SCUBE1: a promising biomarker in renal cell cancer

Karagüzel, Ersagun; Menteşe, Ahmet; Kazaz, İlke Onur; Demir, Selim; Örem, Asım; Okatan, Ali Ertan; Altay, Diler Us; Yaman, Serap Özer

doi:10.1590/s1677-5538.ibju.2016.0316

Cited by 14 publications

(9 citation statements)

References 28 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cases et al (1991) showed that CEA, CA-50 and CA-125 levels were elevated in serum of patients with chronic renal failure and in haemodialysis patients ( 13 ). Karaguzel et al showed that signal peptide, CUB domain and EGF like domain containing 1 (SCUBE-1) appears to represent a promising bio-marker in the diagnosis and follow-up of cases of renal tumor ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

The diagnostic value of FNDC5/Irisin in renal Cell Cancer

et al. 2018

Self Cite

View full text Add to dashboard Cite

Purposes:The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer.Materials and Methods:In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected and serum FNDC5/Irisin and carcinoembryonic antigen (CEA) levels were determined using enzyme-linked immunosorbent assay (ELISA).Results:FNDC5/irisin and CEA levels in renal cancer patients were significantly higher compared with the control group (p=0.0001, p=0.009, respectively). Also, FNDC5 levels was more sensitive and specific than CEA levels. The best cut-off points for FNDC5/irisin were >105pg/mL and CEA were >2.67ng/mL for renal cancer.Conclusions:FNDC5/Irisin may be used as a diagnostic biomarker for renal cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

The diagnostic value of FNDC5/Irisin in renal Cell Cancer

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Signal peptide-CUB (complement C1r/ C1s, U egf, and Bmp1)-EGF (epidermal growth factor)-like domain-containing protein-1 (SCUBE-1) is a newly defined marker of platelet activation detected in thrombocyte and endothelial cells. Vascular endothelial cells play a significant role in pathophysiological processes such as cancer metastasis, angiogenesis inflammation, and vascular diseases [5,6]. It is shown that SCUBE-1 is stored in platelet α granules and to move to the cell surface during platelet activation [7,8].…”

Section: Introductionmentioning

confidence: 99%

Investigation of SCUBE-1 levels in pediatric patients with beta-thalassemia

Acıpayam¹,

Tuncel²,

Güneş³

et al. 2019

Journal of Surgery and Medicine

View full text Add to dashboard Cite

Aim: A thrombosis and inflammation marker, Signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domaincontaining protein 1 (SCUBE-1) is expressed in endothelial cells and activated platelets. We aimed to investigate the levels of this marker in patients with Thalassemia major (TM), a disease which causes a tendency to thrombosis. Methods: Twenty patients with TM and age and gender-matched twenty healthy controls were included in this prospective case-control study. Other thrombosis markers such as D-dimer and homocysteine were studied in addition to SCUBE-1 in both groups. Results: The SCUBE1 and D-dimer levels were higher in the TM group compared to the control group (P=0.004, P=0.023, respectively). A significant positive correlation was detected between platelet count and SCUBE1 (r=0.342, P=0.031). Conclusion: We detected elevated SCUBE1 levels in children with TM compared to the healthy controls, which correlated with platelet count. SCUBE1 may be used as a thrombosis marker in TM in the early stages of the disease.

show abstract

“…In acute coronary syndrome and acute ischemic stroke, the SCUBE‐1 plasma concentration was demonstrated to be elevated . Further, SCUBE levels were observed to be higher in various cancer patients (gastrointestinal and renal cell carcinoma) . All the above‐mentioned properties indicate that SCUBE can play an overall role in facilitating inflammatory angiogenesis, and its level has also been recorded to be related to malignity.…”

Section: Discussionmentioning

confidence: 95%

The relationship of serum SCUBE‐1, ‐2 and ‐3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients

Gunduz

Batmaz

Bozan³

et al. 2020

Int J of Rheum Dis

View full text Add to dashboard Cite

Aim:This study aimed to investigate the relationship between the level of serum signal peptide-CUB-EGF domain-containing protein (SCUBE)-1, SCUBE-2 and SCUBE-3 and clinical findings and ultrasonographic skin thickness in systemic sclerosis (SSc). Material and Methods: Thirty patients who met the American College ofRheumatology/European League against Rheumatism 2013 SSc classification criteria and 44 healthy volunteers who were compatible with the patient group in terms of age and gender were included in the study. Serum SCUBE levels were measured by enzyme-linked immunosorbent assay. Ultrasonographic skin thickness measurements were simultaneously performed.Results: No significant difference was found between the serum SCUBE levels of SSc patients and serum SCUBE levels of the control group. A negative correlation was detected between serum SCUBE-1 level and forced expiratory volume in 1 second (FEV 1 ). While a positive correlation was detected between serum SCUBE-2 level and the Duruöz Hand Index and serum C4 level, a negative correlation was determined with the forced vital capacity (FVC) value. A negative correlation was determined between serum SCUBE-3 level and echocardiographic pulmonary artery pressure (PAP). A correlation could not be determined between serum SCUBE levels and ultrasonographic skin thickness. However, a positive correlation was observed between ultrasonographic skin thickness and the modified Rodnan skin score. Conclusion:In this study, a correlation was observed between serum SCUBE levels and some clinical and laboratory parameters (FEV 1 , FVC, PAP, C4, and Duruöz Hand Index) in SSc patients. New clinical studies are needed to better understand the contribution of these molecules in the progression and pathogenesis of SSc. K E Y W O R D S SCUBE, skin thickness, systemic sclerosis, ultrasonography | 527 GÜNDÜZ et al. How to cite this article: Gündüz İ, Batmaz İ, Bozan T, Ekinci A, Cevik R. The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients. Int J Rheum Dis. 2020;23:526-531.

show abstract

SCUBE1: a promising biomarker in renal cell cancer

Cited by 14 publications

References 28 publications

The diagnostic value of FNDC5/Irisin in renal Cell Cancer

The diagnostic value of FNDC5/Irisin in renal Cell Cancer

Investigation of SCUBE-1 levels in pediatric patients with beta-thalassemia

The relationship of serum SCUBE‐1, ‐2 and ‐3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients

Contact Info

Product

Resources

About