Quality of life and treatment adherence in hypertensive patients: systematic review with meta-analysis

Abstract

OBJECTIVE To verify the effects of antihypertensive treatment (pharmacological and non-pharmacological) on the health-related quality of life of individuals with hypertension.METHODS We conducted a systematic review with meta-analysis using the following databases: IBECS, LILACS, SciELO, Medline, Cochrane, Science Direct, Scopus and the Brazilian Capes Theses and Dissertations Database. The statistical analysis was performed using Review Manager, version 5.2. The average difference was used for the summarization of meta-analytic effect by the fixed-effect model. Twenty studies were included.RESULTS The summarization of the effect showed an average increase of 2.45 points (95%CI 1.02–3.87; p < 0.0008) in the quality of life of individuals adhering to non-pharmacological treatment for arterial hypertension. Adherence to pharmacological treatment indicated an average increase of 9.24 points (95%CI 8.16–10.33; p < 0.00001) in the quality of life of individuals with arterial hypertension.CONCLUSIONS Non-pharmacological treatment improves the overall quality of life and physical domain of people with arterial hypertension. Adherence to pharmacological treatment has a positive impact on the mental and physical domains of patients, as it did on the overall quality of life score.

Alexithymia: A facet of uncontrolled hypertension

“…The second subsection focused on a classification that considered pharmacological treatment. This aspect has a significant impact on the quality of life (Lauziére et al, 2013;Schmidt, Bramlage, Limberg, & Kreutz, 2008;Souza, Borges, & Moreira, 2016) and it is usually associated with higher severity of hypertension (Whelton et al, 2017).…”

Hypertension: Drug Adherence and Social Factors

“…Therapeutic adherence is higher in patients with better education and better knowledge about their disease, and also with greater economic income [31][32][33]. Adherents present better quality of life, both in their physical and their mental status [34]. Health literacy and education should be a priority in these patients and in all people [29].…”

Treatment Adherence and Quality of Life of Patients With Stable Ischemic Heart Disease in Treatment With Nicorandil: Interrelation and Interaction (According to the Results of the Observational Study Nikea)

“…и Реброва А.П., хо-рошая приверженность к лекарственной терапии у пациентов с хронической сердечной недостаточ-ностью является независимым значимым предикто-ром повышения КЖ у таких больных [относительный риск (ОР) 4,10; 95% доверительный интервал (ДИ) 1,15-14,16; p=0,01] [18]. По данным систематиче-ского обзора с мета-анализом исследований КЖ и приверженности к лечению у пациентов с артериаль-ной гипертонией было продемонстрировано, что хо-рошая приверженность к немедикаментозному лечению повышает средний показатель качества жизни почти в 2,5 раза: ОР=2,45 (95% ДИ 1,02-3,87; p<0,0008), а приверженность к лекарственной тера-пии -более, чем в 9 раз: ОР=9,24 (95% ДИ 8,16-10,33; p<0,00001) [19].…”