ECLAMC Study: prevalence patterns of hypospadias in South America: multi-national analysis over a 24-year period

Fernández, Nicolás; Pérez, Jaime; Monterrey-Gutiérrez, Pedro; Poletta, Fernando A.; Bägli, Darius; Lorenzo, Armando J.; Zarante, Ignacio

doi:10.1590/s1677-5538.ibju.2016.0002

Cited by 16 publications

(12 citation statements)

References 18 publications

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“…As the birth prevalence of hypospadias increases across the world [4,5,6,7,8,9,10], research into the association between pollutant exposure and hypospadias has defined a critical exposure period as the early first trimester of pregnancy [11]. Pollutants which interfere with MET during genitourinary development or hormonal cascades may play a role in hypospadias etiology.…”

Section: Introductionmentioning

confidence: 99%

Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants

White

Kovar

Chambers

et al. 2019

IJERPH

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Objective: Investigate whether residential prenatal exposure to heavy metal hazardous air pollutants (HMHAPs) is associated with an increased risk of hypospadias. Methods: Data on non-syndromic hypospadias cases (n = 8981) and control patients delivered in Texas were obtained from the Texas Birth Defects Registry and matched 1:10 by birth year. Average exposure concentrations of HMHAPs were obtained from the 2005 U.S. Environmental Protection Agency National-Scale Air Toxics Assessment and categorized into quintiles. Odds ratios and 95% confidence intervals were estimated. STROBE reporting guidelines were followed. Results: We observed associations between hypospadias and prenatal HMHAP exposure. Manganese demonstrated significant increased risk of hypospadias at the medium, medium-high and high exposure quintiles; lead in the medium-high and high exposure quintiles. Cadmium, mercury and nickel demonstrated a significant inverted “U-shaped” association for exposures with significant associations in the medium and medium-high quintiles but not in the medium-low and high quintiles. Arsenic and chromium demonstrated a significant bivalent association for risk of hypospadias in a lower quintile as well as a higher quintile with non-significant intermediate quintiles. Conclusions: Using data from one of the world’s largest active surveillance birth defects registries, we identified significant associations between hypospadias and HMHAP exposures. These results should be used in counseling for maternal demographic risk factors as well as avoidance of heavy metals and their sources.

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Section: Introductionmentioning

confidence: 99%

Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants

White

Kovar

Chambers

et al. 2019

IJERPH

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“…The Colombian programs have reviewed the descriptive epidemiology of congenital heart defects (Tassinari et al 2018), hypospadias (Fernández et al 2017;Baltaxe and Zarante 2006), and BD in general (Zarante et al 2010). The Bogotá program described the sonographic detection of congenital heart defects has been described in the city of Bogotá (García et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Birth defects surveillance: experiences in Argentina and Colombia

Groisman¹,

Liascovich²,

Bidondo³

et al. 2019

J Community Genet

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Birth defects (BDs) are structural or functional anomalies, sporadic or hereditary, of prenatal origin. Public health surveillance is defined as the ongoing systematic collection, analysis, and interpretation of outcome-specific data for use in the planning, implementation, and evaluation of public health practice. BD surveillance systems may have different characteristics according to design, coverage, type of surveillance, case ascertainment, case definition, BD description, maximum age of diagnosis, pregnancy outcomes, coding systems, and the location of the coding process (central or local). The aim of this article is to describe and compare methodology, applications, and results of birth defect surveillance systems in two South-American countries: Colombia and Argentina. In both countries, the surveillance systems developed activities in relation to the Zika virus emergency. For most BDs, a statistically significant higher prevalence is observed in Argentina-RENAC than in Colombian registries. This may be due to methodological reasons or real differences in prevalence. The strengths, weaknesses, and the future perspectives of the Argentine and Colombian systems are presented. When developing a surveillance system, the objectives, the available resources, and previous experiences in similar contexts must be taken into account. In that sense, the experience of Argentina and Colombia can be useful for others when developing a birth defect surveillance system.

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“…En 2017, el equipo de Zarante publicó un análisis de los patrones de prevalencia de hipospadias en Sudamérica, y mostró una prevalencia de 1,13 de cada 1000 partos y un incremento total del 3,3% a lo largo de las últimas dos décadas (45). Paulozzi informa que la primera y segunda anomalía congénita más frecuente en Estados Unidos en el recién nacido varón sería la criptorquidia y la hipospadias, respectivamente (46).…”

Section: Causas Del Escaso Desarrollo Del Estudio De Las Anomalías Geunclassified

Anomalías genitales: contextualización de un campo olvidado en el diagnóstico prenatal

Soto¹

2020

Rev. Colomb. Obstet. Ginecol.

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Objetivo: hacer una reflexión sobre el bajo desarrollo que hay actualmente en el campo del diagnóstico prenatal de las anomalías genitales. Materiales y métodos: a partir de la tesis de que el desarrollo del diagnóstico antenatal de las anomalías genitales es escaso, se presenta una comparación con el estado actual de otros campos del diagnóstico prenatal, así como con su contrapartida posnatal; se analizan las distintas causas que pueden haber llevado a esta situación, y se reflexiona sobre formas de mejora de la especialidad. Conclusión: en comparación con otras áreas del diagnóstico prenatal, la detección de anomalías genitales tiene un menor nivel de desarrollo en cuanto a la disponibilidad de herramientas diagnósticas, de protocolos de manejo o investigación clínica. Algunas causas probables son una impresión de baja prevalencia, una importancia limitada o las dificultades para su exploración. Una forma de reforzar este componente de la medicina fetal sería la integración del conocimiento actual, la adquisición de herramientas adecuadas, y una traslación a la medicina clínica.

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ECLAMC Study: prevalence patterns of hypospadias in South America: multi-national analysis over a 24-year period

Cited by 16 publications

References 18 publications

Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants

Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants

Birth defects surveillance: experiences in Argentina and Colombia

Anomalías genitales: contextualización de un campo olvidado en el diagnóstico prenatal

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