Efeito do treinamento físico como modulador positivo nas alterações no eixo neuroimunoendócrino em indivíduos com insuficiência cardíaca crônica: possível atuação do fator de necrose tumoral-alfa

Rosa, Luís Fernando Bicudo Pereira Costa; Júnior, Miguel Luiz Batista

doi:10.1590/s1517-86922005000400007

Cited by 8 publications

(6 citation statements)

References 49 publications

(105 reference statements)

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“…treadmill exercise) contributes to maintaining the number of myenteric neurons Martinez Gagliardo et al 2008). Chronic, moderate physical exercise stimulates the immune response (Nakamura et al 2010;Soares et al 2010) and serves as a positive modulator when considering neuroimmunoendocrine changes in patients with chronic heart failure (Rosa & J unior 2005). Chronic, moderate physical exercise stimulates the immune response (Nakamura et al 2010;Soares et al 2010) and serves as a positive modulator when considering neuroimmunoendocrine changes in patients with chronic heart failure (Rosa & J unior 2005).…”

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confidence: 99%

“…Such exercise has also been shown to be a resistance factor in the development of infections caused by protozoa in animals (Soares et al 2010;Occhi et al 2012). Chronic, moderate physical exercise stimulates the immune response (Nakamura et al 2010;Soares et al 2010) and serves as a positive modulator when considering neuroimmunoendocrine changes in patients with chronic heart failure (Rosa & J unior 2005). Research conducted in animals has revealed positive effects of chronic, moderate physical exercise (i.e.…”

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confidence: 99%

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Moderate physical exercise reduces parasitaemia and protects colonic myenteric neurons in mice infected with Trypanosoma cruzi

Moreira

Santos

Toledo

et al. 2013

Int J Experimental Path

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This study evaluated the influence of moderate physical exercise on the myenteric neurons in the colonic intestinal wall of mice that had been infected with Trypanosoma cruzi. Parasitology and immunological aspects of the mice were considered. Forty-day-old male Swiss mice were divided into four groups: Trained Infected (TI), Sedentary Infected (SI), Trained Control (TC), and Sedentary Control (SC). The TC and TI were subjected to a moderate physical exercise program on a treadmill for 8 weeks. Three days after finishing exercise, the TI and SI groups were inoculated with 1,300 blood trypomastigotes of the Y strain-T. cruzi. After 75 days of infection results were obtained. Kruskal-Wallis or Analyze of variance (Tukey post hoc test) at 5% level of significance was performed. Moderate physical exercise reduced both the parasite peak (day 8 of infection) and total parasitemia compared with the sedentary groups (P < 0.05). This activity also contributed to neuronal survival (P < 0.05). Exercise caused neuronal hypertrophy (P < 0.05) and an increase in the total thickness of the intestinal wall (P < 0.05). The TI group exhibited an increase in the number of intraepithelial lymphocytes (P > 0.05). In trained animals, the number of goblet cells was reduced compared with sedentary animals (P < 0.05). Physical exercise prevented the formation of inflammatory foci in the TI group (P < 0.05) and increased the synthesis of TNF-α (P < 0.05) and TGF-β (P > 0.05). The present results demonstrated the benefits of moderate physical exercise, and reaffirmed the possibility of that it may contribute to improving clinical treatment in Chagas' disease patients.

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confidence: 99%

mentioning

confidence: 99%

Moderate physical exercise reduces parasitaemia and protects colonic myenteric neurons in mice infected with Trypanosoma cruzi

Moreira

Santos

Toledo

et al. 2013

Int J Experimental Path

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“…A reduction in plasma concentration of TNF-α, IL-6 and their receptors in soluble form have also been demonstrated in individuals with HF undergoing an aerobic training program 55 , suggesting a reduction in the chronic inflammatory condition, mediated by a regulation in peripheral inflammatory response 56,57 . However, despite the marked restorative and/or anti-inflammatory effect of exercise in these conditions, little is known about the possible mechanisms by which aerobic training can modulate this process 57 .…”

Section: Effect Of Aerobic Training On Pro-inflammatory Cytokines In Hfmentioning

confidence: 97%

“…However, despite the marked restorative and/or anti-inflammatory effect of exercise in these conditions, little is known about the possible mechanisms by which aerobic training can modulate this process 57 .…”

Section: Effect Of Aerobic Training On Pro-inflammatory Cytokines In Hfmentioning

confidence: 99%

Efeito anti-inflamatório do treinamento físico na insuficiência cardíaca: papel do TNF-α e da IL-10

Júnior¹,

Lópes²,

Seelaender³

et al. 2009

Arq. Bras. Cardiol.

