Research prioritization of men’s health and urologic diseases

Abstract

Objectives We sought to determine whether disease representation in the Cochrane Database of Systematic Reviews (CDSR) reflects disease burden, measured by the Global Burden of Disease (GBD) Study as disability-adjusted life-years (DALYs).Materials and Methods Two investigators performed independent assessment of ten men’s health and urologic diseases (MHUDs) in CDSR for systematic review and protocol representation, which were compared with percentage of total 2010 DALYs for the ten conditions. Data were analyzed for correlation using Spearman rank analysis.Results Nine of ten MHUDs were represented by at least one CDSR review. There was a poor and statistically insignificant positive correlation between CDSR representation and disease burden (rho = 0.42, p = 0.23). CDSR representation was aligned with disease burden for three conditions, greater than disease burden for one condition, and less than disease burden for six conditions.Conclusions These results yield high-quality estimates to inform future research prioritization for MHUDs. While prioritization processes are complex and multi-faceted, disease burden should be strongly considered. Awareness of research priority setting has the potential to minimize research disparities on a global scale.

The Importance of Reporting Clinical and Epidemiological Data in Urology: Local Experiences and Insights from the International Literature

“…Pathologies of the genito-urinary tract are responsible for a considerable disease burden worldwide, leading to significant losses of income, lost working days, increased expenditures for national healthcare systems, and decreased quality of life (QoL) in the affected patients [1]. Among these diseases, infections and malignancies in this anatomical region are some of the most important illnesses in human medicine; nevertheless, benign prostate hyperplasia (BPH), erectile dysfunction, hypospadias, urinary incontinence, and vesicoureteral reflux are also relevant disorders affecting millions [2]. Before the 2000s, systematic data collection on the epidemiology of urological ailments was lacking.…”

What do we know about evidence-informed priority setting processes to set population-level health-research agendas: an overview of reviews

“…not a critical or systematic review; Core concept does not evaluate research priority setting exercises Knight et al ( 2014 ) Core concept does not evaluate research priority setting exercises Johnston et al ( 2016 ) Ineligible study design, i.e. not a critical or systematic review; Core concept does not evaluate research priority setting exercises Jones and Geneau ( 2012 ) Core concept does not evaluate research priority setting exercises Karimkhani et al ( 2016 ) Core concept does not evaluate research priority setting exercises Kong et al ( 2019 ) Core concept does not evaluate research priority setting exercises Kühne et al ( 2021 ) Core concept does not evaluate research priority setting exercises Morton et al ( 2012 ) Core concept does not evaluate research priority setting exercises Nicolau et al ( 2012 ) Core concept does not evaluate research priority setting exercises Okland et al ( 2017 ) Core concept does not evaluate research priority setting exercises Oncology Nursing Forum ( 2019 ) Ineligible study design, i.e. not a critical or systematic review Pozzar and Berry ( 2017 ) Core concept does not evaluate research priority setting exercises Pratt ( 2020 ) Ineligible study design, i.e.…”

Quick prioritization of Cochrane reviews on benign conditions of the prostate

“…Health topic and intended beneficiaries : Due to the broad scope of the Group's review portfolio and limited resources for conducting prioritization activities, the first part of this project focused on men with benign conditions of the prostate, including prostatitis and lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). Previous research has highlighted that the number of Cochrane reviews underrepresented the burden of these conditions [11].…”