Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil

Loureiro, Monique Morgado; Morais, José Carlos; Milito, Cristiane; Portugal, Rodrigo de Souza; Pulcheri, Wolmar; Spector, Nelson

doi:10.1590/s1676-24442004000100010

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Pediatric series from Argentina exhibited a profile compatible with early cHL (i.e., younger ages, EBV positivity of ~50% and HL-MC as the predominant subtype) [ 20 , 25 , 26 , 27 ], while adult HL displayed a 31% of EBV-association, with similar frequencies of both NS and MC subtypes [ 22 ]. On the other hand, in the Southeast of Brazil, EBV positivity was 40–50%, HL-NS was the predominant subtype, and there was a smooth peak between adolescents and young adults [ 38 , 41 , 42 , 43 , 44 , 45 , 47 , 52 , 58 , 60 , 66 , 67 , 68 , 69 , 70 , 73 ], which may suggest a transition state in the epidemiology of the disease presentation between the ones observed in developing and developed areas. Indeed, one study in the most affluent Brazilian State (Sao Paulo) reviewed 817 cases of cHL over 54 years (1954–2008), describing that EBV-positive cases showed a decrease from 87% to 46% during the time of the study, with a remarkable decrease in young adults (85% to 32%) [ 32 ].…”

Section: Epstein–barr Virusmentioning

confidence: 99%

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Chabay

Lens

Hassan

et al. 2020

Cancers

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The Epstein–Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations.

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Section: Epstein–barr Virusmentioning

confidence: 99%

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Chabay

Lens

Hassan

et al. 2020

Cancers

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“…In a study from Rio de Janeiro, EBV was detected in 55% of cases, its presence being significantly correlated (88%) with the MC subtype (16) .…”

Section: Discussionmentioning

confidence: 96%

Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization

Pinto¹,

Ferreira²,

Pitombeira

et al. 2006

J. Bras. Patol. Med. Lab.

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key words unitermos resumoThe prevalence of Epstein-Barr virus (EBV) in patients with classical Hodgkin's lymphoma (CHL) is geographically variable. In the present study the prevalence of EBV in CHL was assessed in adult patients from Ceará, Brazil. Thirty-seven cases were immunohistochemically evaluated for EBV using latent membrane protein (LMP1) antibody and for EBV latency-associated RNA (EBER1) using in situ hybridization (ISH). Sex and age did not differ among patients as to the frequency of CHL. Nodular sclerosis was the predominant histological subtype. LMP1 was found in Reed-Sternberg cells in 67.5% of the cases whereas ISH detected EBER1 in 75.6%. Regarding histological subtypes EBV infection rates were not found statistically different in nodular sclerosis (NS) and mixed cellularity (MC) subtypes (p = 0.66). Lab • v. 42 • n. 3 • p. 201-205 • junho 2006

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Pediatric Hodgkin Lymphoma in 2 South American Series: A Distinctive Epidemiologic Pattern and Lack of Association of Epstein-Barr Virus With Clinical Outcome

Chabay¹,

Barros²,

Hassan³

et al. 2008

Journal of Pediatric Hematology/Oncology

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Hodgkin lymphoma (HL) shows a bimodal distribution with a first peak in developing countries during childhood. The causative role and prognostic significance of Epstein-Barr virus (EBV) association in patients with HL is controversial. Our aim was to perform a comparative study of EBV association in 2 Latin American pediatric HL series, and to correlate it with patient's survival. Epstein-Barr encoded RNAs in situ hybridization and latent membrane protein 1 immunohistochemistry were performed on formalin-fixed, paraffin-embedded HL biopsies from 176 pediatric patients from 2 public institutions from Argentina and Southeast Brazil. Mixed cellularity subtype was prevalent in Argentine HL (Arg HL) (52%) and nodular sclerosis subtype in Brazilian HL (BR HL) (83%). EBV expression was detected in 52% of cases, namely 54% Arg HL and 48% Br HL. EBV was significantly associated with mixed cellularity subtype in both populations. In Arg HL, EBV positivity was significantly higher in patients

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Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil

Cited by 4 publications

References 10 publications

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization

Pediatric Hodgkin Lymphoma in 2 South American Series: A Distinctive Epidemiologic Pattern and Lack of Association of Epstein-Barr Virus With Clinical Outcome

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Expression of Epstein-Barr virus in patients with Hodgkin's disease: report of 64 cases from Rio de Janeiro, Brazil

Cited by 4 publications

References 10 publications

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization

Pediatric Hodgkin Lymphoma in 2 South American Series: A Distinctive Epidemiologic Pattern and Lack of Association of Epstein-Barr Virus With Clinical Outcome

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Analysis of the association between Epstein-Barr virus and classic Hodgkins lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization