The Role of Haptoglobin and Its Genetic Polymorphism in Cancer: A Review

Bicho, Maria Clara; Silva, Alda Pereira da; Medeiros, Rui; ManuelBicho,

doi:10.5772/56695

Cited by 1 publication

(3 citation statements)

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“…Particularly the unprocessed pre-HP, called zonulin, was identified in this kind of brain cancer [56]. It was also demonstrated in studies in vitro on GBM that HP increases cell migration [52]. This evidence, joined to the highest presence of this protein in the A− zone rather than the A+ zone in ND-GBM (Figure 18), could correlate this protein to the GBM tumor invasiveness.…”

Section: Haptoglobin (Hp)mentioning

confidence: 79%

“…HP is a glycoprotein of the plasma that is involved in anti-inflammatory processes, in prophylaxis of oxidative damage and in tissue protection. Its primarily role is to bind hemoglobin (Hb) to increase its affinity with the CD163 receptor on hepatocytes, monocytes and macrophages [52]. In this way, HP removes free Hb by the plasma, preventing the production of radical species of oxygen catalyzed by heme.…”

Section: Haptoglobin (Hp)mentioning

confidence: 99%

“…In this way, HP removes free Hb by the plasma, preventing the production of radical species of oxygen catalyzed by heme. Other HP functions are inhibition of prostaglandin synthesis, support of the angiogenesis and modulation of the immune system [52]. This last function is very important in tumor disease because it was demonstrated, in a study on lung cancer, that HP can protect the tumor cells from attack by the immune system [53].…”

Section: Haptoglobin (Hp)mentioning

confidence: 99%

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Investigating Glioblastoma Multiforme Sub-Proteomes: A Computational Study of CUSA Fluid Proteomic Data

Moresi

Rossetti

Vincenzoni

et al. 2022

IJMS

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Based on our previous proteomic study on Cavitating Ultrasound Aspirator (CUSA) fluid pools of Newly Diagnosed (ND) and Recurrent (R) glioblastomas (GBMs) of tumor core and periphery, as defined by 5-aminolevulinc acid (5-ALA) metabolite fluorescence, this work aims to apply a bioinformatic approach to investigate specifically into three sub-proteomes, i.e., Not Detected in Brain (NB), Cancer Related (CR) and Extracellular Vesicles (EVs) proteins following selected database classification. The study of these yet unexplored specific datasets aims to understand the high infiltration capability and relapse rate that characterizes this aggressive brain cancer. Out of the 587 proteins highly confidently identified in GBM CUSA pools, 53 proteins were classified as NB. Their gene ontology (GO) analysis showed the over-representation of blood coagulation and plasminogen activating cascade pathways, possibly compatible with Blood Brain Barrier damage in tumor disease and surgery bleeding. However, the NB group also included non-blood proteins and, specifically, histones correlated with oncogenesis. Concerning CR proteins, 159 proteins were found in the characterized GBM proteome. Their GO analysis highlighted the over-representation of many pathways, primarily glycolysis. Interestingly, while CR proteins were identified in ND-GBM exclusively in the tumor zones (fluorescence positive core and periphery zones) as predictable, conversely, in R-GBM they were unexpectedly characterized prevalently in the healthy zone (fluorescence negative tumor periphery). Relative to EVs protein classification, 60 proteins were found. EVs are over-released in tumor disease and are important in the transport of biological macromolecules. Furthermore, the presence of EVs in numerous body fluids makes them a possible low-invasive source of brain tumor biomarkers to be investigated. These results give new hints on the molecular features of GBM in trying to understand its aggressive behavior and open to more in-depth investigations to disclose potential disease biomarkers.

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Section: Haptoglobin (Hp)mentioning

confidence: 79%

Section: Haptoglobin (Hp)mentioning

confidence: 99%