Extended-spectrum β-lactamase-producing enterobacteriaceae in community-acquired urinary tract infections in São Luís, Brazil

Abstract

The number of ESBL-producing Enterobacteriaceae in community-acquired urinary tract infections worldwide is probably underestimated because of the technical difficulties encountered with their detection. In this study, out of 5,672 urine samples analyzed, 916 were positive for uropathogens, 472 of them being enterobacteria of which 7.6% produced β-lactamases. Analysis of the isolated from 36 patients showed a high level of antibiotic resistance, with 52.7% and 80.5% of isolates expressing blaTEM and blaCTX-M, respectively.

Antibiotic Resistance Trends and The ESBL Prevalence of Escherichia coli and Klebsiella spp Urinary Isolates in In-and Outpatients in a Tertiary Care Hospital in Istanbul, 2004 - 2012

“…5 ies (21,29,31). A study conducted in Brazil reported a higher resistance rate of 35% for nitrofurantoin in ESBL-producing E. coli (19). Also a review article from Turkey showed similar susceptibility rates, just as in our study for E. coli (20), suggesting the use of nitrofurantoin for the first-line empirical oral treatment of community-acquired uncomplicated UTIs.…”

Determination of Antibiotic Resistance and Pulsed-Field Gel Electrophoresis Profiles for the Extended-Spectrum β-Lactamase Producing Escherichia coli

“…The rate of ESBL-producing E. coli strains in Canada was 5.5 out of 100,000 people, 71% of which was due to community-acquired infections (13). The rate of community-acquired ESBL-producing E. coli infections in Israel was reported 57.8% in 2004 (14), while these rates were 1.5% -7.6% in Brazil, 3.5% in Italy, and 4.5% in Saudi Arabia (15). The ESBL rate was 13.3% in the studied hospital, which seemed about 8% lower than that of reported by PHI-Turkey and relatively higher than that of the developed Western countries (16).…”

Extended-Spectrum Beta-Lactamase Production by Enterobacteriaceae Isolates From Urine Cultures of Outpatients: Results of a 7-Year Follow-Up

“…için ise %42.2'dir 6 . TK-İYE'nda Brezilya'dan %1.5-7.6, İtalya'dan %3.5 ve Suudi Arabistan'dan %4.5 GSBL-pozitif Enterobacteriaceae oranları bildirilmiştir 10 . Ben-Ami ve arkadaşları 1 , poliklinik hastalarından elde edilen Enterobacteriaceae izolatlarında GSBL pozitifl iğini %34.6 (E.coli'de %33.5, Klebsiella spp.…”

“…Son zamanlarda özellikle Klebsiella spp. başta olmak üzere Enterobacteriaceae ailesi üyelerinde karbapenemaz üretimi görülmeye başlamışsa da, hem bizim (imipenem direnci %0.3), hem de diğer çalışmaların sonuçlarına göre en etkili antibiyotikler hala karbapenemlerdir 3,4,10,12,13,17,19 . Çalışmamızda amikasin ikinci en etkili antibiyotik (direnç %3.5) iken, diğer aminoglikozidlere karşı oldukça yüksek direnç oranları kaydedilmiştir (gentamisin %42.2, tobramisin %56.8).…”

“…Türkiye'den yapılan meta-analizde benzer düzeyde aminoglikozid direnci rapor edilmektedir 14 . Bazı çalışma-larda amikasin etkinliğinin oldukça yüksek olduğu görülmektedir [10][11][12][13]17 . Ancak özellikle gentamisin direncinin, bölgesel olarak çok geniş aralıkta dağılım gösterdiği (%10.5-85.2) dikkati çekmektedir 1,19 .…”