Estudo da produção de beta -lactamase e sensibilidade às drogas em linhagens de estafilococos coagulase-negativos isolados de recém-nascidos

Cunha, Maria de Lourdes Ribeiro de Souza da; Lopes, Carlos Alberto de Magalhães

doi:10.1590/s1676-24442002000400006

Cited by 12 publications

(16 citation statements)

References 15 publications

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“…studied. In contrast, Cunha and Lopes [59] found that 71.8% of CoNS isolated from newborns hospitalized in the neonatal unit of HC-FMB produced β-lactamase, all of them being nosocomial strains. According to Hovelius and Mardh [60], chromogenic cephalosporin (nitrocefin) does not detect β-lactamase production in S. saprophyticus .…”

Section: Discussionmentioning

confidence: 96%

Oxacillin Resistance and Antimicrobial Susceptibility Profile of Staphylococcussaprophyticus and Other Staphylococci Isolated from Patients with Urinary Tract Infection

Ferreira¹,

Bonesso²,

Mondelli

et al. 2012

Chemotherapy

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Background:Staphylococcus saprophyticus is the second most frequent community-acquired causative agent of urinary tract infection (UTI). The objective of this study was to evaluate the susceptibility profile and resistance detection in Staphylococcus species. isolated from patients with UTI. Materials and Methods: The isolates were investigated using the disk diffusion method, Vitek I system, E-test®, and detection of the mecA gene. Results: Most isolates (76.2%) were resistant to oxacillin by the disk diffusion method, followed by those resistant to penicillin (72.2%). The oxacillin disk diffusion method, E-test, and Vitek I method showed higher sensitivity (94.4%) and lower specificity (28.9, 26.5, and 24.0%, respectively) than the cefoxitin disk diffusion test (sensitivity: 83.5%, specificity: 85.5%) for the detection of oxacillin resistance. Conclusions: The large number of oxacillin-resistant isolates indicates that the breakpoint value recommended by the Clinical and Laboratory Standards Institute may overestimate oxacillin resistance in S. saprophyticus. Thus, changes in these guidelines are necessary for the correct detection of this resistance.

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Section: Discussionmentioning

confidence: 96%

Oxacillin Resistance and Antimicrobial Susceptibility Profile of Staphylococcussaprophyticus and Other Staphylococci Isolated from Patients with Urinary Tract Infection

Ferreira¹,

Bonesso²,

Mondelli

et al. 2012

Chemotherapy

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“…In the present study the bacteria were isolated in hospital environments with a high number of immunosuppressed patients; therefore, all the Staphylococcus that we found must be considered pathogenic. Coagulase-negative Staphylococci are among the main causes of hospital bacteremia, in special affecting patients from ICUs (Cunha et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Microbiota associated with tramp ants in a Brazilian University Hospital

Teixeira¹,

Pelli²,

Santos³

et al. 2009

Neotrop. entomol.

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-Our aim was to study the fauna of ants in the Hospital Universitário of the Universidade Federal do Triângulo Mineiro, municipality of Uberaba, Minas Gerais State, Brazil, as well as to identify the microorganisms the ants carry and their patterns of resistance to antibiotics. Sterile tubes (traps) containing honey were used to attract the ants. Traps were exposed for 3h, and those which attracted ants were considered the test group, while the ones that did not attract the insects constituted the control group. Only the ant species Tapinoma melanocephalum (Fabricius) was sampled. Sixty microorganisms were isolated from the sampled ants, including seven Gram-positive bacilli, 14 Gram-negative bacilli, 22 Grampositive cocci and 17 filamentous fungi. Pseudomonas, Staphylococcus and Group D Streptococcus were the microorganisms with the highest resistance to the tested antibiotics. The ants should be considered an important vector of infections as they carry several pathogenic microorganisms, spreading them on the surface of sterile materials, equipments and uncontaminated food. It is impossible to define the exact role of ants in nosocomial infections at this moment; however, this issue must be better studied and special attention must be given by the commissions of Nosocomial Infection Control.

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“…On the basis of in vitro observations, the CLSI (11) recommends oxacillin-resistant Staphylococcus to be reported as resistant to all beta-lactams, including cephalosporins and carbapenems. In Brazil, Cunha and Lopes (13), analyzing CNS strains isolated from newborns, observed that 71.8% of the isolates were producers of beta-lactamase and about 50% of these strains were resistant to oxacillin.…”

Section: Epidemiological Aspectsmentioning

confidence: 99%

Methicillin Resistance in Staphylococcus aureus and Coagulase‐Negative Staphylococci: Epidemiological and Molecular Aspects

Martins

Cunha

2007

Microbiology and Immunology

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Infections caused by the genus Staphylococcus are of great importance for human health. Staphylococcus species are divided into coagulase‐positive staphylococci, represented by S. aureus, a pathogen that can cause infections of the skin and other organs in immunocompetent patients, and coagulase‐negative staphylococci (CNS) which comprise different species normally involved in infectious processes in immunocompromised patients or patients using catheters. Oxacillin has been one of the main drugs used for the treatment of staphylococcal infections; however, a large number of S. aureus and CNS isolates of nosocomial origin are resistant to this drug. Methicillin resistance is encoded by the mecA gene which is inserted in the SCCmec cassette. This cassette is a mobile genetic element consisting of five different types and several subtypes. Oxacillin‐resistant strains are detected by phenotypic and genotypic methods. Epidemiologically, methicillin‐resistant S. aureus strains can be divided into five large pandemic clones, called Brazilian, Hungarian, Iberian, New York/Japan and Pediatric. The objective of the present review was to discuss aspects of resistance, epidemiology, genetics and detection of oxacillin resistance in Staphylococcus spp., since these microorganisms are increasingly more frequent in Brazil.

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Estudo da produção de beta -lactamase e sensibilidade às drogas em linhagens de estafilococos coagulase-negativos isolados de recém-nascidos

Cited by 12 publications

References 15 publications

Oxacillin Resistance and Antimicrobial Susceptibility Profile of Staphylococcussaprophyticus and Other Staphylococci Isolated from Patients with Urinary Tract Infection

Oxacillin Resistance and Antimicrobial Susceptibility Profile of Staphylococcussaprophyticus and Other Staphylococci Isolated from Patients with Urinary Tract Infection

Microbiota associated with tramp ants in a Brazilian University Hospital

Methicillin Resistance in Staphylococcus aureus and Coagulase‐Negative Staphylococci: Epidemiological and Molecular Aspects

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