N-acetil-β-D-glicosaminidase como biomarcador precoce de disfunção renal para a exposição ocupacional ao chumbo inorgânico

Gonçales, Leandro Nishikawa; Paoliello, Mônica Maria Bastos; Janeiro, Vanderly; Machinski, Miguel

doi:10.1590/s1676-24442008000400003

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Regarding neurotoxicity, it can be expressed as decreased reasoning and neuropathy, and the increase in circulating aminolevulinic acid may be responsible for some of the behavioral disorders observed in patients with lead toxicity (16). Other symptoms that are commonly observed are nephropathy and hypertension (17,18). Also, hematological disorders that lead to anemia might happen, as consequence of lead toxicity on red cells and erythropoiesis in the bone marrow (4,19).…”

Section: Resultsmentioning

confidence: 99%

Lead evaluation in children's lipsticks through atomic absorption spectrometry

Fagundes¹,

Rossato‐Grando²,

Souza³

et al. 2021

Drug Anal. Res.

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Lead is a metal with recognized toxicity and it is known that it may be a contaminant in lipsticks. In Brazil, the Health Regulatory Agency (ANVISA) determines that the maximum limit allowed for the presence of lead in lipsticks is 20 ppm. Children are more vulnerable to lead toxicity. The objective of this study was to evaluate the presence of lead in infant lipsticks. Nineteen samples from four different brands sold in Brazil were evaluated. After sample extraction, analyses were performed by graphite furnace atomic absorption spectrometry. Lead was not detected in any of the tested lipsticks. Considering the presence of lead in adult makeup, the present study reinforces the need to use products intended for children considering kids are more vulnerable to lead toxic effects.

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Section: Resultsmentioning

confidence: 99%

Lead evaluation in children's lipsticks through atomic absorption spectrometry

Fagundes¹,

Rossato‐Grando²,

Souza³

et al. 2021

Drug Anal. Res.

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Autochthonous probiotic Lactobacillus sp. in the diet of bullfrog tadpoles Lithobates catesbeianus improves weight gain, feed conversion and gut microbiota

Pereira

Jerônimo²,

Marchiori

et al. 2016

Aquacult Nutr

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Dietary supplementation with probiotics in animal production is an alternative to antibiotics. In frog culture, studies involving native strains of probiotic bacteria and their effects on the performance and intestinal histology of farmed animals are scarce. Therefore, this study aimed to evaluate a diet supplemented with Lactobacillus sp. in tadpoles of Lithobates catesbeianus. This randomized test was performed with two dietary treatments: non‐supplemented control diet and diet supplemented with Lactobacillus sp., with nine replications. The growth performance of Lactobacillus sp., including its bacterial enzymatic activity and stability in feed, as well as colonization and histology of the intestinal tract, was evaluated after 42 days of experimentation. Animals fed with a supplemented diet showed higher weight gain and concentration of lactic acid bacteria in the gut and lower feed conversion. No significant difference was observed in survival, total heterotrophic bacterial count or histological change in the gut between the two treatments. The Lactobacillus sp. strain was able to colonize the intestinal tract and feed and remain at a high concentration of 107 and 106 CFU g−1, respectively. It produced several enzymes, which might have contributed to the greater weight gain and lower feed conversion in the supplemented animals, thus demonstrating its probiotic potential for use as a dietary supplement in bullfrog tadpoles.

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Renal biomarkers of male and female Wistar rats (Rattus norvegicus) undergoing renal ischemia and reperfusion

Bazzano¹,

Restel²,

Porfírio³

et al. 2015

Acta Cir. Bras.

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PURPOSE:To investigate biomarkers of acute renal injury in Wistar rats, subjected to left renal ischemia for 10 minutes, and then compare reperfusion at 24 hours, and at 5, 7, 14 and 21 days after the procedure. METHODS:Eight female and male rats between 60 and 81 days old were used in the Central Animal Facility of the UFMS. Assessed biomarkers included urine protein, urea, creatinine, glucose, sodium, potassium, urine alkaline phosphatase and gamma-glutamyl transferase activities, and protein-to-creatinine ratio; and in serum: urea, creatinine, sodium and potassium, fractional excretion of sodium, potassium, urine flow and creatinine clearance. RESULTS:Greater variance was observed in the parameters at 24 hours and at five days (p<0.05) after reperfusion. On the 21 st day, these parameters approximated those obtained for the control group. CONCLUSIONS:Renal ischemia for 10 minutes was sufficient to raise urine levels of protein, glucose, fractional excretion of potassium, urea, creatinine clearance, urine activity of gamma-glutamyltransferase and alkaline phosphatase enzymes in the first 24 hours, up to five days after reperfusion, which may indicate risk of acute kidney injury, according to the RIFLE classification.

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N-acetil-β-D-glicosaminidase como biomarcador precoce de disfunção renal para a exposição ocupacional ao chumbo inorgânico

Cited by 3 publications

References 16 publications

Lead evaluation in children's lipsticks through atomic absorption spectrometry

Lead evaluation in children's lipsticks through atomic absorption spectrometry

Autochthonous probiotic Lactobacillus sp. in the diet of bullfrog tadpoles Lithobates catesbeianus improves weight gain, feed conversion and gut microbiota

Renal biomarkers of male and female Wistar rats (Rattus norvegicus) undergoing renal ischemia and reperfusion

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