Prostate specific membrane antigen (PSMA) and Prostate Cancer Staging: is our current conventional staging obsolete?

Céspedes, Melissa Segura; Radtke, Jan Philipp; Cathelineau, Xavier; Sánchez-Salas, Rafael

doi:10.1590/s1677-5538.ibju.2020.0997

Cited by 2 publications

(2 citation statements)

References 48 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prostate-specific membrane antigen ligand positron emission tomography/computed tomography is the current precision imaging examination system for PCa. Further studies are warranted to determine whether optimizing this imaging examination prior to biopsy could potentially provide a reference for the choice of biopsy mode ( 28 - 30 ).…”

Section: Discussionmentioning

confidence: 99%

Is it necessary for all patients with suspicious lesions undergo systematic biopsy in the era of MRI-TRUS fusion targeted biopsy?

Lv¹,

Wang²,

Wang³

et al. 2023

Int. braz j urol.

View full text Add to dashboard Cite

Purpose Targeted biopsy (TB) combined with systematic biopsy (SB) is an optimized mode of prostate biopsy but can often lead to oversampling and overdiagnosis accompanied by potential biopsy-related complications and patient discomfort. Here, we attempted to reasonably stratify the patient population based on multi-parameter indicators with the aim of avoiding unnecessary SB. Methods In total, 340 biopsy-naïve men with suspected lesions, prostate-specific antigen (PSA) < 20 ng/mL and prostate imaging-reporting and data system (PI-RADS) ≥ 3 enrolled for study underwent both TB and SB. The primary outcome was to determine independent predictors for a valid diagnosis, assuming that only TB was performed and SB omitted (defined as mono-TB), taking TB + SB as the reference standard. The secondary outcomes were exploration of the predictive factors of mono-TB and TB + SB in detection of prostate cancer (PCa) and clinically significant PCa (csPCa). Results The mean PSA density (PSAD) of patient group was 0.27 ng/mL/mL. Multiparametric MRI PI-RADS scores were 3-5 in 146 (42.94%), 105 (30.88%), and 89 (26.18%) cases, respectively. PCa and csPCa were detected in 178/340 (52.35%) and 162/340 (47.65%) patients, respectively. Overall, 116/178 (65.17%) patients diagnosed with PCa displayed pathological consistencies between mono-TB and TB + SB modes. PSAD and PI-RADS were independent predictors of valid diagnosis using mono-TB. Conclusions PSAD combined with PI-RADS showed utility in guiding optimization of the prostate biopsy mode. Higher PSAD and PI-RADS values were associated with greater confidence in implementing mono-TB and safely omitting SB, thus effectively balancing the benefits and risks.

show abstract

Section: Discussionmentioning

confidence: 99%

Is it necessary for all patients with suspicious lesions undergo systematic biopsy in the era of MRI-TRUS fusion targeted biopsy?

Lv¹,

Wang²,

Wang³

et al. 2023

Int. braz j urol.

View full text Add to dashboard Cite

show abstract

“…Establishing an adequate perception of the disease, while promoting protective factors, and educating patients on healthy lifestyles positively impacts the health system because of the decreased economic impact and greater adherence to treatment. Patients undergoing surgery, hormone therapy, and radiation therapy with joint monitoring of their lifestyle and risk factors may lower health costs and minimize the morbidity related to treatment (5,55,70,99,106).…”

Section: Author's Proposalmentioning

confidence: 99%

Impact of lifestyle in prostate cancer patients. What should we do?

et al. 2022

View full text Add to dashboard Cite

Objective: This review aimed to analyze interventions raised within primary and tertiary prevention concerning the disease's incidence, progression, and recurrence of Prostate Cancer (PCa). Priority was given to the multidisciplinary approach of PCa patients with an emphasis on modifiable risk factors. Materials and Methods: We conducted a comprehensive literature review in the following databases: Embase, Central, and Medline. We included the most recent evidence assessing cohort studies, case-control studies, clinical trials, and systematic reviews published in the last five years. We only included studies in adults and in vitro or cell culture studies. The review was limited to English and Spanish articles. Results: Preventive interventions at all levels are the cornerstone of adherence to disease treatment and progression avoidance. The relationship in terms of healthy lifestyles is related to greater survival. The risk of developing cancer is associated to different eating habits, determined by geographic variations, possibly related to different genetic susceptibilities. Discussion: PCa is the second most common cancer in men, representing a leading cause of death among men in Latin America. Prevention strategies and healthy lifestyles are associated with higher survival rates in PCa patients. Also, screening for anxiety and the presence of symptoms related to mood disorders is essential in the patient's follow-up concerning their perception of the condition.

show abstract

Prostate specific membrane antigen (PSMA) and Prostate Cancer Staging: is our current conventional staging obsolete?

Cited by 2 publications

References 48 publications

Is it necessary for all patients with suspicious lesions undergo systematic biopsy in the era of MRI-TRUS fusion targeted biopsy?

Is it necessary for all patients with suspicious lesions undergo systematic biopsy in the era of MRI-TRUS fusion targeted biopsy?

Impact of lifestyle in prostate cancer patients. What should we do?

Contact Info

Product

Resources

About