The relationship of serum SCUBE‐1, ‐2 and ‐3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients

Gunduz, Ibrahim; Batmaz, İbrahim; Bozan, Turgut; Ekinci, Aysun; Çevik, Remzi

doi:10.1111/1756-185x.13798

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…SCUBE-1 has been studied in many diseases (13,14). With the studies carried out, more information was gathered about its properties and effectiveness (15).…”

Section: Discussionmentioning

confidence: 99%

Koroner Arter Bypass hastalarında Kan ve Perikardiyal Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Düzeyleri ve Ventrikül Fonksiyonları Arasındaki İlişki

Kankılıç¹,

Karahan²,

Demirtaş³

et al. 2021

Harran Üniversitesi Tıp Fakültesi Dergisi

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Background: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-like domain-containing protein 1(SCUBE-1) is a cell surface protein studied as a biomarker in thrombosis and ischemia conditions and secreted at currently studied early embryogenesis. The aim of this study is to investigate the relationship between left ventricular functions and pericardial / serum SCUBE-1 values of patients who underwent coronary artery bypass surgery. Materials and Methods: Forty patients who underwent cardiopulmonary bypass graft surgery were included in the study. Detailed echocardiographic findings of the patients were made before the operation. Left ventricular dysfunction markers were determined according to left ventricular fracshortening. SCUBE-1 levels were studied with ELISA kits in blood plasma and pericardial fluid samples. SCUBE-1 levels were statistically compared between the determined groups. Results: Statistical differences were observed in LVDs, IVSd, neutrophil, RBC, CK-MB, troponin-I and WBC values in low and high FS groups (p <0.05). SCUBE-1 plasma levels did not differ statistically between the FS groups (p> 0.05). The same situation was similar for pericardial fluid levels (p> 0.05). Correlation was seen between SCUBE-1 plasma levels and SCUBE-1 pericardial levels (p <0.05). There was no significant correlation between echocardiographic findings and SCUBE-1 levels (p> 0.05). Conclusions: These results showed us that SCUBE-1 plasma and the pericardial fluid levels had no effect on the left ventricular dysfunction. SCUBE-1 is not one of the currently identified markers of cardiac dysfunction. Future studies will further increase our knowledge on this subject.

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“…SCUBE-1 has been studied in many diseases (13,14). With the studies carried out, more information was gathered about its properties and effectiveness (15).…”

Section: Discussionmentioning

confidence: 99%

Koroner Arter Bypass hastalarında Kan ve Perikardiyal Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Düzeyleri ve Ventrikül Fonksiyonları Arasındaki İlişki

Kankılıç¹,

Karahan²,

Demirtaş³

et al. 2021

Harran Üniversitesi Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

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The biology of SCUBE

et al. 2023

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The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins in vertebrates, SCUBE1, 2 and 3, which are highly conserved in zebrafish, mice and humans. Each SCUBE gene encodes a polypeptide of approximately 1000 amino acids that is organized into five modular domains: (1) an N-terminal signal peptide sequence, (2) nine tandem epidermal growth factor (EGF)-like repeats, (3) a large spacer region, (4) three cysteine-rich (CR) motifs, and (5) a CUB domain at the C-terminus. Murine Scube genes are expressed individually or in combination during the development of various tissues, including those in the central nervous system and the axial skeleton. The cDNAs of human SCUBE orthologs were originally cloned from vascular endothelial cells, but SCUBE expression has also been found in platelets, mammary ductal epithelium and osteoblasts. Both soluble and membrane-associated SCUBEs have been shown to play important roles in physiology and pathology. For instance, upregulation of SCUBEs has been reported in acute myeloid leukemia, breast cancer and lung cancer. In addition, soluble SCUBE1 is released from activated platelets and can be used as a clinical biomarker for acute coronary syndrome and ischemic stroke. Soluble SCUBE2 enhances distal signaling by facilitating the secretion of dual-lipidated hedgehog from nearby ligand-producing cells in a paracrine manner. Interestingly, the spacer regions and CR motifs can increase or enable SCUBE binding to cell surfaces via electrostatic or glycan-lectin interactions. As such, membrane-associated SCUBEs can function as coreceptors that enhance the signaling activity of various serine/threonine kinase or tyrosine kinase receptors. For example, membrane-associated SCUBE3 functions as a coreceptor that promotes signaling in bone morphogenesis. In humans, SCUBE3 mutations are linked to abnormalities in growth and differentiation of both bones and teeth. In addition to studies on human SCUBE function, experimental results from genetically modified mouse models have yielded important insights in the field of systems biology. In this review, we highlight novel molecular discoveries and critical directions for future research on SCUBE proteins in the context of cancer, skeletal disease and cardiovascular disease.

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Assessment of the Levels Of Some Prognostic Biomolecules (Galectins, ACE2, SCUBE1/2/3) in COVID-19 Patients

Karamese,

Gumus,

Atalay

et al. 2023

Future Microbiol.

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Aim: Our aim was to investigate the differences between healthy people and COVID-19 patients in terms of some immunological biomolecules, especially including those related to the inflammation process. Materials & methods: A total of 180 participants (90 healthy controls and 90 COVID-19 patients) were included. The expression levels of eight different inflammation-related biomolecules were measured by the ELISA technique. Results: The mean levels of ACE2, ANG1–7, GAL3, GAL9, SCUBE1, SCUBE2 and SCUBE3 were elevated in COVID-19 patients when compared with healthy controls, while the mean level of GAL2 was lower in COVID-19 patients than controls. Conclusion: To understand the cytokine storm mechanism and related parameters, more detailed studies should be performed investigating more related biomolecules and related signaling pathways.

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The relationship of serum SCUBE‐1, ‐2 and ‐3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients

Cited by 3 publications

References 20 publications

Koroner Arter Bypass hastalarında Kan ve Perikardiyal Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Düzeyleri ve Ventrikül Fonksiyonları Arasındaki İlişki

Koroner Arter Bypass hastalarında Kan ve Perikardiyal Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Düzeyleri ve Ventrikül Fonksiyonları Arasındaki İlişki

The biology of SCUBE

Assessment of the Levels Of Some Prognostic Biomolecules (Galectins, ACE2, SCUBE1/2/3) in COVID-19 Patients

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