Adenomyoepithelioma with malignant transformation diagnosed by immunohistochemical analysis: case report

Abstract

Adenomyoepitheliomas (AMEs) are rare breast lesions, which are characterized by the proliferation of epithelial and myoepithelial cells. They are circumscribed lesions, which can be clinically and mammographically detected. However, when they are indistinctly limited, differential diagnosis with malignant lesions becomes difficult. In this paper, we report a case of adenomyoepithelioma with malignant transformation of the myoepithelial component, a rare histological type that arises from the malignant transformation of epithelial, myoepithelial, or both elements. Its course and prognosis are uncertain. Mastectomy with sentinel lymph node biopsy followed by radiotherapy are the most effective treatment approaches.

Adenomyoepithelioma of the breast with late pulmonary metastases – case report and review of the literature

“…Similar microscopic appearance with primary breast tumour, identical immunohistochemical profile and two foci located within the same lung support metastatic rather that primary origin of pulmonary lesions. Several authors conclude that breast AMEs performing as tumours over 2 cm should be treated as potentially malignant [ 3 , 5 , 7 , 8 , 17 ]. Two primary breast lesions in our case were over 2 cm each.…”

“…For the first time this tumour was reported in the breast by Hamperl in 1970 [ 6 , 7 ]. The biological behavior of tumours developing in mammary glands may range from benign to malignant transformation of either epithelial or myoepithelial component separately or both [ 2 , 7 , 8 ]. The age of patients with breast adenomyoepithelioma ranges from 26 to 82 years, with an average of around 60 years [ 9 ].…”

“…The age of patients with breast adenomyoepithelioma ranges from 26 to 82 years, with an average of around 60 years [ 9 ]. These lesions develop usually as single foci with possible infiltration of surrounding breast tissue [ 8 ]. Foci of calcification may be seen on ultrasound examination.…”