Role of native Thiol, total Thiol and dynamic Disulphide in diagnosis of patient with prostate cancer and prostatitis

Solakhan, Mehmet; Çiçek, Hülya; Orhan, Nuri; Yıldırım, Mustafa

doi:10.1590/s1677-5538.ibju.2018.0469

Cited by 13 publications

(11 citation statements)

References 27 publications

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“…GSH is converted to its dimer GSSG after reducing the target molecules. Therefore, the GSH/GSSG ratio indicates the oxidative state [ 44 ]. Moreover, thiol-disulphide balance plays an important role in health and disease.…”

Section: Discussionmentioning

confidence: 99%

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

et al. 2022

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Atopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an increasing prevalence and pathogenesis that are not fully understood. Emerging evidence suggests that oxidative stress plays a role in AD and CU. The aim of the single-center cross-sectional study was to compare markers of oxidative stress in 21 patients with AD, and 19 CU patients. The products of protein oxidation, total antioxidant capacity (TAC), and markers of lipid peroxidation were estimated in the serum. AD patients had a higher level of advanced protein oxidation products and a lower level of thiol groups than healthy participants. However, CU patients had statistically higher levels of AOPP and 3-nitrotyrosine than healthy subjects. The level of thiol groups and serum TAC decreased significantly in patients with CU. There was no difference in serum concentration of lipid peroxidation products, Amadori products, ratio of reduced to oxidized glutathione, and ability of albumin to binding cobalt between AD or CU patients compared to healthy subjects. We found a moderate positive significant correlation between AOPP and age in patients with AD. In patients with CU, TAC was negatively correlated with age. These results may shed light on the etiopathogenesis of AD or CU, and confirm an oxidative burden in these patients. Furthermore, our study could be useful in developing new therapeutic methods that include using antioxidants in dermatological diseases.

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Section: Discussionmentioning

confidence: 99%

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

et al. 2022

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“…There are many studies that reveal the effects of oxidative stress on chronic prostatitis, and oxidative stress markers have been identified in the urine and genital secretions of patients with prostatitis [10][11][12][13]. Studies have been conducted to explore the relationship between oxidative stress and prostate cancer, BPH and prostate inflammation [14]. Normal oxidative stress markers such as nitric oxide synthases and malonyl dialaldehyde are still in use today.…”

Section: Discussionmentioning

confidence: 99%

Value of serum thiol/disulphide in chronic prostatitis

Öncel¹,

Salar²,

Özbay³

et al. 2021

Journal of Surgery and Medicine

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Background/Aim: Thiols are an important part of the antioxidant system which destroy reactive oxygen molecules, especially in inflammatory reactions. Maneuvers expressing the prostate fluid required for the diagnosis of chronic prostatitis are not practical and are rarely used in clinical practice. We aimed to compare the level of native thiol/disulphide as a supportive biomarker in patients with chronic abacterial prostatitis. Methods: Twenty patients diagnosed with chronic prostatitis and 20 healthy volunteers were included in this prospective-case control study. Both groups were compared in terms of native thiol disulphide homeostasis, IPSS, QoL and PSA levels. Results: In the chronic prostatitis group, the native thiol level was significantly lower (P=0.043), the % disulfide/natural thiol was higher (P=0.037), the international prostate symptom score was higher (P=0.006), the quality of life was higher (P=0.023) and the maximum flow rate was lower (P=0.009) compared to the healthy volunteers. Conclusion:In this study, we found that the native thiol (SH) level in patients with chronic prostatitis was low and their disulphide level was high; therefore, we think that the level of native thiol/total thiol may assist in supporting the diagnosis of chronic prostatitis.

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“…However, thiol levels can be influenced by a multitude of factors and are not diseasespecific. In addition, the studies discussed in this review have been performed in highly selected patients and control groups, without various comorbidities that influence systemic thiol levels [8,22]. This might overestimate the influence of thiols on the prognosis, as results are not generalizable to the general population of patients.…”

Section: Conclusion and General Discussionmentioning

confidence: 99%

“…Five studies reported on the thiol redox status in patients with prostate cancer [8,17,19,21,22]. All, but one [21], described significantly lower levels of total thiols in patients with prostate cancer compared to healthy controls, and three described lower native thiol levels [8,17,22], but only two studies also described lower disulfide levels [8,22]. Factors that were associated with lower thiol levels in prostate cancer constituted older age, lower educational level, current or previous smoking and a higher BMI [19].…”

Section: Prostate Cancermentioning

confidence: 99%