Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination

Esteves, Sandro C.

doi:10.1590/s1677-5538.ibju.2014.04.02

Cited by 145 publications

(120 citation statements)

References 55 publications

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“…This is due, in part, to the fact that conventional semen analysis does not assess the diverse array of biological properties that spermatozoa express as eminent specialized cells, or account for putative sperm dysfunctions that can be assessed by sperm DNA damage or seminal oxidative stress tests [Duran et al 2002;Esteves, 2014;Papillon-Smith et al 2015].…”

Section: Semen Analysismentioning

confidence: 99%

Oxidation-reduction potential of semen: what is its role in the treatment of male infertility?

Agarwal

Roychoudhury

Bjugstad³

et al. 2016

Therapeutic Advances in Urology

135

118

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The diagnosis of male infertility relies largely on conventional semen analysis, and its interpretation has a profound influence on subsequent management of patients. Despite poor correlation between conventional semen parameters and male fertility potential, inclusion of advanced semen quality tests to routine male infertility workup algorithms has not been widely accepted. Oxidative stress is one of the major mediators in various etiologies of male infertility; it has deleterious effects on spermatozoa, including DNA damage. Alleviation of oxidative stress constitutes a potential treatment strategy for male infertility. Measurement of seminal oxidative stress is of crucial role in the identification and monitoring of patients who may benefit from treatments. Various tests including reactive oxygen species (ROS) assay, total antioxidant capacity (TAC) assay or malondialdehyde (MDA) assay used by different laboratories have their own drawbacks. Oxidation-reduction potential (ORP) is a measure of overall balance between oxidants and antioxidants, providing a comprehensive measure of oxidative stress. The MiOXSYS™ System is a novel technology based on a galvanostatic measure of electrons; it presents static ORP (sORP) measures with static referring to the passive or current state of activity between oxidants and antioxidants. Preliminary studies have correlated sORP to poor semen qualities. It is potentially useful in prognostication of assisted reproductive techniques outcomes, screening of antioxidants either in vivo or during IVF cycles, identification of infertile men who may benefit from treatment of oxidative stress, and monitoring of treatment success. The simplified laboratory test requiring a small amount of semen would facilitate clinical application and research in the field. In this paper, we discuss the measurement of ORP by the MiOXSYS System as a real-time assessment of seminal oxidative stress, and argue that it is a potential valuable clinical test that should be incorporated into the male infertility workup and become an important guide to the treatment of oxidative stress-induced male infertility.

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Section: Semen Analysismentioning

confidence: 99%

Oxidation-reduction potential of semen: what is its role in the treatment of male infertility?

Agarwal

Roychoudhury

Bjugstad³

et al. 2016

Therapeutic Advances in Urology

135

118

View full text Add to dashboard Cite

show abstract

“…We have also contemplated our own data involving 982 men seeking evaluation for infertility that had subnormal semen analysis results based on the 1999 WHO criteria. We found that approximately 39 % of these men would be reclassified as 'normal' by the new 2010 criteria [20]. The adoption of the most recent WHO reference values will likely result in more men classified as having a 'normal' semen analysis.…”

Section: Discussionmentioning

confidence: 84%

“…The aforementioned WHO reference values, however, differ substantially because reference values of the 2010 manual are markedly lower than those of the 1999 version. These differences pose a problem because the classification of patients with 'normal' and 'abnormal' semen analysis will depend on the version of the WHO manual [19,20]. In a recent study, up to 15 % of men with at least one parameter below the 1999 WHO reference values were reclassified as 'normal' because all parameters were at or above the 2010 WHO thresholds [21].…”

Section: Discussionmentioning

confidence: 99%

A systematic review of recent clinical practice guidelines and best practice statements for the evaluation of the infertile male

Esteves¹,

Chan

2015

Int Urol Nephrol

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While the various panels of experts who contributed to the development of the CPG and BPS reviewed should be commended on their tremendous efforts aiming to establish a clinical standard in both the evaluation and management of male infertility, we recognized inconsistencies in the methodology of their synthesis and in the contents of their final recommendations. These discrepancies pose a barrier in the general implementation of these guidelines and may limit their utility in standardizing clinical practice or improving health-related outcomes. Continuous efforts are needed to generate high-quality evidence to allow further development of these important guidelines for the evaluation and management of males suffering from infertility.

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“…Нормативные показатели эякулята, предложенные в последнем издании Руководства Всемирной органи-зации здравоохранения (ВОЗ) по оценке и анализу эякулята (5-е издание (2010)) [2], вызвали полемику среди специалистов в области андрологии, спермато-логии и репродукции человека. Многие врачи-уроло-ги считают, что в связи с недостаточной строгостью предложенных критериев нарушения репродуктивной системы мужчин будут недооценены [3][4][5]. В послед-нем издании Руководства ВОЗ [2] использованы дан-ные из спермограмм мужчин, беременность у партнерш которых наступала в течение 12 мес половой жизни без предохранения.…”

Section: Introductionunclassified

Types of Pathozoospermia in Men With Infertility in Marriage Аnd/or Disorders of Reproductive System

Андреева¹,

Khayat²,

Сорокина³

et al. 2017

Androl. genit. hir.

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Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination

Abstract: ARTICLE INFO

Cited by 145 publications

References 55 publications

Oxidation-reduction potential of semen: what is its role in the treatment of male infertility?

Oxidation-reduction potential of semen: what is its role in the treatment of male infertility?

A systematic review of recent clinical practice guidelines and best practice statements for the evaluation of the infertile male

Types of Pathozoospermia in Men With Infertility in Marriage Аnd/or Disorders of Reproductive System

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