluate complications in patients who underwent a Transrectal Ultrasound Guided Prostate Biopsy (TRUS BP) at the Department of Urology of JFM CU and UHM in 2007-2008 and at the Department of Urology in Bojnice Hospital in 2009-2012. Methodology, disclosures: In our study, patients with positive digital rectal examination (DRE) and/or with higher prostate specific antigen (PSA) levels (>4 ng/ml) are included. We excluded patients with PSA levels greater than 50ng/ml, as well as patients with less than 8 biopsy cores. The number of examined patients fulfilling the criteria was 474. An average age of them was 66.3 years (SD±8.3years). As an antibacterial prophylaxis, the patients were given fluoroquinolons in a dose of 500mg twice a day during a 3-day course of antibiotics, while the first dose was given one day before the procedure. In high risk patients, we used a single intramuscular dose of gentamycin 160mg right before the procedure followed by fluoroquinolons for the next five days.Results: The most severe complication was vasovagal reaction, which occurred in 9 (1.9%) cases. Haematuria occurred in 122 (25.7%) cases up to 3 days and in 10 (2.1%) patients up to 7 days. Six patients (1.3%) required hospital admission for severe haematuria. Dysuria occurred in 71 patients (15%). Rectal bleeding occurred in 90 (19%) cases with an average 2 days of bleeding, from which 7 patients were admitted to hospital and administered haemostyptics. From the mentioned count, 2 (0.4%) patients underwent a rectal tamponade and one (0.2%) patient with arterial bleeding underwent an arterial ligation of a stricken artery. Haemospermia occurred in 71 (15%) cases. 23 (4.9%) patients suffered fever above 38°C, within whom in 7 (1.5%) cases was microscopicaly proven urinary tract infection requiring hospitalisation lasting 7 days on average. Sepsis occurred in 3 (0.6%) patients, symptomatic bacterial prostatitis in 6 (1.2%) cases and urinary retention occurred in one (0.2%) patient. There was not any significant higher amount of complications in between 8-core and 10-core biopsy (P=0.26), not even in between 8-core and 12-core biopsy (P=0.32).Conclusion: TRUS PB is a safe procedure with quite a low risk of complications. An important moment is a close monitoring right after the procedure. The most of the complications may persist for around two weeks and are treated conservatively without persistent effects. Prophylaxis with broad spectrum antibiotics may provide an adequate coverage and lowers the risk of infectious complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Complications of Transrectal Prostate Biopsy

Cech¹,

Ľupták²

2014

Acta Medica Martiniana

View full text Add to dashboard Cite

show abstract

“…Al analizar la eficacia de la monodosis frente a la pauta corta, en tres de los trabajos revisados no se observaron diferencias estadísticamente significativas entre ambas pautas 9,25,30 . Sólo en un trabajo se objetivó que la pauta corta era clínica y analíticamente superior a la monodosis 31 .…”

Section: Discussionunclassified

“…Diferentes autores han comparado las complicaciones infecciosas de las quinolonas administradas en monodosis frente a las pautas cortas y no han observado diferencias entre ambos grupos 9,25,30 . Sólo un trabajo de los revisados recoge diferencias significativas a favor de la pauta corta, que presentó una menor tasa de fiebre y urocultivos comparada con la monodosis 32 .…”

Section: Pauta Larga Corta O Monodosisunclassified

Profilaxis antibiótica en la biopsia transrectal de próstata

2009

View full text Add to dashboard Cite

“…Two prospective studies also indicate that a longer duration of antimicrobial prophylaxis might be more effective than a shorter one. In a randomized comparison of two different dose regimens of ciprofloxacin in 257 patients undergoing TRNBP, complications occurred in 3.1% of those receiving a single dose of ciprofloxacin and in 2.1% of those receiving three daily doses, although this difference was not statistically significant [15]. Both ciprofloxacin regimens were better than 3 days of prophylaxis with chloramphenicol or norfloxacin (18.3% and 10.5% complication rates, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…Although the reported duration of prophylaxis is not consistent with the published recommendations (one dose by mouth or i.v. before surgery, with additional doses given for prolonged procedures) [5], incidences of infectious complications associated with TRNBP were lower with a longer duration of therapy in some but not all studies [12–16]. In at least three studies, the first dose was given the day before the procedure [12,17,18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of a 3‐day with a 1‐day regimen of an extended‐release formulation of ciprofloxacin as antimicrobial prophylaxis for patients undergoing transrectal needle biopsy of the prostate

et al. 2007

View full text Add to dashboard Cite

As defined by bacteriological success in the population assessed for microbiological efficacy, prophylaxis with one dose of ciprofloxacin XR was statistically no worse than a 3-day regimen. However, in all efficacy analyses, bacteriological and clinical success rates were consistently lower for the 1-day than for the 3-day treatment. Thus, for selected patients undergoing TRNBP, there might be a role for 3-day preventive therapy with ciprofloxacin XR.

show abstract

Antibiotic prophylaxis in prostate biopsy: a comparative randomized clinical assay between ciprofloxacin, norfloxacin and chloramphenicol

Abstract: Schemes using ciprofloxacin presented better results in prophylaxis previously to prostate biopsy. We recommend using a single dose of ciprofloxacin due to its posologic ease and low cost, associated with a therapeutic response equivalent to 3-day regimens.

Cited by 21 publications

References 14 publications

Complications of Transrectal Prostate Biopsy

Complications of Transrectal Prostate Biopsy

Profilaxis antibiótica en la biopsia transrectal de próstata

Comparison of a 3‐day with a 1‐day regimen of an extended‐release formulation of ciprofloxacin as antimicrobial prophylaxis for patients undergoing transrectal needle biopsy of the prostate

Contact Info

Product

Resources

About