Abstract:Bone offers has a favorable environment that stimulates prostate cancer tumor growth in a vicious cycle fed by growth factors released by own osteoblasts (1). Radium223 (Ra-223) is a radioisotope, it delivers energy radiation to prostate cancer bone metastasis leading to DNA damage. Ra-223 is the only commercially released alpha-emitter that targets osteoblastic bone metastases used for treatment of metastatic castration resistant prostate cancer (mCRPC). The ALSYMPCA2 Phase III trial (2) compared Ra-223 effic… Show more
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