Background:The frequency of nosocomial yeast infections has increased dramatically in the recent years. They are considered an important cause of morbidity and mortality in immunocompromised cancer patients. The majority of yeast infections are caused by Candida species. However, species like Trichosporon and Rhodotorula should be considered as possible infectious agents as well.Objectives: This study aimed at determining the prevalence of yeast species, their distribution among patients and the antifungal susceptibility profile at Oncology Center, Mansoura, Egypt.Methods: From December 2016 till November 2017, cancer patients who developed infective episodes two days or more following hospital admission were included in the study. Clinical samples were collected according to the site of infection using standard sterile procedures. Blood samples were cultured using the BACT-ALERT system. Fungal identification and susceptibility testing were performed by Vitek 2 system. Results:Eighty-seven fungal strains were obtained from our patients. A higher isolation rate was observed in urine samples (47.1%) followed by oropharyngeal (24.1%) and blood (21.8%) samples. The majority of the yeast species were Candida albicans (40.2%), C. tropicalis (14.9%), C. parapsilosis (9.2%), C. famata (6.9%) and C. guilliermondii (6.9%). Out of the 87 samples, 8 (9.2%) were resistant to fluconazole, 7 (8.0%) were resistant to flucytosine, 5 (5.7%) were resistant to voriconazole and amphotericin B, and no sample was resistant to caspofungin or micafungin. Conclusions:Vitek 2 system offers a novel method for the early identification and susceptibility testing of different yeast species. It helps to minimize the risk for emergence of resistant species and reduce mortality rates, particularly in cancer patients.

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Tuberculosis (TB) is a potentially fatal contagious disease that can affect almost any part of the body but is mainly an infection of the lungs. It has been present in humans since antiquity. In the past, tuberculosis has been called consumption, because it seemed to consume people from within, with a bloody cough, fever, pallor, and long relentless wasting. In Egypt, TB constitutes the second most important public health problem after schistosomiasis. Although Egypt has relatively low levels of TB according to data from the World Health of Organization, 2005:66% of TB cases occur among the socially and economically productive age groups of 15 to 54 years. According to Ministry of Health and Population (MOHP), Egypt; tuberculosis control is carried out through 111 chest centers and 39 chest disease hospitals. Treatment failure accounts for 3%–5%of the treatment outcome of new smear positive cases and 13%–17% of retreated cases and this is due to non-compliance to treatment, defi cient health education to the patient, poor patient knowledge regarding the disease and diabetes mellitus as co-morbid. The incidence and prevalence of tuberculosis in Egypt has been declining due to increased efforts of the MOHP. Prevalence dropped from 88/100,000 population in 1990 to 24 in 2008, according to data from WHO. SAARC Journal of Tuberculosis, Lung Diseases & HIV/AIDS; 2013; X(1); 43-49 DOI: http://dx.doi.org/10.3126/saarctb.v10i1.8677