Avaliação da expressão da proteína bcl-2 no carcinoma de mama: estudo em punção aspirativa por agulha fina; correlação com grau histológico em espécimes cirúrgicos correspondentes

Derossi, Daniela Rudgeri; Ito, K.; Filho, José D'Oliveira Couto; Bacchi, Carlos E.

doi:10.1590/s1676-24442003000300010

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…Some prostate tumors and neuroblastomas with positive BCL-2 immunoreactivity have highly aggressive biological behavior. This can be explained by the resistance to hormone and/ or cytotoxic therapy, due to the persistence of BCL-2 expression and its capacity to inhibit apoptosis [39]. With regard to endometrial carcinoma, however, several studies show that increased BCL-2 expression is associated with some favorable prognostic factors-endometrioid-like, well-differentiated lesions in initial stages [9,[16][17][18][19].…”

Section: Time (Months) Cumulative Survival Negativementioning

confidence: 99%

p53 and BCL-2 as Prognostic Markers in Endometrial Carcinoma

Appel

Edelweiss

Fleck

et al. 2008

Pathol. Oncol. Res.

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The objective of this study was to verify the frequency of p53 and BCL-2 immunohistochemical expression in patients with endometrial carcinoma and to correlate it with histological factors (histological type, tumor grade, depth of myometrial invasion, lymph node involvement and surgical staging) and survival. Forty-eight patients with endometrial carcinoma who were submitted to primary surgical treatment were assessed. p53 and BCL-2 immunohistochemical expression was determined using paraffin blocks containing the tumor area. p53 and BCL-2 expression was detected in 39.6% and 58.3% of the tumors, respectively. No significant difference was found regarding the frequency of p53 expression when analyzing histological type (33.3% in endometrioid tumors, 58.3% in non-endometrioid tumors; p = 0.176), depth of myometrial invasion (p = 0.632) and surgical staging (I-11.1%, II-66.7%, III-57.1%; p = 0.061). p53 expression was significantly more frequent in undifferentiated tumors (p = 0.007) and in those showing lymph node involvement (p = 0.030). Univariate analysis showed a positive association with death (RR, 3.358; CI, 1.386-8.134; p = 0.005) and short-term survival. The present study did not reveal any correlation between BCL-2 expression and histopathologic markers or survival. In conclusion, this study showed that p53 expression is directly correlated with undifferentiated tumors, lymph-node involvement and risk of death. On the other hand, BCL-2 expression was not correlated with any known histological factors.

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Section: Time (Months) Cumulative Survival Negativementioning

confidence: 99%

p53 and BCL-2 as Prognostic Markers in Endometrial Carcinoma

Appel

Edelweiss

Fleck

et al. 2008

Pathol. Oncol. Res.

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“…O gene bcl-2 é considerado anti-apoptótico, responsável por regular a ativação de caspases, e por isso é considerado favorável quando sua expressão é encontrada em carcinomas, como por exemplo o de mama (Derossi, Ito, Couto, José & Bacchi, 2003;Facchini & Penn,1998;Kelly, Cochran, Stiles & Leder, 1983;Leve & Morgado-Díaz,2012;Marcu, Bossone & Patel, 1992;Scarff. & Torloni,1968.…”

Section: Resultsunclassified

Estudos In silico sobre as atividades anticancerígenas do Eugenol presente no Cravo Da Índia (Syzygium aromaticum)

Oliveira

Arruda

2021

RSD

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Objetivo: Investigar as propriedades anticancerígenas do eugenol usando métodos In silico. Metodologia: é um artigo original utilizando a metodologia In silico atraves dos softwares PASS (Prediction of activity spectra for substances) online e GUSAR disponíveis de forma gratuita e livre. Resultados: Os resultados do sistema operacional online PASS demonstraram diversas atividades biológicas positiva, tais quais efeito antimutagênico, estimulante de caspase, tratamento pré neoplásico e agonista de apoptose tendo uma probabilidade de atividade (PA) bem superior a 0,700. Tais achados reforçam aos descritos na literatura que evidenciam um potencial antineoplásico devido o componente ter efeitos antioxidante, e estar vinculado a expressão de genes envolvidos na apoptose e inflamação. Tal como efeitos na regulação negativa de Bcl-2, COX-2 e IL-1ß, e ações na regulação positiva de P53, Bax e expressão ativa de Caspase-3, caspase-9 além de induzir a via da apoptose mitocondrial. Já pelo software GUSAR, foi observado a toxicidade, demonstrando que na categoria 4, estão as vias de administração intravenosa, oral, e subcutânea, indicando que é pouco tóxico. Já na categoria 5 enquadra-se a via intraperitoneal é relativamente atóxico. Tal achado ainda é obscuro e possui poucos artigos científicos para o embasamento. Conclusão: O Eugenol possui efeitos favoráveis para o tratamento e prevenção de diversos canceres e células mutagênicas, porém ainda há pouco conhecimento sobre a toxicidade deste componente. Assim, necessita de um maior aprofundamento sobre a temática.

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“…5 This maintains the balance between cell proliferation and programmed cell death, which is the mechanism by which cells with damaged DNA are removed without causing any harm. 18 Moreover, MED12 has been reported to be one of the most frequently mutated genes in FAs, located on chromosome Xq13.1. The high frequency of MED12 mutations in fibro-epithelial tumours suggests that it is a somatic gene leading to fibro-epithelial tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Complex fibroadenoma: bibliometric literature review and presentation of a clinical case

Cardoso¹,

Schröder²,

Zimermann³

et al. 2020

Mastology

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Fibroadenomas (FAs) are benign fibro-epithelial tumours of the breast characterized by being biphasic and having stromal and epithelial components. It is estimated that FAs affect more than 20 percent of the general population aged 16–40 years old. Complex FAs are a sub-type of fibroadenoma presenting one or more pathological characteristics, such as epithelial calcifications, apocrine metaplasias, sclerosing adenoma and cysts larger than 3 mm. According to studies elsewhere, women with complex FAs are 3.1 times more likely to develop breast cancer. The objective of the present study was to map the scientific production of articles on complex FA in the international literature. The ISI Web of Knowledge (Web of Science), one of the main scientific databases in the world, was searched with the following terms: (“complex” and “fibroadenoma”) or (“fibroadenoma” and “complex”). Only articles published between 1981 and 2019 were considered for a bibliometric review, in which 160 articles from 126 different periodicals were identified after using refinement filters. Moreover, a clinical case was also discussed based on the patient’s medical record and interview.

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Avaliação da expressão da proteína bcl-2 no carcinoma de mama: estudo em punção aspirativa por agulha fina; correlação com grau histológico em espécimes cirúrgicos correspondentes

Cited by 5 publications

References 29 publications

p53 and BCL-2 as Prognostic Markers in Endometrial Carcinoma

p53 and BCL-2 as Prognostic Markers in Endometrial Carcinoma

Estudos In silico sobre as atividades anticancerígenas do Eugenol presente no Cravo Da Índia (Syzygium aromaticum)

Complex fibroadenoma: bibliometric literature review and presentation of a clinical case

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