Clinical significance of the isolation of Candida species from hospitalized patients

Abstract

In this study, we isolated and phenotypically identified 108 yeast strains from various clinical specimens collected from 100 hospitalized patients at three tertiary hospitals in São Luís-Maranhão, Brazil, from July to December 2010. The isolates were analyzed for their susceptibility to four of the most widely used antifungal agents in the surveyed hospitals, amphotericin B, fluconazole, 5-flucytosine and voriconazole. The species identified were Candida albicans (41.4%), Candida tropicalis (30.1%), C. glabrata (7.4%), Candida parapsilosis (5.5%), Candida krusei (4.6%), Cryptococcus neoformans (4.6%), Trichosporon spp . (3.7%), Candida norvegensis (0.9%), Rhodotorula glutinis (0.9%) and Pichia farinosa (0.9%). A higher isolation rate was observed in the following clinical specimens: urine (54 isolates; 50%), respiratory tract samples (21 isolates; 19.4%) and blood (20 isolates; 18.6%). Candida albicans isolates were 100% sensitive to all antifungal agents tested, whereas Candida krusei and Crytococcus neoformans displayed intermediate resistance to 5-flucytosine, with Minimal Inhibitory Concentration (MIC) values of 8 mg/mL and 16 mg/mL, respectively. Both strains were also S-DD to fluconazole with an MIC of 16 mg/mL. C. tropicalis was resistant to 5-flucytosine with an MIC of 32 μg/mL. This study demonstrates the importance of identifying the yeast species involved in community and nosocomial infections.

Postoperative Hepatobiliary Surgeries' Fungal Infections Epidemiology: Prevalence and Risk Factors

“…The Singh et al, [6] study who found fungal infection rate was only 11 % out of the 130 liver transplanted patients [6] . In this study 45.2% of the patients were positive culture for fungal infection, nearly 98% of positive culture were of candida species only this was in agreement with Magalhães et al, [5] study which showed that 89.8% of all the isolates (97 isolates) belonged to the Candida genus. In this study age, antibiotic use, liver disease, central venous catheter, urinary catheter, and ICU hospitalization more than 48 hours were the independent predictors of fungal infection, however in the study of Wang et al, [7] the distribution of Candida species did not differ between elderly (above 60) and younger patients (below 60) which is against the result of the current study.…”

“…In the present study the incidence rate of fungal infection among patients undergone major hepatobiliary surgeries in national liver institute is (45.2%) which is consistent with study of Magalhães et al, [5] at three different hospitals were (39%), (29.6%) and C (31.4%) [5] . The Singh et al, [6] study who found fungal infection rate was only 11 % out of the 130 liver transplanted patients [6] .…”

Nosocomial Yeast Infections Among Cancer Patients in Egypt: Species Distribution and Antifungal Susceptibility Profile

“…Infrequent yeast species including R. glutinis and Trichosporon species were isolated in our study. They are emergent yeast pathogens capable of causing invasive infections increasingly isolated from immunocompromised patients (19). Although R. glutinis and T. asahii are infrequent causes of yeast infection, they should be put into consideration in respiratory tract infections among cancer patients.…”

Characterization of the interactions between human high-molecular-mass kininogen and cell wall proteins of pathogenic yeasts, Candida tropicalis

“…The frequency of invasive infections caused by particular Candida species varies in terms of geographical distribution and prevalence among different groups of patients. However, the predominance of C. tropicalis infections in the particular regions of the world -especially in South America and South Asia -and the fact that this species is considered to be the second, after C. albicans, most commonly isolated species from the bloodstream in many locations, suggest that special attention should be paid to C. tropicalis (Chai et al, 2010;Ma et al, 2013;Magalhães et al, 2015).…”