Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey

Üçer, Oktay; Yücetaş, Uğur; Çelen, İlker Hüseyin; Toktaş, Gökhan; Müezzinoğlu, Talha

doi:10.1590/s1677-5538.ibju.2014.0462

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…According to the data of Chinese researchers, the PSA-AV scores performed well with prostate specific antigen density (PSAD) and were better than PSA alone in predicting PCa, suggesting that PSA-AV scores could be useful for predicting PCa in Chinese population, especially among younger patients and patients with small prostates [4]. Several Turkish researchers confirmed that PSA-AV cut-off of 700 could be used for predicting positive prostate biopsy findings in patients under the age of 60, and in those with low prostate volumes [35].…”

Section: Resultsmentioning

confidence: 99%

Epidemiological and Economic Evaluation of a Pilot Prostate Cancer Screening Program

et al. 2020

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Background. Prostate cancer (PCa) is the second most commonly diagnosed cancer, and the sixth most common killer among men worldwide (Aubry et al., 2013). This research was motivated by the fact that PCa screening continues to be a controversial topic in the Kazakh medical community. This study aimed at description of how newly diagnosed PCa patients are managed in Pavlodar region of the Kazakhstan Republic and at presentation of a budget impact analysis (BIA) for PCa screening program. Also, we aimed to provide a comparative analysis of pricing system on medical services applied in both private and public healthcare sectors of the Kazakhstan Republic. Methods. New cases of PCa have been retrospectively analyzed for the period from January 2013 to December 2017 based on the information obtained from information system “Policlinic” maintained by the Pavlodar regional branch of the Republican Center for Electronic Health and from Cancer Registry of Pavlodar Regional Oncology Center. All data were analyzed with the help of SPSS 20.0 software. Results. The mean age of PCa patients was 68.34 years (SD = 8.559). The government of Kazakhstan invested 20,437,000 KZT (Kazakhstani tenge) in 2017 equivalently 61,188 USD—to fund a pilot study for examination of 9638 men. From 2013 to 2017, out of 49,334 men residing in Pavlodar region of Kazakhstan 1,248 men were diagnosed with prostate diseases, including 130 PCa cases. The PCa detection rate was equal to two cases per month. Only 22.8% of all PCa cases identified in the region within specified time period were revealed as a result of the government-funded PCa screening program. The average prostate cancer detection rate among the target group of Pavlodar region within the period of 5 years was equal to 0.23%. Conclusion. Based on the fact that the PCa screening program failed to enable adequate detection of new PCa cases, we would not recommend to continue this type of screening unless it is undergone careful revision and replanning.

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Section: Resultsmentioning

confidence: 99%

Epidemiological and Economic Evaluation of a Pilot Prostate Cancer Screening Program

et al. 2020

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“…Patel et al [35] proposed the PSA-AV score by combining the three clinical indexes of age, PV, and PSA for the first time. A study conducted in Turkey revealed no superiority of PSA-AV score in patients with PV values of 20-60 cm 3 [36]. However, Chinese scholars further studied the clinical significance of PSA-AV score in the Chinese population, and found that T A B L E 5.…”

Section: Discussionmentioning

confidence: 95%

The diagnostic value of a new formula combining age and prostate volume in prostate cancer

Yang¹,

Shan²,

Qiang³

et al. 2021

J. Mens. Health

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Background and objective: This study combined two clinical indicators (age and prostate volume (PV)) to generate age to PV (AVR) ratio, whose diagnostic value for prostate cancer (PCa) was examined based on prostate speciﬁc antigen (PSA) in the range of 4--20.0 ng/mL. Methods: The medical records of patients who underwent transrectal ultrasound-guided biopsy of the prostate in our hospital from June 2015 to June 2019 were examined retrospectively. According to the pathological results of the biopsy, the patients were divided into the PCa and benign prostatic hyperplasia (BPH) groups. Receiver operating characteristic (ROC) curves for TPSA, PSAD, PV, (F/T)PSA, AVR, and PSA-AV were plotted with SPSS 26.0 and GraphPad Prism 5.0, and areas under the ROC curves (AUROCs) were determined and compared by Delong test. A log-linear model was used to compare AVR and other parameters with similar high sensitivities, for speciﬁcity. Results: The AUROC for AVR was signiﬁcantly different from those of TPSA (p < 0.001), PV (p = 0.004),(F/T)PSA (p < 0.001), and PSA-AV (p = 0.006), and similar to that of PSAD (p = 0.064). With the same high sensitivity (90.0%), log-linear model analysis showed that the speciﬁcity of AVR was signiﬁcantly higher than those of TPSA and (F/T)PSA (p < 0.01), while there were no signiﬁcant differences among AVR and PSAD, PV and PSA-AV. Conclusion: With PSA in the range of 4--20.0 ng/mL, AVR may be useful in sparing an invasive intervention for a number of patients.

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“…In addition, PSA is organic but not disease specific and does not have sufficient sensitivity. Inflammation, trauma or benign proliferation may also change the serum PSA levels …”

Section: Discussionmentioning

confidence: 99%

Morphine contributed to the deterioration of cancer via miR-543/MARCKS/FcγR-mediated phagocytosis pathway

Luo

Chen

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives It has been confirmed that morphine was detrimental to patients with cancers. Hence, we aimed to reveal a certain mechanism of morphine in cancer development. Methods Microarray and GSEA analysis were utilized to seek for differently expressed genes and pathway. Key findings Bioinformatics analysis identified that downregulation of MARCKS and upregulation of miR‐543 in samples treated with morphine. FcγR‐mediated phagocytosis pathway was illustrated to be upregulated in the control. PANC‐1 and DU145 cell viability was increased but apoptosis was declined as morphine concentration went up from 10−8 to 10−6 mol/l. On the other curve, the viability was reduced and apoptosis was elevated from 10−6 to 10−5 mol/l. The expression of miR‐543 ran the same trend as cell viability. Assays in vivo and in vitro validated that miR‐543 facilitated cell viability, tumour growth, levels of CA199 and PSA, whereas inhibited apoptosis. MARCKS could target and inhibit miR‐543 expression, which exhibited an opposite effect on cancer progression. MiR‐543 blocked but MARCKS activated FcγR‐mediated phagocytosis pathway. Conclusions Morphine at 10−6 mol/l could benefit miR‐543 expression to inhibit MARCKS expression, consequently, blocking FcγR‐mediated phagocytosis pathway, which contributed to the cancer progression in vitro and in vivo.

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Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey

Cited by 7 publications

References 12 publications

Epidemiological and Economic Evaluation of a Pilot Prostate Cancer Screening Program

Epidemiological and Economic Evaluation of a Pilot Prostate Cancer Screening Program

The diagnostic value of a new formula combining age and prostate volume in prostate cancer

Morphine contributed to the deterioration of cancer via miR-543/MARCKS/FcγR-mediated phagocytosis pathway

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