Anti-helmínticos na toxocaríase experimental: efeito na recuperação de larvas de Toxocara canis e na resposta humoral

Lescano, Susana Angélica Zevallos; Chieffi, Pedro Paulo; Neto, Vicente Amato; Ikai, Denise Katia; Ribeiro, Maria Fernanda Muzetti

doi:10.1590/s1676-24442005000100006

Cited by 15 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LESCANO et al 61 studied the effects of treatment with ivermectin, mebendazole or thiabendazole on larval recovery of T. canis and on immune response in experimental infected BALB/c mice. At the end of the experiments, a significant decrease in larvae recovered from treated mice was observed compared to infected and untreated mice with no parasitological cure; confirming that the three drugs used in this experiment had similar efficacies.…”

Section: Research In Brazilmentioning

confidence: 99%

Human toxocariasis: contribution by Brazilian researchers

Chieffi

Santos

Queiroz

et al. 2009

Rev. Inst. Med. trop. S. Paulo

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Research In Brazilmentioning

confidence: 99%

Human toxocariasis: contribution by Brazilian researchers

Chieffi

Santos

Queiroz

et al. 2009

Rev. Inst. Med. trop. S. Paulo

Self Cite

View full text Add to dashboard Cite

show abstract

“…Lescano et al (2005) tested this drug in rats artificially infected with T. canis, observing a significant reduction in parasite load, but no parasitological cure. However, other authors have reported a dose of 0.2 mg/kg to be effective against this helminth (BOWMAN et al, 2010).…”

Section: Fecrt (%) G1 Fecrt (%) G2mentioning

confidence: 99%

Efficacy of pyrantel pamoate and ivermectin for the treatment of canine nematodes

et al. 2015

View full text Add to dashboard Cite

This study evaluated the efficacy of pyrantel pamoate and ivermectin on gastrointestinal nematodes in dogs. Fecal egg counts per gram (EPG) were measured by the fecal egg count reduction test (FECRT) in order to evaluate the anthelmintic efficiency and fecal float exams were also performed to assess the concordance between coproparasitological techniques. A total of 45 naturally infected dogs in the city of Bandeirantes, Paraná State, were selected and divided into three groups: Group 1, 15 animals that received pyrantel pamoate (145 mg) in a single dose; Group 2, 15 animals that received ivermectin (3 mg); and Group 3, 15 animals that comprised an untreated control group. Fecal testing was performed two and 10 days after treatment. Toxocara was the most prevalent genus, followed by Ancylostoma and Trichuris. Ancylostoma had low resistance to ivermectin and pyrantel pamoate treatment, while Toxocara were resistant to both treatments. Statistical correlation testing to compare coproparasitogical techniques revealed moderate concordance, substantial and almost perfect concordance for detection of Ancylostoma, Trichuris, and Toxocara, respectively. The results of this study suggest that the gender Ancylostoma had low resistance and Toxocara is resistant to both drugs and because of their high prevalence in young animals means that others anthelmintic drugs may be recommended to combat infections. Additionally, the Gordon and Whitlock modified and Willis-Mollay techniques are effective for detection particularly of Toxocara in dogs. Key words: Ancylostomiasis, dogs, parasitic resistance, toxocariasis ResumoObjetivou-se neste estudo avaliar a eficácia do pamoato pirantel e da ivermectina sobre nematódeos gastrointestinais de cães. Para tanto foram realizados a contagem de ovos nas fezes (OPG) para avaliação da eficiência anti-helmíntica através do Teste de Redução da Contagem de Ovos nas Fezes (RCOF) e exame de flutuação Willis-Mollay para verificação de concordância entre as técnicas coproparasitológicas. Selecionou-se 45 cães na cidade de Bandeirantes, Paraná, naturalmente infectados, os quais foram divididos em três grupos experimentais: Grupo 1, 15 animais que receberam pamoato de pirantel 145 mg; Grupo 2, 15 animais que receberam ivermectina 3 mg e Grupo 3, 15 animais do grupo controle, não tratados. Coletas de fezes foram realizadas dois e dez dias depois para realização dos exames coproparasitológicos. Observou-se que o gênero de maior prevalência foi Toxocara, seguido de Ancylostoma e Trichuris. Ancylostoma apresentou baixa resistência ao tratamento

show abstract

“…The diagnosis of toxocariasis is performed using an enzyme-linked immunosorbent assay (ELISA) specific for excretion-secretion antigens, 12 and the classic treatment is antihelminthic drugs. 13 Toxocariasis has always been present but has had varying prevalence rates. A study conducted by Campos Júnior and Elefant 14 showed a significant difference between the prevalence of seropositivity for T. canis among children from poor neighborhoods in Brasilia (21.8%) and children living in the wealthiest sectors of the city (3%).…”

mentioning

confidence: 99%

A Systematic Review of Toxocariasis: A Neglected But High-Prevalence Disease in Brazil

Fialho¹,

Corrêa²

2016

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Toxocariasis is an anthropozoonosis that occurs in all parts of the world. In particular, this disease can often be found in developing countries and in regions, where basic sanitation conditions are poor. However, industrialized countries have reported seroprevalence rates as high as 14.2% in humans. The definitive hosts of the disease are dogs and cats, whereas humans are a paratenic host. To determine the burden of toxocariasis in Brazil, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to conduct a systematic review of the literature. Using keywords and applying the established criteria, we identified 160 publications and selected 22 articles for further analysis. The seroprevalence of toxocariasis in various regions of the country ranged from 4.2% to 65.4%. The highest prevalence was found in the northeast region, although the majority of the studies identified were from the southeast region. The findings suggest the importance of raising awareness among health professionals and public authorities about the fact that toxocariasis is a health problem.

show abstract

Anti-helmínticos na toxocaríase experimental: efeito na recuperação de larvas de Toxocara canis e na resposta humoral

Cited by 15 publications

References 0 publications

Human toxocariasis: contribution by Brazilian researchers

Human toxocariasis: contribution by Brazilian researchers

Efficacy of pyrantel pamoate and ivermectin for the treatment of canine nematodes

A Systematic Review of Toxocariasis: A Neglected But High-Prevalence Disease in Brazil

Contact Info

Product

Resources

About