Abstract:Pathologies of the genito-urinary tract are responsible for a considerable disease burden worldwide, leading to significant losses of income, lost working days, increased expenditures for national healthcare systems, and decreased quality of life (QoL) in the affected patients. Among these diseases, infections and malignancies in this anatomical region are some of the most important illnesses in human medicine; nevertheless, benign prostate hyperplasia (BPH), erectile dysfunction, hypospadias, urinary incontin… Show more
“…We found that Escherichia coli was the most prevalent pathogen in both sexes regarding isolated pathogens, which is in line with previous reports [ 1 , 7 , 26 , 28 , 33 , 34 , 35 ]. However, the risk of IHM was associated with Staphylococcus aureus , but the risk decreased with other isolated pathogens, which is also observed among patients with COPD and type 2 diabetes mellitus [ 7 , 27 ].…”
Section: Discussionsupporting
confidence: 93%
“…Urinary tract infections (UTIs) are considered the third most common type of infections [ 1 , 2 ]. UTI incidence increases with age and is an important cause of antibiotic use, morbidity, and mortality in older adults [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…The diagnosis of a UTI may be complicated among old patients [ 1 ] as classical symptoms and signs are frequently replaced by atypical symptoms, such as asymptomatic bacteriuria [ 6 ]. For example, bacteremia due to UTI in older patients may manifest as delirium instead of fever and chills [ 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, UTIs result in a huge economic burdens to healthcare systems, leading to significant losses of income, morbidity, and restricted activity [ 1 , 3 , 5 , 10 , 15 , 16 , 17 ]. UTIs are responsible for one million emergency room visits in the USA and 100,000 hospitalizations each year [ 8 ].…”
(1) Background: To assess time trends in the incidence and in-hospital outcomes of urinary tract infection (UTI) in older people (≥65 years) in Spain (2001–2018) according to sex and to identify the factors independently associated with in-hospital mortality (IHM). (2) Methods: Using the Spanish National Hospital Database, we analyzed comorbidity, procedures, diagnosis, isolated microorganisms, and outcomes. (3) Results: We included 583,693 admissions (56.76% women). In both sexes, the incidence increased with age over time (p < 0.001). In men and women, the highest IHM was found among the oldest patients (>84 years) with values of 9.16% and 8.6%, respectively. The prevalence of bacteremia increased from 4.61% to 4.98% from 2001 to 2018 (p < 0.001) and sepsis decreased from 3.16% to 1.69% (p < 0.001). The risk of dying increased with age (>84 years) (OR 3.63; 95% CI 3.5–3.78) and with almost all comorbidities. Urinary catheter was a risk factor for women (OR 1.1; 95% CI 1.02–1.18) and protective for men (OR 0.71; 95% CI 0.66–0.76). Isolation of Staphylococcus aureus increased the risk of IHM by 40% among men (OR 1.4; 95% CI 1.28–1.53). After adjusting for confounders, IHM decreased over time. (4) Conclusions: The incidence of UTIs was higher in older patients and increased over time; however, IHM decreased during the same period. Female sex, age, comorbidities, sepsis, and a Staphylococcus aureus isolation increased risk of IHM.
