Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat

Xie, Yuanhong; Zhang, Hongxing; Liu, Hui; Xiong, Likuan; Gao, Xueying; Jia, Hui; Lian, Zhengxing; Tong, Nengsheng; Han, Tao

doi:10.1590/s1517-838246220131278

Cited by 28 publications

(28 citation statements)

References 44 publications

(60 reference statements)

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“…K. marxianus is capable to assimilate lactose through β-galactosidase that hydrolyses this sugar to glucose and galactose, thus using these sugars as carbon source (Lane and Morrissey, 2010). This probiotic yeast could decrease cholesterol level, exert antifungal, antibacterial, antiinflammatory activity producing pro-inflammatory cytokines, thus reducing local and systemic inflammations (Pacini and Ruggiero, 2017;Şanlidere Aloğlu et al, 2016;Xie et al, 2015). Moreover, Rahbar Saadat et al (2020) recently described the inhibitory role of the EPSs produced by K. marxianus on colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Microbiological characterization of Gioddu, an Italian fermented milk

Maoloni

Blaiotta

Ferrocino

et al. 2020

International Journal of Food Microbiology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Microbiological characterization of Gioddu, an Italian fermented milk

Maoloni

Blaiotta

Ferrocino

et al. 2020

International Journal of Food Microbiology

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“…In the present study, rats fed with HCD showed marked fatty changes in hepatocytes. Xie et al has observed similar fatty changes in hypercholesterolemia induced hepatic tissues of rats.…”

Section: Discussionmentioning

confidence: 64%

EGCG exerts its protective effect by mitigating the release of lysosomal enzymes in aged rat liver on exposure to high cholesterol diet

Ravindran

Jaganathan

Kalaiselvi

2020

Cell Biochemistry & Function

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The aim is to test the hypothesis whether the cholesterol loaded lysosomes are capable of mediating lysosomal membrane permeabilization (LMP) during aging and to study the efficacy of epigallocatechin-3-gallate (EGCG) in preserving the lysosomal membrane stability. Aged rats were fed with high cholesterol diet (HCD) and treated with EGCG orally. Serum and tissue lipid status, cholesterol levels in lysosomal fraction, activities of lysosomal enzymes in lysosomal, and cytosolic fractions were measured. Transmission electron microscopic studies (TEM), oil red "O" (ORO) staining, and immunohistochemical analysis of oxidized low density lipoprotein (OxLDL) were carried out. Significant increase in serum, tissue lipid profile, and lysosomal cholesterol levels were observed in aged HCD-fed rats with a concomitant decrease in high density lipoprotein (HDL) levels. We also observed a significant increase in lipid accumulation in hepatocytes of aged HCD-fed rats by TEM, ORO, and immunohistochemical staining. Upon treatment with EGCG to aged HCD-fed animals, we found augmented levels of HDL with a concomitant decrease in lysosomal cholesterol levels and other lipoproteins. TEM studies and immunohistochemistry of OxLDL also showed a marked reduction in lipid deposition of hepatocytes. Thus, EGCG has preserved the lysosomal membrane stability in HCD stressed aged rats.Significance of the study: The research article is focused mainly on the effect of EGCG and its capability on mitigating the release of lysosomal enzymes in aged animals fed with HCD. The study signifies the cellular function of the organelle lysosome following administration of aged rats with HCD, which would make the readers to understand the action of EGCG and the interrelationship of both cholesterol and activity of lysosomes when cholesterol is loaded.

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“…The results showed that levels of cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C) in serum and liver and atherogenic index were meaningfully reduced (p < 0.01), and the high-density lipoprotein cholesterol (HDL-C) levels and anti-atherogenic index were significantly improved (p < 0.01) in rats. Furthermore, treatment of K. marxianus also decreased the build-up of lipid droplets in the liver and exhibited normal hepatocytes, which suggested a protective effect of Tibetan mushrooms in hyperlipidemic rats [101]. Besides, polysaccharides extracted from mushroom Phellinus linteus could significantly reduce the serum triglyceride, the blood cholesterol and serum LDL levels, and could increase HDL levels of the hyperlipemia mice.…”

Section: Other Bioactivities Of Mushroomsmentioning

confidence: 80%

Bioactivities and Health Benefits of Mushrooms Mainly from China

et al. 2016

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Many mushrooms have been used as foods and medicines for a long time. Mushrooms contain polyphenols, polysaccharides, vitamins and minerals. Studies show that mushrooms possess various bioactivities, such as antioxidant, anti-inflammatory, anticancer, immunomodulatory, antimicrobial, hepatoprotective, and antidiabetic properties, therefore, mushrooms have attracted increasing attention in recent years, and could be developed into functional food or medicines for prevention and treatment of several chronic diseases, such as cancer, cardiovascular diseases, diabetes mellitus and neurodegenerative diseases. The present review summarizes the bioactivities and health benefits of mushrooms, and could be useful for full utilization of mushrooms.

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Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat

Cited by 28 publications

References 44 publications

Microbiological characterization of Gioddu, an Italian fermented milk

Microbiological characterization of Gioddu, an Italian fermented milk

EGCG exerts its protective effect by mitigating the release of lysosomal enzymes in aged rat liver on exposure to high cholesterol diet

Bioactivities and Health Benefits of Mushrooms Mainly from China

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