Simultaneous occurrence of follicular lymphoma and mixed-cellularity Hodgkin's lymphoma: lymph node and extranodal involvement

Grangeiro, Maria do Patrocínio Ferreira; Magalhães, S.M.M.; Ferreira, Francisco Valdeci; Filho, Francisco Dário Rocha

doi:10.1590/s1676-24442004000100009

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…A Organização Mundial da Saúde, classifica os linfomas em mais de 30 tipos, com o principal critério de classificação consistindo no tumor originado de células B (86%), Células T (12%) ou células natural killer (NK) (2%). Além disso, Grangeiro (2004) Barcelos (2009) Ainda segundo Barcelos et al (2009), para a classificação dos linfomas não Hodgkin, o sistema REAL/WHO considerou a morfologia das células linfoides, a presença de proteínas na superfície das células (imunofenotipagem) e as características genéticas. Além disso, os vários tipos de Linfoma não Hodgkin foram agrupados conforme o tipo de célula linfoide do tipo B ou T, e, de acordo com o prognóstico, em:…”

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Aspectos Clínicos E Histopatológicos Dos Linfomas Hodking E Não Hodking: Uma Revisão Sistemática / Clinical and Histopathological Aspects of Hodking and Non-Hodking Lymphomas: A Systematic Review

Oliveira

Cruz

Rockenbach

et al. 2021

BJD

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Os linfomas englobam um grupo heterogêneo de doenças geradas por linfócitos malignos, sendo sua maior prevalência no sexo masculino, com dois picos de morbidade: um entre os 20 e 30 anos e outro entre os 60 e 70 anos de idade. O presente trabalho objetiva explicitar o Linfoma de Hodgkin e Linfoma de Não-Hodgkin, sua incidência na sociedade atual e alertar acerca da importância do conhecimento sobre essa patologia. Para isso, foi feita uma revisão bibliográfica de cunho qualitativo-descritivo, utilizando as bases de dados PubMed, Scielo, LILACS e Google Acadêmico. Os Linfomas Hodgkin são divididos em dois tipos histológicos: linfoma de Hodgkin com predominância linfocítica nodular e linfoma de Hodgkin clássico (LHC), enquanto que os vários tipos de Linfoma não Hodgkin foram agrupados conforme o tipo de célula linfoide do tipo B ou T, e, de acordo com o prognóstico, em: indolentes, agressivos e muito agressivos. Deste modo, reconhecer bem os aspectos clínicos, a fim de somar para uma suspeita diagnóstica, com investigação e confirmação através dos meios histopatológicos, torna-se ferramenta indispensável ao manejo correto dos pacientes com Linfomas, sejam eles Hodgkin ou não Hodgkin.

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Section: Introductionunclassified

Aspectos Clínicos E Histopatológicos Dos Linfomas Hodking E Não Hodking: Uma Revisão Sistemática / Clinical and Histopathological Aspects of Hodking and Non-Hodking Lymphomas: A Systematic Review

Oliveira

Cruz

Rockenbach

et al. 2021

BJD

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“…The classification of lymphomas is based on the tumoral cell origin, histologic characteristics, immunophenotype, microenvironment, and molecular data 1. Most lymphomas originate from an unique cellular origin, however, in a rare instance, 2 distinct lymphomas can be associated: (i) simultaneously in the same location, defining a composite lymphoma2,3; (ii) simultaneously at 2 different locations, defining a simultaneous/synchronous lymphoma,4 often classified as composite lymphoma5–8; and (iii) consecutively, defining a sequential lymphoma 7,9. The cellular and molecular mechanisms involved in composite/sequential lymphomas needs to be better understood.…”

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Plasticity of Mature B Cells Between Follicular and Classic Hodgkin Lymphomas

Trécourt¹,

Mauduit

Szablewski

et al. 2021

American Journal of Surgical Pathology

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Follicular lymphoma and classic Hodgkin lymphoma can be associated in composite and/or sequential lymphomas. Common IGH and BCL2 rearrangements have already been identified between both contingents of these entities, but mutation profiles have not yet been investigated. The main objective of this study was to analyze the transdifferentiation process that may occur between Hodgkin and follicular contingents in sequential and composite lymphomas to better characterize these entities. From 2004 to 2020, a retrospective multicentric study was performed, including 9 composite and 13 sequential lymphomas. Clinical data were retrospectively collected. Fluorescent in situ hybridization of BCL2 and BCL6 rearrangements, polymerase chain reaction of IGH and IGK rearrangements, next-generation sequencing of IGK rearrangement, and targeted next-generation sequencing (TNGS) on a panel of genes frequently mutated in lymphomas were performed on each contingent of composite and sequential lymphomas. For TNGS, each contingent was isolated by laser capture microdissection. Clinical presentation and evolution were more aggressive in sequential than composite lymphomas. By fluorescent in situ hybridization, common rearrangements of BCL6 and BCL2 were identified between both contingents. Similarly, a common clonal relationship was established by evaluating IGH and IGK rearrangement by polymerase chain reaction or next-generation sequencing. By TNGS, the same pathogenic variants were identified in both contingents in the following genes: CREBBP, KMT2D, BCL2, EP300, SF3B1, SOCS1, ARID1A, and BCOR. Specific pathogenic variants for each contingent were also identified: XPO1 for Hodgkin lymphoma contingent and FOXO1, TNFRSF14 for follicular lymphoma contingent. This study reinforces the hypothesis of a transdifferentiation process between Hodgkin and follicular contingent of sequential/composite lymphomas.

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Simultaneous occurrence of follicular lymphoma and mixed-cellularity Hodgkin's lymphoma: lymph node and extranodal involvement

Cited by 2 publications

References 11 publications

Aspectos Clínicos E Histopatológicos Dos Linfomas Hodking E Não Hodking: Uma Revisão Sistemática / Clinical and Histopathological Aspects of Hodking and Non-Hodking Lymphomas: A Systematic Review

Aspectos Clínicos E Histopatológicos Dos Linfomas Hodking E Não Hodking: Uma Revisão Sistemática / Clinical and Histopathological Aspects of Hodking and Non-Hodking Lymphomas: A Systematic Review

Plasticity of Mature B Cells Between Follicular and Classic Hodgkin Lymphomas

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