Can subfoveal choroidal thickness replace subjective tests in patients using tadalafil to treat erectile dysfunction?

Aslan, Fatih; Topçuoğlu, Murat; Öktem, Çağlar; Akkoç, Ali; Uçar, Murat

doi:10.1111/and.13580

Cited by 4 publications

(2 citation statements)

References 23 publications

(26 reference statements)

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“…The choroidal thickening was attributed to the expansion of the stroma rather than vascular dilatation [ 23 ]. Recently Aslan et al observed an increase in small-choroidal-vessel-layer (choriocapillaris plus Sattler’s layer) and total choroidal thickness after 3 months of daily oral 5 mg tadalafil in patients with or without erectile dysfunction [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Retinal and Optic Disc Vascular Changes in Patients Using Long-Term Tadalafil: A Prospective Non-Randomized Matched-Pair Study

et al. 2021

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Retinal, choroidal and optic disc vascularity has never been evaluated in patients taking PDE5is long-term. The aim of our study was to evaluate the neurostructural and vascular changes after long-term use of tadalafil, using spectral domain (SD)-optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). In the present clinical trial, 27 patients who have been taking tadalafil 20 mg on alternate days (OAD) for at least 6 months (Group A) were enrolled. The matched group consisted of 27 healthy men (Group B). Both groups of patients underwent SD-OCT to study ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) and choroidal thickness and OCTA for the evaluation of superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC) and radial peripapillary capillary (RPC). A reduction in SCP, DCP and RPC vessel density was found in patients using tadalafil long-term. Retinal and optic disc toxicity may be detected using modifications of capillary vessel density. Further studies are needed to investigate the possibility of a causal association.

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Section: Discussionmentioning

confidence: 99%

Retinal and Optic Disc Vascular Changes in Patients Using Long-Term Tadalafil: A Prospective Non-Randomized Matched-Pair Study

et al. 2021

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“…This study has shown that this increase in CT may persist with chronic usage of the taladafil. 49 Phosphodiesterase-5 inhibitors are categorized as a possible risk factor for central serous chorioretinopathy, as current data are inconclusive as to whether phosphodiesterase-5 inhibitors cause central serous chorioretinopathy. 91 3.6 | Psychiatric and addictive substances…”

Section: Phosphodiesterase-5 Inhibitorsmentioning

confidence: 99%

The effect of systemic and topical ophthalmic medications on choroidal thickness: A review

Yeung

Park

et al. 2022

Brit J Clinical Pharma

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The choroid plays an important role in various ocular pathologies and retinal blood supply. There is a knowledge gap on how the choroid is affected by systemic and topical medications. Systemic medications that affect microvasculature elsewhere in the body can also affect the microvasculature of the choroid. This review summarizes current knowledge on associations between systemic and topical medications and changes in choroidal thickness (CT). This review included 71 studies on mydriatics/cycloplegics, intraocular pressure (IOP)‐lowering therapies, antihypertensives, adrenergic antagonists, statins, corticosteroids, hydroxychloroquine, isotretinoin, hormonal contraceptives, phosphodiesterase inhibitors, antipsychotics, antineoplastic agents, ethanol, caffeine and nicotine. IOP‐lowering therapies, atropine eye drops, and systemic administration of β blockers and ethanol are associated with a significant increase in CT. Cyclopentolate and phenylephrine are associated with a CT reduction. Systemic medications that decrease CT include caffeine and nicotine. Tropicamide, angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers, statins, corticosteroids, hydroxychloroquine and hormonal contraceptives have mixed findings. CT increase associated with IOP‐lowering therapies is possibly achieved by enhancing aqueous humour flow to the choroid thus elevating choroidal blood flow and thickness. CT changes appear to be independent from systemic blood pressure changes, suggesting that a significant association with an antihypertensive could be due to an idiosyncratic drug property. Statins and candesartan decrease macrophage accumulation and intercellular adhesion molecule 1 expression in the choroid. The choroid and its response to various disease processes and systemic medication can be further investigated to improve patient care, particularly in patients with choroid and retina pathologies.

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Changes in Posterior Ocular Structures in Individuals Using Phosphodiesterase 5 Inhibitor

Icoz,

Kocamanoglu

2024

Current Eye Research

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Can subfoveal choroidal thickness replace subjective tests in patients using tadalafil to treat erectile dysfunction?

Cited by 4 publications

References 23 publications

Retinal and Optic Disc Vascular Changes in Patients Using Long-Term Tadalafil: A Prospective Non-Randomized Matched-Pair Study

Retinal and Optic Disc Vascular Changes in Patients Using Long-Term Tadalafil: A Prospective Non-Randomized Matched-Pair Study

The effect of systemic and topical ophthalmic medications on choroidal thickness: A review

Changes in Posterior Ocular Structures in Individuals Using Phosphodiesterase 5 Inhibitor

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