Haptoglobin phenotypes in Brazilian patients with leukemia

Campregher, Paulo Vidal; Lorand‐Metze, Irene; Grotto, Helena Zerlotti Wolf; Sonati, María de Fátima

doi:10.1590/s1676-24442004000500005

Cited by 7 publications

(4 citation statements)

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“…In contrast to previous studies (Nevo and Tatarsky, 1986;Mitchell et al, 1988), Campregher et al (2004) found no association between leukemia (ALL, CLL, AML and CML) and the higher frequencies of the Hp1 allele in these patients in southeastern Brazil, although the p-value for patients with CLL tended towards significance. In contrast, ahaptoglobinemia was more frequent among these patients, in agreement with the findings of Fröhlander (1984).…”

Section: Association Studies In Brazilian Populationscontrasting

confidence: 99%

Polymorphism of human haptoglobin and its clinical importance

2008

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Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.

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Section: Association Studies In Brazilian Populationscontrasting

confidence: 99%

Polymorphism of human haptoglobin and its clinical importance

2008

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“…Because the expression of BCR/ABL stimulates ROS production, which may contribute to increased DNA damage in CML cells (Sattler et al, 2000;Nowicki et al, 2004), the Hp polymorphism has been investigated in leukemias, and the Hp1-1 phenotype has been associated with increased risk (Nevo and Tatarsky, 1986;Mitchell et al, 1988;Campregher et al, 2004). Despite the small sample size and large confidence interval, results indicated increased CML risk for Hp1F-1S individuals of black skin color and decreased risk for the same group carrying the Hp1S-2 genotype.…”

Section: Discussionmentioning

confidence: 99%

“…Polymorphic variants of several genes, diet, environmental exposure to carcinogens and individual immune system's characteristics are potential factors that increase predisposition to leukemia (Bowen et al, 2003). Association studies have been performed to identify genetic variants associated with CML susceptibility, and among them are methylenetetrahydrofolate reductase (MTHFR) (Hur et al, 2006;Moon et al, 2007;Barbosa et al, 2008), glutathione S-transferases (GSTs) (Hishida et al, 2005;Souza et al, 2008), and haptoglobin (Hp) gene polymorphisms (Nevo and Tatarsky, 1986;Campregher et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Association between methylene tetrahydrofolate reductase and glutathione S-transferase M1 gene polymorphisms and chronic myeloid leukemia in a Brazilian population

Lordelo¹,

Miranda-Vilela²,

Akimoto³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Chronic myeloid leukemia is a hematopoietic stem cell disorder that causes uncontrolled proliferation of white blood cells. Although the clinical and biological aspects are well documented, little is known about individual susceptibility to this disease. We conducted a case-control study analyzing the prevalence of the polymorphisms MTHFR C677T, MTHFR A1298C, del{GSTM1}, del{GSTT1}, and haptoglobin in 105 patients with chronic myeloid leukemia (CML) and 273 healthy controls, using PCR-based methods. A significant association with risk of developing CML was found for MTHFR 1298AA (odds ratio (OR) = 1.794; 95% confidence interval (CI) = 1.14-2.83) and GSTM1 non-null (OR = 1.649; 95%CI = 1.05-2.6) genotypes, while MTHFR 1298AC (OR = 0.630; 95%CI = 0.40-G.S. Lordelo et al. 1014©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (2): 1013-1026 (2012) 0.99) and GSTM1 null (OR = 0.606; 95%CI = 0.21-0.77) genotypes significantly decreased this risk. There appeared to be selection for heterozygosity at the MTHFR 1298 locus. The considerable range of variation in this and other human populations may be a consequence of distinctive processes of natural selection and adaptation to variable environmental conditions. The Brazilian population is very mixed and heterogeneous; we found these two loci to be associated with CML in this population.

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“…).There are five references for blood malignancies such as acute and chronic lymphoid leukemia and acute myeloid leukemia from three different ethnic groups Sweden, Israel and Brazil (Caucasians and Afro-descendants) and only one sample of Ashkenazy Jews(Germinis A et al 1983, Nevo S and Tatarsky I 1986, Mitchell RJ et al 1988, Fröhlander N and Stendahl U 1988, Campregher PV et al 2004.Cutaneous malignancies and in particular squamous cell carcinoma (SCC)/Bowen´s disease are more frequent in kidney transplanted patients, that are more prone to disease when are Haptoglobin and Cancer: Various Tumours.The Role of Haptoglobin and Its Genetic Polymorphism in Cancer: A Review http://dx.doi.org/10.5772/56695 carriers of Hp 1.1 phenotypes particularly after ten years of the transplantation (Speeckaert R et al 2012). The same happens in the development of Kaposi´s sarcoma in HIV positive patients, even after adjustment for age, gender and AIDS status (Speeckaert R et al 2011).…”

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confidence: 99%