Relationship between pseudoexfoliation syndrome and erectile dysfunction: a possible cause of endothelial dysfunction for development of erectile dysfunction

Abstract

Objectives:Pseudoexfoliation syndrome (PES) is a common age-related fibrillopathy related to accumulation of pseudoexfoliation material (PEM) in certain places in the body, especially blood vessels. Erectile dysfunction (ED) is another condition related to vascular pathology and in this study it is aimed to identify the relationship between ED and PES.Materials and Methods:Data of 92 patients were investigated. There were 34 patients in the PES group and 58 patients in the control group. Presence of diabetes, hypertension, smoking history, BMI, and serum levels of lipids and testosterone were recorded. The groups were compared for ED rates and severity. Also logistic regression analysis was performed to identify independent risk factors for development of ED.Results:Mean age of the population was 67.3. No significant difference was observed between the two groups regarding the presece of DM, HT, smoking, BMI and laboratory measurements. ED rate was significantly higher in the PES group (70.6% vs 48.3%, p=0.002). Also, severe ED rate was higher in the PES group (p=0.002). PES was detected as an independent risk factors for the development of ED.Conclusion:ED is a possible consequence of PES. ED rate and severity is found to be higher in the PES group and PES is detected as an independent risk factor for development of ED. Patients with PES should be informed about development of ED and further prospective trials with objective measurements of penile blood flow should be conducted to verify the erectile status and penile blood fow in PES patients.

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

“…[7172] PEX is considered a systemic microfibrillinopathy closely linked to mutations in the lysyl oxidase-like 1 (LOXL1) gene,[51] with pseudoexfoliative material being found throughout visceral organs in affected individuals. [737475] Conjunctival biopsies of patients with unilateral PEX demonstrated microscopic disease in the unaffected fellow eye. [6] Our review of the literature has shown that clinically unaffected fellow eyes do not have significant differences in ECD compared to their paired eyes with PEX, with both showing similarly decreased ECD when compared to a group of age-matched controls.…”

A case–cohort study of exfoliation risk factors and literature review

“…Literature review of positive risk factors for XFS in general [Tables 5 - 7 ][ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 ] and XFS in young subjects [ Table 8 ][ 82 83 84 85 86 87 88 89 90 91 …”

“…In the Lebanese cohort under investigation, XFS was associated with advanced age, glaucoma, habitual ocular rubbing, and longer time for cataract surgery. While advanced age [ Table 6 ],[ 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 ] glaucoma [ Table 5 ],[ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 ] and longer surgery duration[ 100 ] are well established risk factors for XFS [ Table 5 ],[ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 <...>…”

Can subfoveal choroidal thickness replace subjective tests in patients using tadalafil to treat erectile dysfunction?

“…Recent studies concerning ED and the eye have reported interesting findings. An independent relationship has been observed between ED and pseudoexfoliation syndrome (PXS) characterised by accumulation of fibrillary material, generally in the anterior part of the eye (Gokce & Gokce, 2015). Those authors reported a higher presence of ED and higher severity in the PXS‐positive group compared with the control group.…”