“…We found that Escherichia coli was the most prevalent pathogen in both sexes regarding isolated pathogens, which is in line with previous reports [ 1 , 7 , 26 , 28 , 33 , 34 , 35 ]. However, the risk of IHM was associated with Staphylococcus aureus , but the risk decreased with other isolated pathogens, which is also observed among patients with COPD and type 2 diabetes mellitus [ 7 , 27 ].…”
Section: Discussionsupporting
confidence: 93%
“…Urinary tract infections (UTIs) are considered the third most common type of infections [ 1 , 2 ]. UTI incidence increases with age and is an important cause of antibiotic use, morbidity, and mortality in older adults [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…The diagnosis of a UTI may be complicated among old patients [ 1 ] as classical symptoms and signs are frequently replaced by atypical symptoms, such as asymptomatic bacteriuria [ 6 ]. For example, bacteremia due to UTI in older patients may manifest as delirium instead of fever and chills [ 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, UTIs result in a huge economic burdens to healthcare systems, leading to significant losses of income, morbidity, and restricted activity [ 1 , 3 , 5 , 10 , 15 , 16 , 17 ]. UTIs are responsible for one million emergency room visits in the USA and 100,000 hospitalizations each year [ 8 ].…”
(1) Background: To assess time trends in the incidence and in-hospital outcomes of urinary tract infection (UTI) in older people (≥65 years) in Spain (2001–2018) according to sex and to identify the factors independently associated with in-hospital mortality (IHM). (2) Methods: Using the Spanish National Hospital Database, we analyzed comorbidity, procedures, diagnosis, isolated microorganisms, and outcomes. (3) Results: We included 583,693 admissions (56.76% women). In both sexes, the incidence increased with age over time (p < 0.001). In men and women, the highest IHM was found among the oldest patients (>84 years) with values of 9.16% and 8.6%, respectively. The prevalence of bacteremia increased from 4.61% to 4.98% from 2001 to 2018 (p < 0.001) and sepsis decreased from 3.16% to 1.69% (p < 0.001). The risk of dying increased with age (>84 years) (OR 3.63; 95% CI 3.5–3.78) and with almost all comorbidities. Urinary catheter was a risk factor for women (OR 1.1; 95% CI 1.02–1.18) and protective for men (OR 0.71; 95% CI 0.66–0.76). Isolation of Staphylococcus aureus increased the risk of IHM by 40% among men (OR 1.4; 95% CI 1.28–1.53). After adjusting for confounders, IHM decreased over time. (4) Conclusions: The incidence of UTIs was higher in older patients and increased over time; however, IHM decreased during the same period. Female sex, age, comorbidities, sepsis, and a Staphylococcus aureus isolation increased risk of IHM.
“…9 Reporting of epidemiological data in urology and urinary tract infections are crucial to influence the development of therapeutic guidelines for UTIs and also the relevant stakeholders and government representatives often base their decisions on published evidence. 10 According to the Center for Disease Control and Prevention (CDC), UTIs are the most common bacterial infection requiring medical care, resulting in 8.6 million ambulatory care visits in 2007, 23% of which occurred in the emergency department. 11 An estimated 50% of women report having had a UTI at some point in their lives and 8.3 million office visits and more than 1 million hospitalizations, for an overall annual cost of more than $1 billion.…”
Background: Urinary tract infection (UTI) is a common health problem occurring when infectious agents colonize, invade, and propagate the urinary tract including the urethra, bladder, renal pelvis, or renal parenchyma. The study aimed to determine the prevalence of symptomatic UTI, drug resistance pattern, and its associated factors among patients attending adult outpatient department (OPD) at Hawassa University Comprehensive Specialized Hospital (HUCSH). Methods: A cross-sectional study was conducted from October 2018 to February 2019 among adults ≥18 years old with symptoms of UTI. Processing of specimens for culture and identification was done. Antimicrobial susceptibility was done for positive urine cultures. Data entry and analysis were performed using SPSS version 23.0 software. Bivariate and multivariate logistic regression analysis test results were used. Results: The overall prevalence of symptomatic urinary tract infection was 32.8% (95% CI: 28.3-37.6). The predominant isolated bacteria was E. coli 46 (36.2%) followed by S. aureus 21 (16.5%). Gram-negative bacteria were a high level of resistance to ampicillin (71.4%), and tetracycline (68.2%). Gram-positive bacteria were highly resistant to norfloxacin (77.7%). The overall prevalence of multi-drug resistant isolates was 102 (80.3%). Being female, no formal education, and self-medication history had more likely cause UTI. Conclusion: Urinary tract infection (UTI) among adults was prevalent in the study area. Being female, educational status and self-medication history had a significant association with UTI. Resistance to ampicillin, tetracycline, and norfloxacin was high. Therefore, culture and antibiotic susceptibility testing should be routinely used for the proper management of patients with UTI.
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