A systematic review of recent clinical practice guidelines and best practice statements for the evaluation of the infertile male

Esteves, Sandro C.; Chan, Peter

doi:10.1007/s11255-015-1059-0

Cited by 58 publications

(50 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Infertility is one of the most serious medical and sociodemographic problems worldwide. Approximately 30-40% of infertility cases are caused by male factors (Buzadzic et al, 2015;Esteves et al, 2015). Dramatic increase in male infertility over the last decades has been observed.…”

Section: Introductionmentioning

confidence: 99%

Glutathione s-transferase as a marker of oxidative stress in human ejaculated spermatozoa from patients with pathospermia

Vorobets

Фафула

Besedina

et al. 2018

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

It is believed that the most common causes of male infertility are impairment of spermatogenesis and sperm functions. Glutathione S-transferases (EC 2.5.1.18) play an important role in sperm physiology, specifically in antioxidant protection against oxidative damage. The catalase decomposition of lipid hydro-peroxides forms as a result of oxidative stress. We used a model of superoxide anion-generating system Fe3+/ascorbate or H2O2-induced stress to study the activity of glutathione s transferase in human ejaculated spermatozoa from patients with pathospermia and products of lipid peroxidation (TBARS) as a marker of oxidative stress. In the present study, dose dependent increase in the level of lipid peroxidation was observed for treatment with Fe3+/ascorbate or H2O2. The TBARS level was higher for sperm cells incubated with superoxide anion-generating system Fe3+/ascorbate than for H2O2. GSTs activity increased in spermatozoa treated with increasing concentration of superoxide anion-generating system Fe3+/ascorbate and H2O. We found that both Fe3+/ascorbate and H2O2 displayed similar inhibitory effects on sperm GSTs activity, however H2O2 at low concentrations activated enzyme activity only in normozoospermic samples, which can be explained as a defence response to oxidative stress. The time course of incubation with 100 μM H2O2 showed a sharp decrease in the enzyme activity during the first 5 min of incubation for both normozoospermic and pathozoospermic men. Preincubation of spermatozoa with GSH completely prevented the ROS-induced inhibition on GSTs only in normozoospermic samples. On the other hand, in pathospermic samples protectory effect of GSH was observed only against non-radical (H2O) radical, but not against radical (superoxide anion-generating system Fe3+/ascorbate) species. The results of our study showed higher oxygen-free radical production, evidenced by increased TBARS level in spermatozoa obtained from infertile men than normozoospermic men. The inhibitory effect of the radical (superoxide anion-generating system Fe3+/ascorbate) species on sperm GSTs activity and products of lipid peroxidation in sperm cells of fertile and infertile men were more expressed compared to non-radical (H2O) species. Our results indicate that estimation of sperm GSTs enzyme assays can be used as a bioindicator for impaired male fertility. The obtained results argue for a biological role of sperm GSTs in susceptibility of spermatozoa to oxidative damage and maintaining sperm antioxidant status.

show abstract

Section: Introductionmentioning

confidence: 99%

Glutathione s-transferase as a marker of oxidative stress in human ejaculated spermatozoa from patients with pathospermia

Vorobets

Фафула

Besedina

et al. 2018

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

show abstract

“…Geographical variation in the uptake and availability of investigations is likely, owing to the affordability of these tests. Moreover, practice guidelines vary, as shown by recommendations on PCOS and systematic reviews of diagnostic evaluation of male infertility and of endometriosis [65][66][67] .…”

Section: [H1] Epidemiologymentioning

confidence: 99%

Female subfertility

2019

Nat Rev Dis Primers

View full text Add to dashboard Cite

Subfertility is common, and affects one in six couples, half of whom lack an explanation for their delay in conceiving. Developments in the diagnosis and treatment of subfertility over the past 50 years have been truly remarkable. Indeed, current generations of couples with subfertility are more fortunate than previous generations as they have many more opportunities to become parents. The timely access to effective treatment for subfertility is important, as many couples have a narrow window of opportunity before the age-related effects of subfertility limit the likelihood of success. Assisted reproduction can overcome the barriers to fertility caused by tubal disease and low sperm counts, but little progress has been made in reducing the effect of increasing age on ovarian function. The next 5-10 years will likely see further increases in birth rates in women with subfertility, greater awareness of lifestyle factors and possible refinement of current assisted reproduction techniques and development of new ones. Such progress will bring challenging questions regarding the potential benefits and harms of treatments involving germ-cell manipulation, artificial gametes, genetic screening of embryos, and gene editing of embryos. We hope to see a major increase in fertility awareness, access to safe and cost-effective fertility care in low-income countries, and a reduction in the current disparity of access to fertility care.

show abstract

“…The expressions of pinopodes, estrogen receptor, progesterone receptor, cytokines related to embryo implantation integrin family, such as homebox A10 (HOXA10), heparin binding epidermal growth factor, and leukemia inhibitory factor, are also useful markers (Achache and Revel, 2006). Sperm quality is commonly evaluated by a semen routine (sperm quantity, motility, and morphology), seminal plasma biochemistry (seminal plasma fructose and α-glucosidase), and DNA fragmentation (Esteves and Chan, 2015).…”

Section: Outcome Measures In Clinical Trials For Ea and Teasmentioning

confidence: 99%

Use of electroacupuncture and transcutaneous electrical acupoint stimulation in reproductive medicine: a group consensus

Sun

et al. 2017

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:With the rapid development of assisted reproductive technology, various reproductive disorders have been effectively addressed. Acupuncture-like therapies, including electroacupuncture (EA) and transcutaneous electrical acupoint stimulation (TEAS), become more popular world-wide. Increasing evidence has demonstrated that EA and TEAS are effective in treating gynecological disorders, especially infertility. This present paper describes how to select acupoints for the treatment of infertility from the view of theories of traditional Chinese medicine and how to determine critical parameters of electric pulses of EA/TEAS based on results from animal and clinical studies. It summarizes the principles of clinical application of EA/TEAS in treating various kinds of reproductive disorders, such as polycystic ovary syndrome (PCOS), pain induced by oocyte retrieval, diminished ovarian reserve, embryo transfer, and oligospermia/ asthenospermia. The possible underlying mechanisms mediating the therapeutic effects of EA/TEAS in reproductive medicine are also examined.

show abstract

A systematic review of recent clinical practice guidelines and best practice statements for the evaluation of the infertile male

Cited by 58 publications

References 34 publications

Glutathione s-transferase as a marker of oxidative stress in human ejaculated spermatozoa from patients with pathospermia

Glutathione s-transferase as a marker of oxidative stress in human ejaculated spermatozoa from patients with pathospermia

Female subfertility

Use of electroacupuncture and transcutaneous electrical acupoint stimulation in reproductive medicine: a group consensus

Contact Info

Product

Resources

About