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Over the past 50 years, the understanding of the deteriorative changes involved in the progression of heart failure (HF), initially described as resulting from changes in salt and fluid retention, or changes in hemodynamic parameters, have changed significantly. Recently, several studies conducted in HF patients showed altered plasma (or serum) levels of pro-inflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukins 1, 6, and 18, and cardiotropin-1, among other inflammatory markers. These changes were independent of HF etiology, suggesting a common pathogenic pathway. In response to these new findings, interventions to prevent and/or reduce these inflammatory changes have been proposed.The aerobic training-induced cardiovascular benefits of physical exercises performed at intensities ranging from mild to moderate have been previously reported. Moreover, it has been shown that moderate aerobic physical training seems to be able to modulate, in the presence of an abnormal chronic inflammatory condition, the overexpression of pro-inflammatory cytokines, soluble adhesion molecules, chemoattractant factors and oxidative stress. Altogether, these data indicate a possible anti-inflammatory effect induced by physical training.Therefore, this review aims to assess the role of physical training as an alternative non-pharmacological adjuvant to be administered in some pathological conditions in which TNF-α chronic changes are predominant, as in HF. The "antiinflammatory effect" induced by physical training seems to be primarily mediated by IL-10.

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“…O treinamento físico moderado exerce um efeito positivo nas variáveis cardiocirculatórias, atua como um importante imunomodulador positivo, revertendo, mesmo que de maneira parcial, as alterações inflamatórias decorrentes do quadro de insuficiência cardíaca, reforçando seu papel de intervenção não farmacológica reduzindo, assim, os seus sintomas (9,10).…”

Section: Materiais E Métodosunclassified

Exercício físico aeróbico em mulheres com doença de Chagas

Mendes

Lopes

Nogueira³

et al. 2011

Fisioter. mov.

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INTRODUÇÃO: A forma cardíaca da doença de Chagas causa modificações orgânicas e funcionais, sendo o exercício físico aeróbio uma alternativa de proposta terapêutica. OBJETIVO: avaliar o exercício físico aeróbio em mulheres com doença de Chagas crônica. MATERIAIS E MÉTODOS: Quatorze mulheres com doença de Chagas na faixa etária entre 40 e 60 anos, classe I da New York Heart Association (NYHA) foram divididas em dois grupos. Sete no G1 que realizaram exercício físico, com duas sessões diárias semanais por seis semanas e sete no G2 sem tal intervenção. O efeito do exercício físico foi avaliado por 27 variáveis fisioterapêuticas e ergoespirométricas no tempo zero (T0) e após seis semanas (T6). RESULTADO: No T6 em relação ao T0 a avaliação fisioterapêutica mostrou diferenças significativas na pressão arterial sistólica, no pico do fluxo expiratório, nas pressões inspiratória e expiratória máximas e na frequência cardíaca. Na ergoespirometria houve aumento significativo no DP máximo, no MET máximo, no estágio do protocolo de Bruce, no VO2 máximo, na duração do teste e na distância percorrida para as participantes de G1 e apenas na duração do teste para G2. Para G1 foi ainda observada em T6 uma diminuição significativa do duplo produto na intensidade moderada e alta na mesma carga de esforço. CONCLUSÃO: O treinamento aeróbio de curto período, de simples aplicação e com supervisão pode ser realizado com segurança, aumentando a tolerância ao exercício em pacientes com doença de Chagas crônica classe I da NYHA.

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Efeito do treinamento físico como modulador positivo nas alterações no eixo neuroimunoendócrino em indivíduos com insuficiência cardíaca crônica: possível atuação do fator de necrose tumoral-alfa

Cited by 8 publications

References 49 publications

Moderate physical exercise reduces parasitaemia and protects colonic myenteric neurons in mice infected with Trypanosoma cruzi

Moderate physical exercise reduces parasitaemia and protects colonic myenteric neurons in mice infected with Trypanosoma cruzi

Efeito anti-inflamatório do treinamento físico na insuficiência cardíaca: papel do TNF-α e da IL-10

Exercício físico aeróbico em mulheres com doença de Chagas

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