Human papillomavirus infection is not related with prostatitis-related symptoms: results from a case-control study

Bartoletti, Riccardo; Cai, Tommaso; Meliani, E.; Mondaini, Nicola; Meacci, Francesca; Addonisio, Patrizia; Albanese, Sara; Nesi, Gabriella; Mazzoli, Sandra

doi:10.1590/s1677-5538.ibju.2014.02.16

Cited by 16 publications

(21 citation statements)

References 27 publications

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“…25 In this study, the distribution of HPV genotypes in co-infected men confirmed the increased circulation of the genotypes LR-HPV42 and HR-HPV51 especially among young people, as recently emerged from other Italian surveys. 10,26 Recently, Perino et al 27 reported that couples who underwent assisted reproductive technology cycles experienced an increased risk of pregnancy loss when HPV DNA testing was positive in the male partner, compared with non-infected patients. The HR-HPV51 and HR-HPV52 were the genotypes most frequently identified in the male partner of infertile couples.…”

Section: Discussionmentioning

confidence: 99%

Chlamydia trachomatis and HPV co‐infections in HIV negative men from a multi‐ethnic area of Northern Italy at high prevalence of cervical malignancies

Comar

Monasta

Seraceni

et al. 2017

Journal of Medical Virology

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Chlamydia trachomatis and HPV coinfections in the male population are often a disregarded issue. We performed a study to evaluate the prevalence of such infections in heterosexual HIV negative men from a Northern Italy multi-ethnic area at high prevalence for cervical malignancies. Urethral swabs (US) or first-voided urine were evaluated retrospectively from 1317 patients attending Sexually Transmitted Infections (STI) clinic and from 3388 outpatients attending private clinics. Informations about participants' demographic characteristics and attributes of C. trachomatis, including chronic infection, and HPV genotypes testing, were collected. Exact Fisher test, bivariate, and multivariate logistic regressions were carried out. The prevalence of C. trachomatis was 1.7% in the outpatients and 16.9% in the STI group (P < 0.0001) in which the highest frequency was observed in men of age ≤25 years. Among patients with C. trachomatis, asymptomatic HPV co-infection was detected in 33% of men from the STI clinic and in 2% of the outpatients. Out of all coinfections, 56% were due to single HPV, with a prevalence of 73% in young STI men. The distribution of HPV genotypes confirmed the increased circulation of LR-HPV42, HR-HPV51, HR-HPV52 and prHR-HPV82, and the decreasing of HR-HPV16. African nationalities and leucorrhea were significantly associated risk factors, while the regular condom use offered an effective protection. This study highlights the high prevalence of C. trachomatis and HPV asymptomatic co-infection in young HIV negative men attending the STI clinic, representing a reservoir of new HPV genotypes with potential oncogenic risk.

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Section: Discussionmentioning

confidence: 99%

Chlamydia trachomatis and HPV co‐infections in HIV negative men from a multi‐ethnic area of Northern Italy at high prevalence of cervical malignancies

Comar

Monasta

Seraceni

et al. 2017

Journal of Medical Virology

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“…It has been proposed that exposure to environmental factors such as infectious agents and dietary carcinogens, and hormonal imbalances lead to injury of the prostate gland and to the development of chronic inflammation and regenerative ‘risk factor’ lesions, referred to as proliferative inflammatory atrophy (PIA) 65 .Two meta-analyses with the statistically significant evidence of the association between prostatitis and prostate cancer 66 67 also suggest that inflammation resulting from infections may be one mechanism for prostate cancer carcinogenesis. Although a case-control study has showed that HPV infections are not related with prostatitis-related symptoms when urethral swab was used for HPV detection 68 , another study has showed that HPV was identified in the prostatic secretions from patients with type III prostatitis and might be associated with the degree of intraprostatic inflammation 69 . Whether HPV infections associated with the risk of prostate cancer is mediated by chronic prostatic inflammation which leads to initiation and progression of prostate cancer, needs further functional research.…”

Section: Discussionmentioning

confidence: 99%

Worldwide Prevalence of Human Papillomavirus and Relative Risk of Prostate Cancer: A Meta-analysis

Yang

Xie

Feng

et al. 2015

Sci Rep

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Despite the increasing number of studies conducted recently to evaluate the association between HPV infections and the risk of prostate cancer, the results remain inconclusive. Furthermore, the prevalence and distribution of overall and individual HPV types worldwide in prostate cancer has not been reported until now. Therefore, we estimated the prevalence of HPV in prostate cancer by pooling data of 46 studies with 4919 prostate cancer cases, taking into account the heterogeneity of major related parameters, including study region, specimen type, HPV DNA source, detection method, publication calendar period and Gleason score. Moreover, we tested the association of HPV infections with prostate cancer risks by a meta-analysis of 26 tissue-based case-control studies. We found that the prevalence of HPV infection was 18.93% (95% CI = 17.84–20.05%) in prostate cancer cases, and most of which were high-risk HPV types (17.73%, 95% CI = 16.52–18.99%). The prevalence varied by region, PCR primers used, publication calendar period and Gleason score. Our study also showed a significantly increased risk of prostate cancer with the positivity of overall HPV detected in prostate tissues (OR = 1.79, 95% CI = 1.29–2.49) and revealed the geographic variation of association strength (P < 0.001). In conclusion, HPV infections may contribute to the risk of prostate cancer.

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“…Based on meta-analyses of 21 studies by Zhang et al, there is a correlation and enhanced risk between prostatitis leading to benign prostate hyperplasia and finally prostate cancer [87]. Multiple pathogenic organisms including high risk HPVs have been identified in prostatic secretions and semen of patients with prostatitis [88][89][90][91]. The biology underlying inflammation and cancer is complex particularly if infectious agents such as HPVs are involved.…”

Section: Human Papillomavirus Prostatitis Benign Prostate Hyperplasmentioning

confidence: 99%

Evidence for a causal role by human papillomaviruses in prostate cancer – a systematic review

Lawson

Glenn

2020

Infect Agents Cancer

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It is hypothesised that high risk for cancer human papillomaviruses (HPVs) have a causal role in prostate cancer. In 26 case control studies, high risk HPVs have been identified in benign and prostate cancers. High risk HPVs were identified in 325 (22.6%) of 1284 prostate cancers and in 113 (8.6%) of 1313 normal or benign prostate controls (p = 0.001). High risk HPVs of the same type have been identified in both normal and benign prostate tissues prior to the development of HPV positive prostate cancer. High risk HPVs can be associated with inflammatory prostatitis leading to benign prostate hyperplasia and later prostate cancer. Normal human prostate epithelial cells can be immortalised by experimental exposure to HPVs. HPVs are probably sexually transmitted. The role of HPVs in prostate cancer is complex and differs from HPVs associated cervical cancer. HPV infections may initiate prostate oncogenesis directly and influence oncogenesis indirectly via APOBEC enzymes. HPVs may collaborate with other pathogens in prostate oncogenesis. Although HPVs are only one of many pathogens that have been identified in prostate cancer, they are the only infectious pathogen which can be prevented by vaccination. A causal role for HPVs in prostate cancer is highly likely.

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Human papillomavirus infection is not related with prostatitis-related symptoms: results from a case-control study

Abstract: ARTICLE INFO

Cited by 16 publications

References 27 publications

Chlamydia trachomatis and HPV co‐infections in HIV negative men from a multi‐ethnic area of Northern Italy at high prevalence of cervical malignancies

Chlamydia trachomatis and HPV co‐infections in HIV negative men from a multi‐ethnic area of Northern Italy at high prevalence of cervical malignancies

Worldwide Prevalence of Human Papillomavirus and Relative Risk of Prostate Cancer: A Meta-analysis

Evidence for a causal role by human papillomaviruses in prostate cancer – a systematic review

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